A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on th ....A novel regulator of growth signalling in Drosophila. This project aims to increase understanding of how growth is regulated by growth factor hormones. In animals, growth is controlled by signalling pathways that are activated by secreted peptide hormones. A new regulator of growth in the fruitfly Drosophila, the membrane attack complex/perforin-like (MACPF) protein Torso-like, has been identified. The project aims to unravel how Torso-like functions to regulate growth, thus throwing light on the role this protein family may play in all animals. The findings are expected to provide key insights into the modification of growth factor activity, which is often dysregulated in human cancers and growth disorders, and may enable the design of new strategies for interfering with insect development for pest control.Read moreRead less
Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters ....Redefining the molecular mechanism underlying crustacean metamorphosis. This project uses the astonishing lifecycle of lobster larvae to better define the pathways and discover the key genes that regulate crustacean metamorphosis. Where, when, why and how metamorphosis occurs in crustaceans are important factors affecting fisheries recruitment and aquaculture production. The project suggests that the current accepted paradigm for the molecular control of metamorphosis does not apply to lobsters and possibly other crustaceans where larval metamorphosis and the juvenile transformation are uncoupled. Using a unique supply of cultured lobsters and advanced molecular techniques, the project aims to develop tools to trigger and synchronise metamorphosis for use in aquaculture and invasive species management.Read moreRead less
Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable ....Turning back the clock on brain cell aging. This proposal aims to determine the role of fundamental epigenetic mechanisms in the process of aging and whether modulation of the epi-genome underpins an improvement in cognitive function. It combines the fields of epigenetics, neurosciences and mathematics to delineate the dynamics of DNA methylation and histone modification marking on the transcriptome during normal, healthy aging. The outcomes will provide significant new knowledge of the variable cognitive decline that occurs in healthy aging and why some populations age less successfully than others do. Better understanding of the impact of environmental change on the biology of aging has potential community benefits.Read moreRead less
The genetics of adaptation: changing developmental trajectories in eucalypts. During their life cycles, many animals and plants undergo genetically programmed changes in form. Such changes may be dramatic and rapid as seen in insect metamorphoses or plant heteroblasty, and may have ecological, evolutionary and even economic consequences. The project aims to identify the genes controlling such transitions in Australia's eucalypts.
Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two k ....Transitions between modes of sex-determination in a changing world. Sex-determination controls the largest variation within animals—the division into males and females. While the different systems of sex-determination—involving genetic or environmental control—are fairly well understood, transitions between these systems remain enigmatic in evolutionary biology. This project aims to address this gap by revealing the molecular change required to transition between systems, using one of only two known lizard species exhibiting both genetic and temperature control of sex. This knowledge will have important implications for species conservation, facilitating predictions of highly biased sex ratios under climate change, plus potential commercial applications for species where production of one sex is favoured.Read moreRead less
Evolution, disease and extinction - using ancient and modern Deoxyribonucleic acid (DNA) to investigate molecular evolution in the Tasmanian devil. The Tasmanian devil is Australia's largest living marsupial carnivore and one of Tasmania's key tourism icons. Extinction in the wild will have long-term impacts on Tasmanian native ecosystems and economy. This study will provide critical genetic data and tools to monitor and prioritise conservation strategies, including insurance populations and dis ....Evolution, disease and extinction - using ancient and modern Deoxyribonucleic acid (DNA) to investigate molecular evolution in the Tasmanian devil. The Tasmanian devil is Australia's largest living marsupial carnivore and one of Tasmania's key tourism icons. Extinction in the wild will have long-term impacts on Tasmanian native ecosystems and economy. This study will provide critical genetic data and tools to monitor and prioritise conservation strategies, including insurance populations and disease suppression, aimed at preventing extinction. It will strengthen ongoing conservation programs carried out by the Save the Tasmanian Devil Program and will help publicise the plight of the devil both nationally and internationally.Read moreRead less
Genetics of species differentiation and hybridisation in Eucalyptus. This project aims to use state-of-the-art genomic technologies to characterise genes and genomic regions important for speciation and adaptation in Australia’s iconic eucalypts, and study the importance of hybridisation between species, especially during range expansion and contraction. A major international effort has seen a eucalypt become the second forest tree genome sequenced. This project aims to link the expanding intern ....Genetics of species differentiation and hybridisation in Eucalyptus. This project aims to use state-of-the-art genomic technologies to characterise genes and genomic regions important for speciation and adaptation in Australia’s iconic eucalypts, and study the importance of hybridisation between species, especially during range expansion and contraction. A major international effort has seen a eucalypt become the second forest tree genome sequenced. This project aims to link the expanding international knowledge on the eucalypt genome to the evolutionary dynamics of wild populations in Australia to provide unprecedented insights into the nature of species and processes which have shaped their evolution. These insights may inform their breeding as well as their conservation and management in Australia.Read moreRead less
From genes to ecosystems: does genetic divergence in eucalyptus alter biodiversity and ecosystem function? The project will use a dominant tree species of south-eastern Australia to examine how genetic based variation in its traits influences community organisation, biodiversity and ecosystem processes. Outcomes from this research will be important for responding to an uncertain future environment and maintaining the services ecosystems provide.
Genetic impacts on eucalypt forest biodiversity. Australia is the centre of origin for most of the world's eucalypt genetic resources. This project will provide the research required to develop management strategies to reduce the risk of genetic pollution of this important genetic resource from the expanding eucalypt plantings in Australia. It will provide leading-edge science to better assess the risk and impact of genetic pollution not only on the native eucalypt gene pools per se but also on ....Genetic impacts on eucalypt forest biodiversity. Australia is the centre of origin for most of the world's eucalypt genetic resources. This project will provide the research required to develop management strategies to reduce the risk of genetic pollution of this important genetic resource from the expanding eucalypt plantings in Australia. It will provide leading-edge science to better assess the risk and impact of genetic pollution not only on the native eucalypt gene pools per se but also on the structure and biodiversity of the fungi, insect and vertebrate communities that are dependent on the eucalyptsRead moreRead less
Unravelling the relationship between growth and wood properties in temperate eucalypts. The most important biological traits affecting profit in eucalypt plantations grown for pulpwood are growth, wood density and pulp yield. Shrinkage and collapse are important for timber production. Little information is available on the size and direction of the correlations between these traits, yet they are important in determining selection response in breeding as well as environmental impacts on pulp and ....Unravelling the relationship between growth and wood properties in temperate eucalypts. The most important biological traits affecting profit in eucalypt plantations grown for pulpwood are growth, wood density and pulp yield. Shrinkage and collapse are important for timber production. Little information is available on the size and direction of the correlations between these traits, yet they are important in determining selection response in breeding as well as environmental impacts on pulp and sawlog yield. The collaborating growers and breeders have brought together a unique base of Eucalyptus globulus and E. nitens field trials that will allow an integrated quantitative and molecular genetic study of the interrelationships amongst these key profit traits.Read moreRead less