Technology is changing the lives of Australians. We need to understand the impact on health to gain the benefits with minimal harm. This fellowship will support a program of internationally leading research drawing together ergonomics, physiotherapy and physical activity expertise. Example projects include the impact of electronic games on children’s activity, walking workstations to increase physical activity of office workers and a family-based program for overweight adolescents.
Transcriptional Control Of Blood Vessel Development By Sox18
Funder
National Health and Medical Research Council
Funding Amount
$468,564.00
Summary
Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of ....Blood vessels play an essential role in maintaining the supply of nutrients to every organ and tissue in the body. Improper development of blood vessels in the embryo can compromise survival of the embryo, and defects in the ability of blood vessels to grow, regenerate and adapt to change during adult life can be life-threatening. The growth of new blood vessels (angiogenesis) is also an important factor in the ability of solid tumours to grow during the progression of cancer. It is therefore of fundamental importance in the health sciences to gain an understanding of how blood vessels form and regenerate. As a result of our collaborative research efforts, we have discovered a gene, Sox18, that appears to regulate blood vessel development by controlling the formation and-or behaviour of endothelial cells, which line the blood vessels and make them impermeable. Our research so far indicates that MICE WITH DEFECTS IN SOX18 DIE FROM VASCULAR DEFECTS, underlining the importance of this gene. THIS PROJECT IS CONCERNED WITH FINDING OUT HOW SOX18 WORKS - exactly what goes wrong in mice lacking this gene, whether Sox18 can influence endothelial cell behaviour in cell culture, how Sox18 comes to be active in endothelial cells, what genes are switched on by Sox18, and what genes Sox18 co-operates with in its role in endothelial cells. The answers to these questions will not only provide fundamental basic information about how blood vessels development is controlled, but also sow the seeds for possible future therapies in which blood vessel development could be stimulated (eg in wound healing) or suppressed (eg in tumour progression) through pharmaceutical intervention.Read moreRead less
Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
Mid-Career Industry Fellowships - Grant ID: IM230100702
Funder
Australian Research Council
Funding Amount
$859,472.00
Summary
Optimising sleep, alertness and safety in shift work industries. This project aims to address the impaired alertness, and high risk of workplace errors and accidents that are associated with sleep loss and circadian misalignment during shift work. The project will deliver an innovative industry-driven digital technology to provide automated, customised sleep management strategies to shift workers, and will develop a framework for effective wide-scale deployment of the technology within Australia ....Optimising sleep, alertness and safety in shift work industries. This project aims to address the impaired alertness, and high risk of workplace errors and accidents that are associated with sleep loss and circadian misalignment during shift work. The project will deliver an innovative industry-driven digital technology to provide automated, customised sleep management strategies to shift workers, and will develop a framework for effective wide-scale deployment of the technology within Australian shift working organisations. The project will close the gap in resources currently available to support sleep in shift workers and will reduce the significant burdens of shift work for alertness, productivity and safety.Read moreRead less
The Transmission Of Perinatal Maternal Mental Health To Preschool Emotional Disorders: Examining Pathways And Intervention Points In The MPEWS Study
Funder
National Health and Medical Research Council
Funding Amount
$970,795.00
Summary
While it is known that depression, anxiety and stress in pregnancy increase the risk for poorer child mental health, what is unknown is the key pathways and intervention points to prevent this transmission of risk. This study will examine potential mechanisms and intervention points through a selected cohort study: Mercy Pregnancy and Emotional Wellbeing Study. This study follows 500 women and their children from first trimester in pregnancy until the children are 3 years of age.
Mid-Career Industry Fellowships - Grant ID: IM230100042
Funder
Australian Research Council
Funding Amount
$980,358.00
Summary
Unlocking the full reproductive potential for hybrid wheat breeding. Globally, wheat is cultivated as an inbred self-fertile crop with yield gains stagnating over the last decades. This contrasts with unabated yield gains and yield stability achieved for rice and corn through hybrid breeding and cross-pollination. Wheat hybrids hold potential for a 10-22% yield boost, but commercial deployment is restricted due to high seed production costs, a result of wheat’s floral architecture and poor outcr ....Unlocking the full reproductive potential for hybrid wheat breeding. Globally, wheat is cultivated as an inbred self-fertile crop with yield gains stagnating over the last decades. This contrasts with unabated yield gains and yield stability achieved for rice and corn through hybrid breeding and cross-pollination. Wheat hybrids hold potential for a 10-22% yield boost, but commercial deployment is restricted due to high seed production costs, a result of wheat’s floral architecture and poor outcrossing characteristics. This project aims to reduce costs by improving wheat’s female receptivity to airborne pollen, a major bottleneck to commercial realization of hybrids globally. Higher and more stable yields from wheat hybrids will ensure food security in the face of climate uncertainty and growing population.Read moreRead less
Do Exposures Before Conception Influence The Risk Of Asthma In Offspring?
Funder
National Health and Medical Research Council
Funding Amount
$688,586.00
Summary
Asthma and poor lung function are major causes of public health issues. Emerging evidence suggests adverse exposures even before the conception of a child may cause these conditions. The proposed project is part of an international study across generations to identify these factors. This study will provide novel evidence to guide interventions and identify studies to advance this area further. These original findings will be of great importance both nationally and internationally.
Promoting engagement with life in older adulthood. This project aims to examine engagement in meaningful activities among older adults. Increasing older adults' engagement could promote direct benefits for social integration, well-being and better quality of life. The project is expected to generate new knowledge on programs that effectively promote engagement, as well as evaluating a new tailored approach to promoting engagement that aligns with individuals' unique strengths, capabilities and ....Promoting engagement with life in older adulthood. This project aims to examine engagement in meaningful activities among older adults. Increasing older adults' engagement could promote direct benefits for social integration, well-being and better quality of life. The project is expected to generate new knowledge on programs that effectively promote engagement, as well as evaluating a new tailored approach to promoting engagement that aligns with individuals' unique strengths, capabilities and values. The findings aim to provide benefits for community organisations and aged care service providers adopting innovative approaches to promoting ageing well.
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Understanding And Overcoming Cardiovascular And Diabetes Inequalities In Indigenous Australians
Funder
National Health and Medical Research Council
Funding Amount
$707,370.00
Summary
Aboriginal and Torres Strait Islanders experience the highest rates of heart disease and diabetes of all Australians. The reasons for this large disparity is not yet fully understood. I propose to investigate the patterns, causes, complications and links between heart disease and diabetes in Indigenous populations to identify better ways of managing and preventing chronic disease in high risk communities.
Genome-wide Association Study (GWAS) For Juvenile-onset Myopia And Its Component Measures To Identify Molecular Pathways To Prevent Myopia
Funder
National Health and Medical Research Council
Funding Amount
$495,364.00
Summary
We will examine 2,000 young adults from the Western Australian Raine Cohort at the Lions Eye Institute / University of Western Australia. Ocular data will be collected relating to myopia (short-sightedness) and will be combined with extensive previous childhood and genetic research data collected on the Cohort, to investigate the genetic and environmental factors predisposing to myopia. This will assist in understanding the factors leading to myopia.