Intervening In The Natural History Of Type 1 Diabetes: An Integrated Approach
Funder
National Health and Medical Research Council
Funding Amount
$9,466,000.00
Summary
This Program brings together four of Australia’s top type 1 diabetes clinical and lab-based research teams. The program has three intersecting themes. The first theme, pathogenesis, focuses on early life and understanding why type 1 diabetes develops. The second theme, prevention, seeks to identifying new drugs to stop the disease from occurring. The third theme, treatment, aims to improve therapies to replace the cells that are destroyed during the disease process.
Better Outcomes Through Innovations In Clinical Trials: From Personalised Medicine To Population Health
Funder
National Health and Medical Research Council
Funding Amount
$12,215,475.00
Summary
This program aims to develop better health care though advances in clinical trials research and better methods for integrating trial evidence. The team comprises clinician researchers and trialists, biostatisticians, health economists and collaborative networks of clinical investigators. It aims to tackle major health care questions in priority health areas, in cancer, cardiovascular disease, and diabetes, where advances will have substantial impact on reducing death and serious disability.
The exposure of infants to adverse events both before and after birth can cause death or permanent disability (eg cerebral palsy) for the infant. Our primary research objective is to minimize the impact and improve outcomes for infants exposed to adverse events before and/or after birth. We will use a multi-disciplinary approach that aims to understand the science and to develop new treatments, thereby representing true “bench to bedside” research.
Discovery And Translation Of Evidence For New Strategies To Combat Cardiovascular Diseases
Funder
National Health and Medical Research Council
Funding Amount
$17,802,750.00
Summary
The Program brings together clinicians, epidemiologists and statisticians in a unique endeavour combating heart attack and stroke as well as diabetes and kidney disease, all of which are closely related, through “hardening of the arteries”. The Program will provide fresh evidence on innovative strategies for treating and preventing these disorders, as well as strategies for translating them into more effective health policy and improved clinical practice.
ADVANCING THE EVIDENCE BASE FOR CARE AND POLICY IN PRIORITY HEALTH AREAS
Funder
National Health and Medical Research Council
Funding Amount
$11,195,727.00
Summary
This program will improve health care and policy through clinical trials research and better methods for combining trial evidence. The team will tackle priority health areas to reduce death and serious disability: in particular in cancer, cardiovascular disease, diabetes, obesity and neonatal diseases. The program team includes clinicians, epidemiologists, trialists, biostatisticians, and health economists and collaborative networks of clinical investigators in each disease area.
Creating Safe, Effective Systems Of Care: The Translational Challenge
Funder
National Health and Medical Research Council
Funding Amount
$10,855,710.00
Summary
There are considerable improvements to be made to the health system if we make a concerted effort to translate what we already know is effective into routine practice. This research will further our knowledge of how to translate evidence into practice more effectively and spread best practice throughout the health system.
We seek to understand how white blood cells detect and destroy disease, and how molecules of the immune system punch holes in diseased cells. We wish to learn how cancer can sometimes evade the immune system. Our work will also find out how some common treatments for cancer, like chemotherapy, can be used to boost the immune system and eliminate tumours. Through knowledge gained from these studies, we aim to develop new therapies that can help patients with devastating diseases like cancer.
Mental Health Of Young People With Developmental Disabilities
Funder
National Health and Medical Research Council
Funding Amount
$5,622,916.00
Summary
Mental health problems of people with developmental disabilities are a substantial public health problem. A large Australian study shows that the problem begins early and persists without intervention. We will evaluate the Stepping Stones Triple P model of parenting early intervention after adding newly developed modules for specific causes of ID. The effectiveness of the program across three states will be evaluated.