The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which ....The Epigenetics of Sex in the Dragon. Genetic codes do not directly translate to phenotypes -- environment acts through epigenetics to modify development. We use advanced molecular techniques to examine how epigenetics responds to temperature to reverse sex in our novel animal model, the dragon lizard. How does the cell sense temperature? Once the extrinsic signal is captured, how does it influence chromatin modification to release or suppress key genes in the sex differentiation pathway? Which sex genes are targets? Epigenetic enzymes are astonishingly conserved, providing exciting opportunities to draw from human systems to unravel novel signatures of temperature-induced sex switching in reptiles. This project will advance knowledge of developmental programming generally.Read moreRead less
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in thei ....Effectiveness of social skills training for children with autism. Our industry partner, Aspect Australia, is one of the world's largest providers of educational and other services for people with autism. The demonstration of effectiveness of the program in Aspect classes will likely lead to widespread use and benefit of the program in the education sector nationally and internationally. This in turn would lead to potential lessening of disability in children with autism with improvements in their mental health and significant cost savings to the community.Read moreRead less
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH130200013
Funder
Australian Research Council
Funding Amount
$4,979,922.00
Summary
ARC Research Hub for advanced breeding to transform prawn aquaculture. ARC Research Hub for advanced breeding to transform prawn aquaculture. This Research Hub aims to bring together world-leading animal geneticists, research and service providers, and Australia's largest prawn farm to gather the genomic resources, commercial phenotypic data, and apply cutting-edge genetic and genomic selection methodologies, leading to the transformative improvement program for a black tiger prawn aquaculture s ....ARC Research Hub for advanced breeding to transform prawn aquaculture. ARC Research Hub for advanced breeding to transform prawn aquaculture. This Research Hub aims to bring together world-leading animal geneticists, research and service providers, and Australia's largest prawn farm to gather the genomic resources, commercial phenotypic data, and apply cutting-edge genetic and genomic selection methodologies, leading to the transformative improvement program for a black tiger prawn aquaculture species globally.Read moreRead less
ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will ad ....ARC Centre of Excellence for Children and Families over the Life Course. New solutions are needed to underpin the Australian social ideal of a fair go, and to drive future global economic productivity. The Australian Productivity Commission identifies deep and persistent disadvantage as a significant problem in Australia given the failure of growing national prosperity over the past two decades to benefit underprivileged Australians. Social disadvantage is a global challenge. This Centre will advance basic, applied and translational research to reduce intergenerational and long-term disadvantage. Through the maturation of longitudinal datasets and advanced data integration we can follow the journeys of Australian families over generations and across the life course. This data will provide evidence for new policies and make a real difference to the lives of children and families.Read moreRead less
Upholding the right to cultural connection for children in care. A positive sense of cultural identity is critical to wellbeing, yet children in out-of-home care often lose their cultural identities and connections. There is little evidence to guide out-of-home care agencies to support a culturally meaningful foster care placement for non-Indigenous culturally and linguistically diverse children. This project tests promising practices identified by the partner organisations and research literatu ....Upholding the right to cultural connection for children in care. A positive sense of cultural identity is critical to wellbeing, yet children in out-of-home care often lose their cultural identities and connections. There is little evidence to guide out-of-home care agencies to support a culturally meaningful foster care placement for non-Indigenous culturally and linguistically diverse children. This project tests promising practices identified by the partner organisations and research literature to produce an exemplary model of cultural care, with input from children, carers and birth families. Trial implementation in the partner organisations will inform guidelines and recommendations so that the model can inform policy and practice in out-of-home care across Australia.
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ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for ....ARC Centre of Excellence in Population Ageing Research. This Centre intends to generate crucial knowledge to inform social and economic responses to population ageing, one of the most important issues of the 21st century. Population ageing exerts unprecedented pressures on social norms and policy institutions, both in Australia and around the world. Leading researchers from a range of disciplines will undertake multidisciplinary research to help governments, businesses, and consumers prepare for and make better decisions for an ageing world, with consequent social and economic benefits for families and communities expected to flow to Australia, the Asian region and the world.Read moreRead less