Developing An Evidence Base For The Psychological Care Of Children And Families Affected By Congenital Heart Disease.
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
Heart disease affects 1 in every 100 babies, making it one of the most common illnesses in infancy. Diagnosis and treatment of childhood heart disease often causes significant stress and trauma for children and their families. If support is not provided early, children can experience ongoing physical, emotional, and developmental problems. This program is built on a successful history of work and will improve child and family outcomes associated with heart disease through national and internatio ....Heart disease affects 1 in every 100 babies, making it one of the most common illnesses in infancy. Diagnosis and treatment of childhood heart disease often causes significant stress and trauma for children and their families. If support is not provided early, children can experience ongoing physical, emotional, and developmental problems. This program is built on a successful history of work and will improve child and family outcomes associated with heart disease through national and international research collaborations.Read moreRead less
The adult heart has an extremely limited capacity for regeneration. In contrast, I recently discovered that the newborn heart can completely regenerate following a heart attack. How and why the heart loses this regenerative capacity after birth is not known. This Fellowship aims to unravel the genetic circuits that govern cardiac regenerative capacity. The proposed research program will develop novel therapies for heart regeneration through molecular targeting of regulatory RNA molecules.
Targeting Central Inflammation To Combat Obesity And Obesity-related Cognitive Dysfunction
Funder
National Health and Medical Research Council
Funding Amount
$470,144.00
Summary
The current obesity epidemic means many of us will suffer from overweight or obesity for at least some of our lives. My findings show obesity can cause inflammation throughout the brain including in regions related to learning and memory. Here I hypothesize that obesity induces long-term changes in the brain’s immune cells, that this can explain why we see susceptibility to cognitive decline in obese individuals, and that we can reverse these negative effects by targeting these immune cells.
Using Human 3D Engineered Heart Tissue For Discovery Of Novel Biology And Novel Therapeutics
Funder
National Health and Medical Research Council
Funding Amount
$425,048.00
Summary
The goal of this project is to develop a model of miniaturised 3D human heart tissue for research into cardiac biology and also drug discovery applications. This will hopefully result in better, cheaper drugs in the future with less reliance on animal testing.
Molecular Targets Involved In Human Muscle Atrophy And Hypertrophy
Funder
National Health and Medical Research Council
Funding Amount
$380,558.00
Summary
Muscle wasting is a consequence of aging, cancer, HIV-AIDS, obesity and work-sport injuries. It increases the risk of injury, impacts on recovery and places an economic burden on our healthcare system. Atrogin-1 and STARS are muscle specific genes believed to regulate muscle mass. This project aims to determine how human atrogin-1 and STARS are regulated and how they can influence muscle loss. These studies may provide new targets for reducing human muscle wasting.