Formulating New Goals For Global Health And Proposing New Governance For Global Health That Will Allow The Achievement Of These Goals
Funder
National Health and Medical Research Council
Funding Amount
$469,017.00
Summary
The Millennium Development Goals have guided global development since 2000, and are due for evaluation in 2015. Attention is now turning to New Health-Related Goals, with a governance structure to support their implementation. Australian researchers are joining a Go4Health consortium of 13 research institutions to research the development of these goals, examining the input of United Nations agencies and key donors into the process, together with communities, civil society and governments.
LIFEPATH: Life-course Biological Pathways Underlying Social Differences In Healthy Ageing
Funder
National Health and Medical Research Council
Funding Amount
$470,466.00
Summary
Healthy ageing varies across society due to environmental, behavioural and social circumstances that affect peoples’ lives. To improve our ability to change this we will investigate suspected biological mechanisms over the life course. Using repeated blood samples collected during a large prospective study, we will measure a very large number of biological markers and analyse these combined with lifestyle and behavioural information to identify the modifiable predictors of healthy ageing.
Improving Nutrition And Health Outcomes For Women And Babies In The Aboriginal Family Birthing Program
Funder
National Health and Medical Research Council
Funding Amount
$975,882.00
Summary
Young Aboriginal women are more likely to have children when they are under 25 than other women in SA. They are also much more likely to be overweight or obese. Together these two characteristics have profound consequences for a woman's health and increased risks for poor birth outcomes. A novel package of culturally appropriate and intensive nutrition strategies, embedded in the SA Aboriginal Family Birthing Program will be developed and assessed to see its impact on women's and child health.
Hendra virus (HeV) cause a disease transmitted from bats to horses which in turn infect humans and other horses. There are no drugs or vaccines for HeV. Since humans are infected by inhalation, a vaccine that can generate antibody in the lung and protect from infection will be ideal. We have found that a natural sugar called mannan used with virus proteins and administered via the nostrils to generate such responses. In this project we will prepare this vaccine and use it in a mouse model of HeV ....Hendra virus (HeV) cause a disease transmitted from bats to horses which in turn infect humans and other horses. There are no drugs or vaccines for HeV. Since humans are infected by inhalation, a vaccine that can generate antibody in the lung and protect from infection will be ideal. We have found that a natural sugar called mannan used with virus proteins and administered via the nostrils to generate such responses. In this project we will prepare this vaccine and use it in a mouse model of HeV infection to see if it can protect the mice.Read moreRead less
Developing A National Salt Reduction Program For India
Funder
National Health and Medical Research Council
Funding Amount
$935,028.00
Summary
Excess dietary salt is a leading cause of premature strokes and heart attacks around the world. India, the world’s second most populous nation has no coordinated national salt reduction program and lacks key data upon which to formulate a strategy. This research will bring together Australian experts in the field with leading Indian researchers to make the baseline assessments required to formulate and commence population-wide salt reduction efforts in India.
This proposal uses the zebra fish system, which it is uniquely suited to investigate the regulation of disease genes. In all of these diseases preliminary work has already been performed and screening assays have been developed in a previous project (ZF-MODELS). In addition, the project will investigate genetic abnormalities of the eye and visual processing, genetic pathways underlying tissue regeneration and repair, and homologs of human genes related to diabetes and obesity, as well as infecti ....This proposal uses the zebra fish system, which it is uniquely suited to investigate the regulation of disease genes. In all of these diseases preliminary work has already been performed and screening assays have been developed in a previous project (ZF-MODELS). In addition, the project will investigate genetic abnormalities of the eye and visual processing, genetic pathways underlying tissue regeneration and repair, and homologs of human genes related to diabetes and obesity, as well as infectious disease and cancer. The Australian component will perform a systematic characterisation of enhancer elements of potential disease genes. This characterisation will build on the concept of genomic regulatory blocks (GRBs) which contain highly conserved non-coding elements (HCNEs) acting as long-range enhancers of developmental genes (recently discovered by T. Becker in the ZF-MODELS project).Read moreRead less
A Multi-ethnic Cohort And Intervention Trial To Identify Early Biomarkers For Type 2 Diabetes And Customise Individualized Environments For Disease Prevention
Funder
National Health and Medical Research Council
Funding Amount
$597,376.00
Summary
Diabetes is often called a lifestyle disease, however, large clinical studies have shown that diabetes cannot always be prevented through lifestyle modification. This collaborative study between Shanghai Institutes of Biological Science and Sydney University will identify biomarkers that predict the development of type 2 diabetes. Using this knowledge, the best interventions (including diet, exercise and medications) to improve an individual’s risk profile for type 2 diabetes will be identified.
LIFECYCLE - Early Life Stressors And LifeCycle Health
Funder
National Health and Medical Research Council
Funding Amount
$453,811.00
Summary
Early in life is a period of time during which we can institute changes that can have long lasting benefits for asthma, obesity, diabetes mellitus and mental and cardiovascular health. The current project, LIFECYCLE is a cooperative project with a combined total of a quarter of a million participants, which will be the definitive study to determine, which early life events should be modified for improving health trajectories throughout life.
OptiMalVax: Optimizing A Deployable High Efficacy Malaria Vaccine
Funder
National Health and Medical Research Council
Funding Amount
$494,618.00
Summary
In this proposal, a consortium comprising many of the leading malariologists, vaccine researchers and product developers in Europe, USA, Australia and Africa will collaborate in an exciting programme of antigen discovery science linked to rapid clinical development of new vaccine candidates against malaria.
Indigenous Network Suicide Intervention Skills Training (INSIST): Can A Community Designed And Delivered Framework Reduce Suicide/self-harm In Indigenous Youth?
Funder
National Health and Medical Research Council
Funding Amount
$828,215.00
Summary
Queensland has the highest rates of youth suicide in Australia. Indigenous youth suicide rates are reported at twice the rate of Queensland’s total population for 15 to 44 years. Statistical data on urban-rural differences in Australia have only been available since 1986 (ABS, 1994). Although the number of suicides is far greater in urban areas (1,299 suicides aged 10–24 years in metropolitan areas versus 311 in towns with populations less than 4,000), rural demonstrate greater suicide rates per