Central nervous system cytokines and morphine analgesia. Morphine remains the drug of choice for the management of moderate-to-severe pain, however its clinical effectiveness is compromised by the fact that morphine's analgesic (pain reducing) efficacy becomes less effective the more it is administered.. This project will examine how analgesic tolerance develops from a completely new approach: Namely, how stimulation of the immune system within the central nervous system is a crucial factor in t ....Central nervous system cytokines and morphine analgesia. Morphine remains the drug of choice for the management of moderate-to-severe pain, however its clinical effectiveness is compromised by the fact that morphine's analgesic (pain reducing) efficacy becomes less effective the more it is administered.. This project will examine how analgesic tolerance develops from a completely new approach: Namely, how stimulation of the immune system within the central nervous system is a crucial factor in the development of tolerance. Modulation of analgesia by the immune system has not been systematically studied and provides a potentially fertile ground for the development of new techniques in the management of clinical pain.Read moreRead less
The effects of home-based couple relationship education on couple relationships, mental health and work performance. Marital distress and separations cause great suffering and cost the Australian community at least $5 billion annually. This research evaluates an innovative relationship education program that couples can complete at home. The research tests whether the education enhances couples' relationship satisfaction, which couples benefit, how the program achieves its effects, and whether i ....The effects of home-based couple relationship education on couple relationships, mental health and work performance. Marital distress and separations cause great suffering and cost the Australian community at least $5 billion annually. This research evaluates an innovative relationship education program that couples can complete at home. The research tests whether the education enhances couples' relationship satisfaction, which couples benefit, how the program achieves its effects, and whether improved couple relationships enhances partners' mental health and work performance. The program might provide national benefit in reducing the enormous personal and social costs of marital problems, as well as providing a potentially important new product with significant export potential.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE140100588
Funder
Australian Research Council
Funding Amount
$395,220.00
Summary
Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered gl ....Gene-environment interactions in the regulation of neuroplasticity and cognitive function . This project will study the effects of different housing conditions on neuroplasticity-related cognitive function by combining an innovative operant conditioning behavioural test (computerised touch-screen technology) and new molecular approaches. Potential gene-environment interactions will be revealed using genetically targeted mice which have never been assessed in that context (mutants with altered glucocorticoid and serotonin signalling). This project will study whether specific stages of the neuroplasticity process are differentially modulated through gene-environment interactions, ultimately resulting in changes to behaviour and cognitive functions. This will lead to a better understanding of the potential approaches that could be used to improve cognitive function.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101275
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Contribution of basal ganglia networks to the fine-tuning of action. This project aims to identify the changes occurring in specific brain circuits when new behaviours are learned. Our ability to perform efficient goal-directed actions involves a learning process in which separate movements are organised into sequences of action. This project aims to determine how this is encoded in the brain by mapping basal ganglia networks that are directly engaged during different stages of learning. This pr ....Contribution of basal ganglia networks to the fine-tuning of action. This project aims to identify the changes occurring in specific brain circuits when new behaviours are learned. Our ability to perform efficient goal-directed actions involves a learning process in which separate movements are organised into sequences of action. This project aims to determine how this is encoded in the brain by mapping basal ganglia networks that are directly engaged during different stages of learning. This project also seeks to identify specific neural circuits that are important for the refinement of action. The knowledge developed in this project is expected to support the development of training programs to instruct individuals in specialised tasks and may be used in the design of biologically inspired robots.Read moreRead less
Spatiotemporal signatures of learning in brain reward systems. Learning to strengthen behaviours that secure resources and warrant survival is one of the primary functions of the brain. This Project seeks to establish the rules that govern the integration of learning in brain reward systems by studying how neuronal circuits change their molecular signatures as animals assimilate new knowledge. These studies will combine novel experimental designs to investigate learning with multidisciplinary me ....Spatiotemporal signatures of learning in brain reward systems. Learning to strengthen behaviours that secure resources and warrant survival is one of the primary functions of the brain. This Project seeks to establish the rules that govern the integration of learning in brain reward systems by studying how neuronal circuits change their molecular signatures as animals assimilate new knowledge. These studies will combine novel experimental designs to investigate learning with multidisciplinary methods for mapping, recording and functionalising teaching signals in behaving mice. The outcomes will create a significant shift in our understanding of the neural bases that underlie reward learning, and will critically expand the field by providing a new model of learning integration in brain systems.Read moreRead less
