Oxygen Signalling in Grapevine Bud Dormancy. Dormancy is an important economic and ecological trait of many trees and crop plants, including most commercially valuable fruit species. This project aims to: define oxygen and radicals of oxygen as central cues of grapevine bud development and dormancy; identify and model the developmental processes that occur during dormancy onset, maintenance and release (bud burst); as well as to identify the molecular and biochemical regulators of oxygen signals ....Oxygen Signalling in Grapevine Bud Dormancy. Dormancy is an important economic and ecological trait of many trees and crop plants, including most commercially valuable fruit species. This project aims to: define oxygen and radicals of oxygen as central cues of grapevine bud development and dormancy; identify and model the developmental processes that occur during dormancy onset, maintenance and release (bud burst); as well as to identify the molecular and biochemical regulators of oxygen signals in bud dormancy. The knowledge generated could provide a platform to test impacts of climate change on fruit and tree species, and lead to better management of fruit and tree species in agricultural and ecological systems.Read moreRead less
Identifying The Pathological Mechanism Of PCDH19-Girls Clustering Epilepsy
Funder
National Health and Medical Research Council
Funding Amount
$523,988.00
Summary
Changes in the PCDH19 gene are a relatively common cause of epilepsy. To better understand the basis of this disorder, we have developed unique mouse models that mimic the genetic changes and symptoms of this condition. We will perform careful analysis of brain development in these models to determine the primary cause of this condition. These experiments will create greater understanding of how changes in PCDH19 cause epilepsy in girls and facilitate the development of new treatments.
Evolutionary proteomics of social insects. This project aims to understand the molecular mechanisms that affect fertility in honeybees and leaf-cutting ants by identifying the function of proteins in male and female secretions related to insemination and sperm storage. The understanding of these general principles will have important applications for honeybee breeding.
Brain temperature regulation in mammals: mechanisms and consequences. Mammals detect increases in body temperature predominantly in the brain. Counterintuitively many mammals selectively cool the brain during heat stress, which appears to defeat the mechanism for inducing cooling responses. We intend to investigate this apparent anomaly which we believe is concerned with optimizing water use in hot conditions. We will further investigate the source of water for evaporative cooling by panting and ....Brain temperature regulation in mammals: mechanisms and consequences. Mammals detect increases in body temperature predominantly in the brain. Counterintuitively many mammals selectively cool the brain during heat stress, which appears to defeat the mechanism for inducing cooling responses. We intend to investigate this apparent anomaly which we believe is concerned with optimizing water use in hot conditions. We will further investigate the source of water for evaporative cooling by panting and discover if there has been convergent evolution in thermoregulatory strategies in the eutherian and marsupial lineages. The data we collect will be used to support a new model for thermoregulation in mammals.
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The comparative physiology of oxygen delivery to the kidney. The kidney is in danger of hyperoxia because the kidney receives so much blood relative to its mass. It is proposed that shunting oxygen between arteries and veins substantially mitigates the risk of hyperoxia, but under certain circumstances shunting substantially increases the risk of kidney hypoxia. Using a combination of synchrotron and histological imaging, This project will carefully define the three-dimensional vasculature of th ....The comparative physiology of oxygen delivery to the kidney. The kidney is in danger of hyperoxia because the kidney receives so much blood relative to its mass. It is proposed that shunting oxygen between arteries and veins substantially mitigates the risk of hyperoxia, but under certain circumstances shunting substantially increases the risk of kidney hypoxia. Using a combination of synchrotron and histological imaging, This project will carefully define the three-dimensional vasculature of the renal cortex in several different species and interpret its functional significance using computational modeling. The outcome of this project will be a new understanding in the comparative physiology of oxygen transport and shunting in the kidney.Read moreRead less
