Preparing Australia For Genomic Medicine: A Proposal By The Australian Genomics Health Alliance
Funder
National Health and Medical Research Council
Funding Amount
$25,000,000.00
Summary
The sequencing of the human genome brings the possibility of more accurate identification of the underlying basis of many diseases. This technology has moved so rapidly, however, that clinical access has been limited. In this application, a national alliance of clinicians, researchers, health economists and policymakers will evaluate the case for clinical genomics across inherited disease and cancer, determine how best to deliver this to the patient and train a capable workforce.
Temperature sensitivity of soil respiration and its components. This project aims to demonstrate how temperate evergreen forests could buffer against climate change. Soil respiration returns around half the carbon taken up by forests to the atmosphere. This project will characterise and quantify how microbes and roots in soils depend on temperature and substrate supply, and so predict how rising temperatures and drought will affect forests as natural carbon sequestration sinks. This project will ....Temperature sensitivity of soil respiration and its components. This project aims to demonstrate how temperate evergreen forests could buffer against climate change. Soil respiration returns around half the carbon taken up by forests to the atmosphere. This project will characterise and quantify how microbes and roots in soils depend on temperature and substrate supply, and so predict how rising temperatures and drought will affect forests as natural carbon sequestration sinks. This project will resolve the roles of environmental drivers of soil respiration across forests; integrate mechanistic understanding of differing plant and microbial responses to temperature within a common modelling framework; and evaluate the implications of this knowledge in predictions of climatic impacts on terrestrial carbon cycling.Read moreRead less
Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The ser ....Development of new tools for surveillance of chlamydial infections in sheep. This project aims to improve health in sheep and reduce on-farm losses for Australian producers, by developing new serological tests for chlamydial infections in sheep. These infections can result in significant on-farm losses and loss of trade in the live export industry. Currently, surveillance of chlamydial infections is hindered by outdated serological tools that are unreliable and difficult to interpret. The serological tests to be developed aim to be species-specific tests to detect the most important chlamydial sheep pathogens. This in turn endeavours to improve domestic surveillance, reducing on-farm losses and costs, and improve market opportunities for Australian sheep exporters as well as informing veterinary populations on best practice treatment.Read moreRead less
Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size dis ....Linking phytoplankton to fisheries using zooplankton size spectra. This project aims to develop innovative numerical methods to understand the dynamics, carbon export, and trophic structure of zooplankton. The trophic links between phytoplankton, zooplankton and fisheries are unknown. The size- frequency distribution of zooplankton (size spectrum) is an innovative method for estimating their growth, predation and production as food for fish. Analysis of a global synthesis of zooplankton size distributions from tropical to polar environments are expected to reveal these vital rates of pelagic ecosystems. The zooplankton rates will reveal, for the first time, the link between phytoplankton and fisheries, and will significantly improve ecosystem models and global assessments of environmental change.Read moreRead less
Resolving the role of dryland flooding in the global carbon cycle. Aquatic sources of carbon dioxide and methane are globally significant, but unknown for flooded drylands. The aim of this project is to use an innovative combination of well-integrated methodologies to determine if flooded drylands release large amounts of carbon dioxide and methane. This project is significant because this release of carbon dioxide and methane has not previously been accounted for and may change the magnitude of ....Resolving the role of dryland flooding in the global carbon cycle. Aquatic sources of carbon dioxide and methane are globally significant, but unknown for flooded drylands. The aim of this project is to use an innovative combination of well-integrated methodologies to determine if flooded drylands release large amounts of carbon dioxide and methane. This project is significant because this release of carbon dioxide and methane has not previously been accounted for and may change the magnitude of the global terrestrial carbon dioxide sink and account of some of the planet’s missing sources of methane. The outcomes of this project will make a significant contribution to our understanding of the global carbon cycle and earth climate system, and inform future management of these systems.
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Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbi ....Mapping and Modelling the Ocean's Unseen Biodiversity. From the reef to the rainforest, Australia is famous for its unique biodiversity. Less well known is that Australia's coastline is predicted to be a global hotspot for biodiversity in marine microbes, the unseen life forces that maintain ocean health and productivity. This project aims to overcome historical technological and logistical hurdles by using cutting-edge sampling, genetic and modelling tools to provide the first models of microbial diversity patterns and organismal range in Australian marine systems. This is expected to be a crucial step for understanding the evolutionary and ecological processes that shape contemporary biodiversity.Read moreRead less
Marine urban development: how can ecology inform the design of multifunctional artificial structures? This project aims to experimentally manipulate the design of artificial structures to achieve multipurpose ecological objectives. Artificial structures such as buildings and roads have featured in terrestrial urban landscapes for many years, but have only more recently begun encroaching on aquatic environments. Most marine artificial structures lack the innovative design solutions required to mi ....Marine urban development: how can ecology inform the design of multifunctional artificial structures? This project aims to experimentally manipulate the design of artificial structures to achieve multipurpose ecological objectives. Artificial structures such as buildings and roads have featured in terrestrial urban landscapes for many years, but have only more recently begun encroaching on aquatic environments. Most marine artificial structures lack the innovative design solutions required to mitigate their ecological impacts and provide essential ecosystem services such as pollution abatement. This project will investigate the efficacy of these designs with both classical measures of diversity and structure and novel measures of ecosystem function. The project aims to provide essential information to inform the design of future marine urban developments.Read moreRead less
Mechanisms And Therapies In Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$8,360,700.00
Summary
Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting ....Cardiovascular disease (CVD) claims 1 person every 10 min in Australia and causes 1 in 3 deaths worldwide. The molecular and cellular processes underlying atherosclerosis, vascular injury and thrombosis are highly complex and not well understood. A multifaceted approach is needed to effectively address these key challenges. This Program brings together world experts in these areas to interrogate gaps in our basic understanding of CVD, and to develop novel therapies for CVD patients by exploiting new knowledge through integrated research.Read moreRead less
Estimating And Alleviating The Impacts Of Age-Related Sensory Decline
Funder
National Health and Medical Research Council
Funding Amount
$323,767.00
Summary
Sensory loss and dementia disproportionately affect older adults, often co-occur, and are the two leading contributors to disability burden among older Australians. This research will investigate the consequences that hearing and vision loss have for older adult health and wellbeing, informing strategies to reduce the disability burden of age-related sensory loss. These impacts include cognitive decline and dementia, mental health, quality of life, disability and independent living.
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.