Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical ....Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical science, imaging and sensing. Important applications include the early detection of debilitating diseases and the advancement of understanding of cellular biology. This research will raise Australia's profile as a world leader in science and technology, building on our emerging presence in the biophysical sciences.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0882864
Funder
Australian Research Council
Funding Amount
$260,000.00
Summary
High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System. The addition of the TIRF equipment will provide researchers with access to one of Australia's most technologically advanced light microscopy systems. This system will support research across a number of high profile areas, and promote strategic collaborations in cell and neurobiology. The high resolution fast acquisition TIRF system will significantly enhance r ....High Speed Fluorescence Imaging coupled with Total Internal Reflection Microscopy and Fluorescence Recovery After Photobleaching System. The addition of the TIRF equipment will provide researchers with access to one of Australia's most technologically advanced light microscopy systems. This system will support research across a number of high profile areas, and promote strategic collaborations in cell and neurobiology. The high resolution fast acquisition TIRF system will significantly enhance research capacity and research excellence. Its acquisition will allow Australia to play a major role in the global challenge to advance understanding of cellular and molecular events, contributing significantly to the National Research Priority Area of Frontier Technologies for Building and Transforming Australian Industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0560906
Funder
Australian Research Council
Funding Amount
$578,145.00
Summary
Queensland High Throughput Confocal Cell Imaging facility. Interpretation of the huge amount of molecular information available from the rapid advances in genomics and proteomics now requires new high throughput technologies to examine cellular function. This proposal is for a high throughput fluorescent confocal microscopic imaging facility that can be applied in the fields of drug discovery, cell biology and toxicology. This facility allows the study of cell function, cell structure, and prote ....Queensland High Throughput Confocal Cell Imaging facility. Interpretation of the huge amount of molecular information available from the rapid advances in genomics and proteomics now requires new high throughput technologies to examine cellular function. This proposal is for a high throughput fluorescent confocal microscopic imaging facility that can be applied in the fields of drug discovery, cell biology and toxicology. This facility allows the study of cell function, cell structure, and protein expression in multi-well format, providing analyses at a speed and scale not formerly possible. This confocal imaging facility will add to the other high throughput systems for analysis of cell physiology currently established at Griffith University.Read moreRead less