Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions ....Integrated Nanoplatform for Multiomics Analysis of Cell-to-Cell Interaction. This project aims to develop an integrated nanoplatform for analysis of exosomes produced by host-pathogen interaction at the single cell level. This will be accomplished by engineering an innovative device involving plasmonic nanoparticles to probe exosomes molecular profiles over time. The intended outcome is a generic and robust platform for detailed molecular analysis of the consequences of cell-to-cell interactions. Single cell scale will greatly improve detection accuracy for heterogeneous cell populations. Benefits will include new knowledge of cell-to-cell communication and intellectual property in manufacturing, which will foster collaborations across institutions and Australian industry by providing new technological solutions.Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE220100846
Funder
Australian Research Council
Funding Amount
$418,388.00
Summary
Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a ne ....Ordering photon energy carriers for efficient upconversion. This project aims to tackle the major challenge of upconversion nanosystems – their brightness. It will centre on building a donor/acceptor-ordered nanosystem to improve the energy transfer efficiency in hybrid nanomaterials. This ordered system will significantly improve the brightness of hybrid nanoparticles at low irradiance. Expected outcomes include a fundamental understanding of energy transfer mechanisms at sub-nm scales and a new strategy to brighten the upconversion nanomaterials. This project should push upconversion nanoscience to a new generation and provide significant benefits in ultra-sensitive biomolecular assays and in vivo bioimaging.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH210100040
Funder
Australian Research Council
Funding Amount
$5,000,000.00
Summary
ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this ....ARC RESEARCH HUB FOR CONNECTED SENSORS FOR HEALTH. This Hub aims to develop, manufacture and deploy high-tech, cyber-secure, medically-certified IoT sensors to global health markets by integrating disparate Australian capabilities into a productive end-to-end value chain. This Hub expects to position Australia at the forefront of connected health by integrating sensor science with cyber-secure data analytics, regulatory approval and certified manufacturing capabilities. Expected outcomes of this Hub include advanced manufacturing capacity for connected sensors, strategic partnerships and commercialisation skills to translate sensors research to create economic benefits such as jobs and locally-made products for domestic and export markets, as well as improving the health of Australians.Read moreRead less
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Catalysts for hydrogen-free ammonia production by electrochemical method. This project aims to realise the next generation of ammonia production under ambient conditions without hydrogen feedstock. Through a combination of theoretical molecular-level understanding and experimental materials engineering, a range of catalysts will be developed under a materials discovery scheme for electrochemical nitrogen reduction to ammonia. These new catalysts, featuring high activity, efficiency, selectivity, ....Catalysts for hydrogen-free ammonia production by electrochemical method. This project aims to realise the next generation of ammonia production under ambient conditions without hydrogen feedstock. Through a combination of theoretical molecular-level understanding and experimental materials engineering, a range of catalysts will be developed under a materials discovery scheme for electrochemical nitrogen reduction to ammonia. These new catalysts, featuring high activity, efficiency, selectivity, and stability, will facilitate an alternative artificial nitrogen fixation technology powered by renewable energies. This technology will enable the production of green fertilisers and provide renewable energy storage, which are key environmental and energy challenges that Australia and the world currently face.Read moreRead less
Advanced lanthanide-doped nanomaterials for new-generation security inks. Current security labelling technologies using pattern coding (“barcoding”) and/or UV-excited phosphorescent inks are relatively easily counterfeited. The project aims to identify optimal design, fabrication and surface treatment of infrared-excited lanthanide nanoparticles for use as pigments in UV-curable polymer inks. This is expected to result in a new-generation of jet-printable security inks with ultimate capability f ....Advanced lanthanide-doped nanomaterials for new-generation security inks. Current security labelling technologies using pattern coding (“barcoding”) and/or UV-excited phosphorescent inks are relatively easily counterfeited. The project aims to identify optimal design, fabrication and surface treatment of infrared-excited lanthanide nanoparticles for use as pigments in UV-curable polymer inks. This is expected to result in a new-generation of jet-printable security inks with ultimate capability for multidimensional coding (using multiple luminescence wavelengths and lifetimes) and robust readability. Expected outcomes are world leadership in codable inks for secure labelling against counterfeiting, greatly enhancing both global ink-product sales and the value of Australian exports subject to product substitution.Read moreRead less
Next generation easy-clean lenses by robust liquid-repellent nanotextures. This project aims to produce better performing self-cleaning lenses, which are less likely to get dirty and are easy to clean. It will develop water and oil repellent coatings with superior optical transparency and mechanical, solvent and UV stability for both hard coated and anti-reflection coated optical lenses. Engineering of stable, ultra-liquid repellent nanomaterials on transparent surfaces will create a foundation ....Next generation easy-clean lenses by robust liquid-repellent nanotextures. This project aims to produce better performing self-cleaning lenses, which are less likely to get dirty and are easy to clean. It will develop water and oil repellent coatings with superior optical transparency and mechanical, solvent and UV stability for both hard coated and anti-reflection coated optical lenses. Engineering of stable, ultra-liquid repellent nanomaterials on transparent surfaces will create a foundation of knowledge for the industrial development of the future generation of easy care coatings, with vast application potential.Read moreRead less
Harnessing Interlayer Biexcitons in Atomically Thin Heterostructures. This project aims to investigate the generation of high-quality quantum light sources by harnessing interlayer biexcitons in atomically thin heterostructures. This research expects to expand our understanding of fundamental physics of photon pair generation in atomically thin heterostructures. The expected outcome is demonstration of a prototype light-weight and intense quantum photon source based on novel materials, which can ....Harnessing Interlayer Biexcitons in Atomically Thin Heterostructures. This project aims to investigate the generation of high-quality quantum light sources by harnessing interlayer biexcitons in atomically thin heterostructures. This research expects to expand our understanding of fundamental physics of photon pair generation in atomically thin heterostructures. The expected outcome is demonstration of a prototype light-weight and intense quantum photon source based on novel materials, which can be readily integrated with photonic circuits for quantum communication technologies, enbling the developments of light weight portable devices, such as mobile phones, displays, and wearable photonics. This research could strengthen the development of new industries and lead to job creation in Australia. Read moreRead less