Mechanisms of memory integration in brain systems. Learning from our interactions with the environment is one of the brain’s most important functions, yet how and where this process takes place at the neural network level has proven difficult to establish. This Project seeks to investigate how major neuromodulatory signals in the brain coordinate the encoding of reward-based learning in large ensembles of neurons. These studies will combine novel behavioural paradigms with the most recent neuros ....Mechanisms of memory integration in brain systems. Learning from our interactions with the environment is one of the brain’s most important functions, yet how and where this process takes place at the neural network level has proven difficult to establish. This Project seeks to investigate how major neuromodulatory signals in the brain coordinate the encoding of reward-based learning in large ensembles of neurons. These studies will combine novel behavioural paradigms with the most recent neuroscience techniques for functional mapping and manipulation of specific neural circuits in behaving mice. The outcomes of this research will lead to a significant shift in our understanding of the mechanisms underpinning the integration of learning in brain systems and its implications for behaviour.Read moreRead less
Role of shifting thalamostriatal networks in action refinement. This project aims to determine the changes occurring in specific brain circuits when automatic behaviours are established. Ability to acquire new skills depends on the dynamic reorganisation of particular neural networks across brain territories throughout training. This project seeks to investigate how the thalamus-to-striatum pathway, a neural circuit that is central to motor control, progressively adjusts its activity as animals ....Role of shifting thalamostriatal networks in action refinement. This project aims to determine the changes occurring in specific brain circuits when automatic behaviours are established. Ability to acquire new skills depends on the dynamic reorganisation of particular neural networks across brain territories throughout training. This project seeks to investigate how the thalamus-to-striatum pathway, a neural circuit that is central to motor control, progressively adjusts its activity as animals automatise their actions. The project will combine behavioural designs with the latest neuroscience techniques for tracing, functional mapping and manipulation of specific neural circuits in behaving mice. The outcomes of this project will lead to a better understanding of the mechanisms underpinning the refinement of action at the systems level, which is critical for performance and professional dexterity.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120100110
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Extinction of drug-seeking in adolescent rats. To investigate the ontogeny of drug abuse and its treatment, acquisition and treatment of drug-seeking behaviour will be examined in adolescent rats. I expect that adolescent rats will fail to inhibit drug-seeking behaviour, and show immaturity in cortical brain areas. Increasing cortical activity may rescue their ability to inhibit drug-seeking.
Pathways to work engagement, wellbeing and positive teaching among mid-career teachers: The role of personal and workplace resources. Teaching is a highly demanding, yet rewarding career for many. It is also a decidedly stressful occupation associated with high burnout. By following a large sample of teachers recruited ten years earlier into their mid-career, this project investigates the coping and motivational resources that keep them engaged, allowing them to thrive personally and professiona ....Pathways to work engagement, wellbeing and positive teaching among mid-career teachers: The role of personal and workplace resources. Teaching is a highly demanding, yet rewarding career for many. It is also a decidedly stressful occupation associated with high burnout. By following a large sample of teachers recruited ten years earlier into their mid-career, this project investigates the coping and motivational resources that keep them engaged, allowing them to thrive personally and professionally in different kinds of school environments, versus pathways that predict to burnout, ill-being and negative teaching behaviours. Selected subgroups who were most at risk and most positively engaged earlier in their career will be the focus of longitudinal case studies to uncover more nuanced processes promoting positive and negative pathways.Read moreRead less
Attracting and sustaining engaged science and mathematics teachers. Attracting and sustaining engaged science and mathematics teachers. This project will examine what attracts or deters potential, future and practising teachers of the sciences and mathematics, by focusing on current teachers, school and university students in Queensland. Promises of a technological revolution and rapid economic development will be hollow if students do not study sciences and mathematics, and there are too few qu ....Attracting and sustaining engaged science and mathematics teachers. Attracting and sustaining engaged science and mathematics teachers. This project will examine what attracts or deters potential, future and practising teachers of the sciences and mathematics, by focusing on current teachers, school and university students in Queensland. Promises of a technological revolution and rapid economic development will be hollow if students do not study sciences and mathematics, and there are too few qualified teachers. This project will identify where to intervene in the science and mathematics teacher supply pipeline, and policy levers to attract and sustain quality teachers. The project is expected to uncover what attracts or deters teachers of science and mathematics—disciplines essential to industry innovation, a skilled workforce and productivity growth.Read moreRead less