Brain Ageing - Studying Causes And Developing Interventions
Funder
National Health and Medical Research Council
Funding Amount
$481,156.00
Summary
This fellowship will assist in better understanding the complex reasons for serious conditions (dementia, stroke, falls, walking impairment) affecting brain health in ageing individuals, and in developing ways to reduce the risk or impact of these conditions in affected people.
Molecular Imaging To Advance Treatment Of Dementia
Funder
National Health and Medical Research Council
Funding Amount
$412,419.00
Summary
Molecular imaging using a scan technique called positron emission tomography, enables detection and measurement of specific pathological features of disease such as the amyloid plaques of Alzheimer’s disease. This project will develop this technology for other aspects of brain disorders including dementias, Parkinson’s disease, traumatic brain injury and schizophrenia and use it to assist development of therapies and improve clinical diagnosis nation wide.
Tackling Key Epidemiological And Basic Scientific Research Issues In Prion Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$401,109.00
Summary
Proposed Practitioner Fellowship research will simultaneously include epidemiological and basic scientific projects, emphasising human prion disease. Epidemiological research will involve large-scale studies to clarify genetic factors that influence susceptibility to developing prion disease, as well as clarify whether Alzheimer disease is transmissible, while basic scientific research will include determining the characteristics of the misfolded prion proteins causing neuronal disease.
Identifying The Relationships Between Pathophysiology, Heterogeneity And Clinical Wellbeing In Parkinson’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$452,051.00
Summary
This research will investigate the key predictors of dementia, poor quality of life, falls, carer burden, need for institutionalisation and health care utilisation in PD. The research will incorporate sophisticated brain scanning techniques as well as diverse and novel technologies that measure brain functioning. The outcomes of this research will inform clinical practice, health care reform and the development of targeted therapies.
Mild Traumatic Brain Injury And The Risk Of Long-term Neurodegenerative And Neurobehavioural Disease
Funder
National Health and Medical Research Council
Funding Amount
$585,269.00
Summary
Considerable media attention surrounds the potential for long-term problems in individuals with high exposure to head impacts such as seen in sporting, civilian and/or military contexts. This study examines the long-term effects of mild traumatic brain injury (mTBI) and helps close the current knowledge gap of the impact of this disorder on individuals. There are no long term trials to answer the critical question of whether mild TBI causes long term problems in the brain.
Molecular Profiling To Identify Therapeutic Targets For Blinding Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$467,961.00
Summary
Understanding the molecular mechanisms underlying blinding diseases will allow for the development of new therapies. As an ophthalmologist with sub-specialty training in genetic eye diseases, this fellowship will enhance the synergy between my current research and clinical practice. During this fellowship I will lead research to uncover further genetic associations for eye disease, as well as interrogate patient-specific cell lines to elucidate specific signatures of disease development.