Evaporative water loss and relative water economy in marsupials. Marsupials are an iconic element of the Australian fauna, so the robust physiological database we will establish has intrinsic educational and scientific value to Australians. We will provide important methodological and analytical advances at the cutting edge of physiological research. This project will sustain our leading role as marsupial physiologists in the international scientific community, contribute to the high-quality tra ....Evaporative water loss and relative water economy in marsupials. Marsupials are an iconic element of the Australian fauna, so the robust physiological database we will establish has intrinsic educational and scientific value to Australians. We will provide important methodological and analytical advances at the cutting edge of physiological research. This project will sustain our leading role as marsupial physiologists in the international scientific community, contribute to the high-quality training of research students, foster national and international collaboration, and generally enhance the scientific profile of Australia. Knowledge of a species' biology and its interactions with the environment are essential for conservation in the face of landscape modification and climate change.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100188
Funder
Australian Research Council
Funding Amount
$550,000.00
Summary
Terabase sequencing for mutant, developmental, environmental and population genomics. This facility will make it possible to completely sequence the genome (and epi-genome and transcriptome) of a large number of samples in a cost effective manner. This will provide researchers with unprecedented ability to compare individuals in a population and to discover and define novel traits which govern disease resistance, yield and population dynamics in natural systems.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989782
Funder
Australian Research Council
Funding Amount
$524,000.00
Summary
A Core Western Australian Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations. This new generic capacity to rapidly isolate structures smaller than the cell has extraordinarily wide application in the biological sciences. Making this capacity widely accessible through a core facility to the Western Australian research community will generate research outcomes of national and community benefit. Sorting chromosomes to better understand genetic abnormalities and sorting bacteria t ....A Core Western Australian Cell Sorting Facility - Ultra-Small Objects and Rare Cell Populations. This new generic capacity to rapidly isolate structures smaller than the cell has extraordinarily wide application in the biological sciences. Making this capacity widely accessible through a core facility to the Western Australian research community will generate research outcomes of national and community benefit. Sorting chromosomes to better understand genetic abnormalities and sorting bacteria to better understand and reduce bacterial infection will result in improvements in human health. Sorting parasites, bacteria and immune cells will lead to new animal vaccines for parasites and diseases such as bird flu. Sorting marine plankton will lead to more sustainable marine ecosystems and fisheries.Read moreRead less
Calls and constraints: do male frogs signal direct benefits? There is international concern over recent declines and disappearances of many species of amphibians. Australia is a hotspot for declines, but causes of declines remain enigmatic. Approximately one quarter of Australia's 230 amphibian species breed in terrestrial situations, but processes such as salinity, wetland and urban developments and climate change are altering the hydrology of our landscape, and preventing the flood events nece ....Calls and constraints: do male frogs signal direct benefits? There is international concern over recent declines and disappearances of many species of amphibians. Australia is a hotspot for declines, but causes of declines remain enigmatic. Approximately one quarter of Australia's 230 amphibian species breed in terrestrial situations, but processes such as salinity, wetland and urban developments and climate change are altering the hydrology of our landscape, and preventing the flood events necessary for the completion of the lifecycle of many species. This research has important conservation implications because it examines the effects of variable moisture regimes on the physiology and reproductive behaviours of terrestrial breeding frogs.Read moreRead less
Control of crop-microbe symbiosis by new plant hormones. This project aims to discover how plants use hormone-like chemicals, called butenolides, to control symbiotic relationships with soil fungi. It will use multidisciplinary and collaborative techniques to establish how butenolide metabolism affects the diversity of fungal colonisation. Expected outcomes of this project include a deeper understanding of how plants regulate the competency of roots to host symbiotic fungi, and how this affects ....Control of crop-microbe symbiosis by new plant hormones. This project aims to discover how plants use hormone-like chemicals, called butenolides, to control symbiotic relationships with soil fungi. It will use multidisciplinary and collaborative techniques to establish how butenolide metabolism affects the diversity of fungal colonisation. Expected outcomes of this project include a deeper understanding of how plants regulate the competency of roots to host symbiotic fungi, and how this affects plant growth. As such, it will generate knowledge of how cereals such as barley could be modified to improve their nutrient use efficiency. Benefits of this project include the potential to reduce fertiliser inputs, thereby improving the competitiveness and environmental impact of Australian agriculture.Read moreRead less