An Examination Of Motor Functioning In Autism And Asperger's Disorder: An Analysis Of Gait & Cortical Brain Activity.
Funder
National Health and Medical Research Council
Funding Amount
$120,220.00
Summary
Autism is a developmental disorder characterised by a triad of deficits: delayed and atypical language development, impaired development of social skills, and ritualistic and stereotypic behaviour. Although not part of the standard diagnosis, movement disorders and gait abnormalities have been clinically observed in autism similar to those seen in Parkinson's disease. In addition, individuals with Asperger's disorder may appear more clumsy, have a stiff or awkward way of walking, and exhibit poo ....Autism is a developmental disorder characterised by a triad of deficits: delayed and atypical language development, impaired development of social skills, and ritualistic and stereotypic behaviour. Although not part of the standard diagnosis, movement disorders and gait abnormalities have been clinically observed in autism similar to those seen in Parkinson's disease. In addition, individuals with Asperger's disorder may appear more clumsy, have a stiff or awkward way of walking, and exhibit poor coordination in posture and gesture. It has been suggested that there is disruption within the basal-ganglia-thalamocortical circuitry (the region connecting the frontal and sub-cortical structures), which may cause the motor dysfunction seen in autism and Asperger's disorder. Few studies have attempted to isolate particular stages of motor functioning which may account for the coordination and motor delay observed clinically in autism and Asperger's disorder. A recent study of ours found evidence to suggest that motor planning deficiencies may account for the 'clumsy' movement patterns frequently reported in the autism - Asperger's disorder literature. Therefore, the aim of this research is to provide a comprehensive neurobehavioural and neurophysiological analysis of motor functioning in young people with autism and Asperger's disorder to further examine the exact stages of motor processing which are deficient in these disorder groups. Recent retrospective studies have shown that even as infants children with autism exhibit clear features of motor disturbance, which, if detected and clearly defined, could advance early diagnosis. In addition to advancing the clinical definition of autism and Asperger's disorder, a careful examination of motor disturbance may also illuminate the neurobiological underpinnings of these disorders.Read moreRead less
Vulnerability to cocaine use: discovering common mechanisms conserved across animal phyla. Drug abuse costs Australia an estimated $ 20 billion each year, and research is urgently needed to understand how drugs cause long-term behavioural dysfunction. Our research will identify the basal cellular mechanisms underlying drug abuse and addiction, which are likely to be the best targets for therapies to prevent and cure addiction. Our findings are also relevant to other neuropsychiatric disorders r ....Vulnerability to cocaine use: discovering common mechanisms conserved across animal phyla. Drug abuse costs Australia an estimated $ 20 billion each year, and research is urgently needed to understand how drugs cause long-term behavioural dysfunction. Our research will identify the basal cellular mechanisms underlying drug abuse and addiction, which are likely to be the best targets for therapies to prevent and cure addiction. Our findings are also relevant to other neuropsychiatric disorders related to drug abuse (e.g. depression, anxiety) that are on the increase in Australia. Our work will enhance Australia's reputation for neuroscience research, and will provide training for students in neuropharmacology and molecular neurobiology.Read moreRead less
Deciphering The Role Of Atypical DNA Methylation In Neuronal Genome Regulation And Neurological Disorders
Funder
National Health and Medical Research Council
Funding Amount
$773,484.00
Summary
This research will use a combination of genomic, biochemical and functional genomics approaches to investigate the role of the atypical mCH form of DNA methylation in neuronal genome regulation and function, and provide new insights into the role of the epigenome in healthy brain function and neural pathologies.
Discovery Early Career Researcher Award - Grant ID: DE200100164
Funder
Australian Research Council
Funding Amount
$387,551.00
Summary
How do neural circuits coordinate to produce adaptive changes in behaviour? This project aims to discover how neurons alter their function in coordinated ways to produce adaptive changes in behaviour. Behavioural outputs result from the activity of multiple cells in a functional network, but current methods are limited to studying signalling effects on single neurons. To address this, I will develop new methods to visualise every cell in the brain of the living nematode worm to provide a unique ....How do neural circuits coordinate to produce adaptive changes in behaviour? This project aims to discover how neurons alter their function in coordinated ways to produce adaptive changes in behaviour. Behavioural outputs result from the activity of multiple cells in a functional network, but current methods are limited to studying signalling effects on single neurons. To address this, I will develop new methods to visualise every cell in the brain of the living nematode worm to provide a unique systems-level understanding of a model brain. Through collaboration with engineers and psychologists, I will describe molecular switches that trigger reorganisation of entire neural networks. Expected outcomes include new insights on neural circuit plasticity, which will advance discovery in neuroscience and robotics.Read moreRead less
Anandamide activated chloride channels in sensory neurons. We are seeking to understand how the nerve cells that sense our environment are regulated by signalling molecules produced by our body. Understanding how these cells function in normal conditions is essential as basis for understanding how they may function abnormally in physically stressful situations or in chronic pain conditions. The work may eventually lead to better treatments for a wide range of disorders that involve the sensory ....Anandamide activated chloride channels in sensory neurons. We are seeking to understand how the nerve cells that sense our environment are regulated by signalling molecules produced by our body. Understanding how these cells function in normal conditions is essential as basis for understanding how they may function abnormally in physically stressful situations or in chronic pain conditions. The work may eventually lead to better treatments for a wide range of disorders that involve the sensory nervous system. Read moreRead less
Evolution of intelligence in small brains: how to navigate the messy natural outdoors smartly. This project unravels how small-brained desert ants navigate expertly using simple and coarse-grade visual cues, focusing on 1) how they use skylines, where the tops of terrestrial objects meet the sky, and 2) how they search efficiently for goals. The outcomes will be invaluable for designing robots that can navigate in the messy natural outdoors.
Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an ....Early stress experiences and stress resilience in pigs. Animal stress has substantial implications on animal productivity, health and welfare of farm animals and thus farm profitability. This project aims to examine the stress resilience in pigs. Modern pig farming is a major source of food, providing substantial nutritional, social and economic benefits in Australia and worldwide. Animal welfare is of increasing concern to the public, consumers and pork producers, and stress vulnerability is an animal health and production problem in the life of the commercial pig. This project will generate new knowledge on early life management to endow stress resilience in pigs, with expected benefits for animal welfare, farm productivity and profitability.Read moreRead less
Becoming expert navigators with tiny brains: Learning in desert ants. Desert ants with tiny brains learn to use their surrounding visual landscape to navigate. This project investigates in detail how they do that in a few carefully orchestrated trips around their nest called learning walks. Desert ants are known now to use magnetic cues to orient during their learning walks. The project also probes the role that magnetic cues play in the ants’ learning, as well as the sensory basis of the percep ....Becoming expert navigators with tiny brains: Learning in desert ants. Desert ants with tiny brains learn to use their surrounding visual landscape to navigate. This project investigates in detail how they do that in a few carefully orchestrated trips around their nest called learning walks. Desert ants are known now to use magnetic cues to orient during their learning walks. The project also probes the role that magnetic cues play in the ants’ learning, as well as the sensory basis of the perception of magnetic cues. Geomagnetic cues in the area of the nest will be artificially manipulated to test how ants use this cue. Probing the use of magnetic cues has potential benefits for projects of artificial autonomous navigation in situations when visual cues are unavailable, such as exploring a deep mine.
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Evolution, learning, and the use of multiple cues in desert ant navigation. This research on desert ants benefits Australia by fostering an international collaboration with one of the best European scientists, training students, and increasing knowledge about Australia's unique fauna, helping us to appreciate and better manage our fragile desert environments. With this international link, students working on this and related projects benefit intellectually from mingling with an international com ....Evolution, learning, and the use of multiple cues in desert ant navigation. This research on desert ants benefits Australia by fostering an international collaboration with one of the best European scientists, training students, and increasing knowledge about Australia's unique fauna, helping us to appreciate and better manage our fragile desert environments. With this international link, students working on this and related projects benefit intellectually from mingling with an international community of scientists.Understanding insect behaviour also has benefits for robotics. Work on desert ants has already resulted in robotic applications, and our outcomes concerning the optimal integration of multiple spatial cues are especially relevant.Read moreRead less
Towards a behavioural ecology of navigational memories in desert ants. Navigational memories (path integration, systematic search, and landmark use) in a Central Australian desert ant (Melophorus bagoti) and a North African desert ant (Cataglyphis fortis) are studied at the ants? natural habitats. The project tests predictions about behavioural properties of memory (how quickly it can be acquired, how long it lasts, and how a conflicting event affects it), based on a cost-benefit analysis of the ....Towards a behavioural ecology of navigational memories in desert ants. Navigational memories (path integration, systematic search, and landmark use) in a Central Australian desert ant (Melophorus bagoti) and a North African desert ant (Cataglyphis fortis) are studied at the ants? natural habitats. The project tests predictions about behavioural properties of memory (how quickly it can be acquired, how long it lasts, and how a conflicting event affects it), based on a cost-benefit analysis of the functions of each memory system. The project launches the first systematic cost-benefit analysis of memory, to establish a behavioural ecology of memory. We hope that it inspires cost-benefit analyses of other functions of the brain.Read moreRead less