Improved electrophysiological mapping techniques have enhanced understanding of arrhythmia mechanisms and the development of curative ablation strategies. Advanced mapping systems utilize online visualization of catheters, 3D geometry, and annotation of ablation sites. To date, all commercially available systems rely on proprietary equipment to locate catheter positions and reconstruct chamber shape from multiple site recordings. Thus, cost is prohibitive, limiting widespread availability. An al ....Improved electrophysiological mapping techniques have enhanced understanding of arrhythmia mechanisms and the development of curative ablation strategies. Advanced mapping systems utilize online visualization of catheters, 3D geometry, and annotation of ablation sites. To date, all commercially available systems rely on proprietary equipment to locate catheter positions and reconstruct chamber shape from multiple site recordings. Thus, cost is prohibitive, limiting widespread availability. An alternative approach has emerged with the use of CT-MRI imaging and analysis. Novel techniques extract images of the endocardial surface from CT-MRI for use in electrophysiological mapping. This surface can be used as the chamber geometry instead of reconstruction based on expensive technology measuring spatial coordinates of the catheter tip inside heart. The proposed Anatomical Template Mapping System (ATMS) will generate maps of electrophysiological parameters derived from catheter recordings without the need for proprietary equipment. The physician will direct the virtual catheter position onto the 3D model of the chamber, obviating the need for equipment to map the spatial distribution of the catheters. The major advantage is that, without the need for specialized equipment, this method of mapping is substantially cheaper and can be used with any conventional electrophysiological mapping systems. Furthermore, it will provide the most important feature of the advanced mapping systems - an understanding of the arrhythmia mechanism.Read moreRead less
Development Of A Novel Biosensor Using Magnetically Amplified Luminescence For The Early Detection Of Cancer
Funder
National Health and Medical Research Council
Funding Amount
$267,500.00
Summary
Cancer is often not detected until it has invaded surrounding tissues and spread to other organs. Current treatment is then often ineffective, and prognosis poor. Early detection of cancer is therefore essential for improved disease management. Such methods must be cheap, non-invasive, and rapid with high sensitivity and specificity. We are investigating a new biosensor technology that satisfies these criteria. This method uses magnetically amplified luminescence for the detection of low levels ....Cancer is often not detected until it has invaded surrounding tissues and spread to other organs. Current treatment is then often ineffective, and prognosis poor. Early detection of cancer is therefore essential for improved disease management. Such methods must be cheap, non-invasive, and rapid with high sensitivity and specificity. We are investigating a new biosensor technology that satisfies these criteria. This method uses magnetically amplified luminescence for the detection of low levels of cancer cells in clinical samples (urine, faeces, blood, biopsy), using telomerase as a marker.Read moreRead less
Impact and Effectiveness of Personal Ventilation in Open Plan Offices: a study of the Task Air system. Centralised air-conditioning systems are the standard for commercial office buildings in Australia. These systems are energy intensive, typically accounting for around 50% of building energy use. However, lack of occupant control over set temperatures or air movement tends to reduce thermal comfort, which can adversely affect worker productivity. The benefit of this project is that it will qu ....Impact and Effectiveness of Personal Ventilation in Open Plan Offices: a study of the Task Air system. Centralised air-conditioning systems are the standard for commercial office buildings in Australia. These systems are energy intensive, typically accounting for around 50% of building energy use. However, lack of occupant control over set temperatures or air movement tends to reduce thermal comfort, which can adversely affect worker productivity. The benefit of this project is that it will quantify the improvements to occupant comfort and energy savings possible with a PV system. This study will enable PV systems to be evaluated as an alternative to traditional air-conditioning, thereby demonstrating their effectiveness as a means of improving the sustainability rating of commercial office buildings in Australia.Read moreRead less
The Characterisation of Fires in Tunnels. A series of 22 fires ranging from 2 megawatt up to 20 megawatt intensity will be set under controlled conditions in unused tunnel facilities, in New South Wales. Instrumentation in the tunnel, donated by the State Rail Authority of New South Wales, will monitor the movement of particulates (smoke). This information is vital to tunnel design, and for passenger life safety. This information will be applicable to all tunnels worldwide.
Consumer Information Materials And A Communication Aid For Diagnostic Tests For Breast Disease
Funder
National Health and Medical Research Council
Funding Amount
$105,863.00
Summary
Many studies have now shown that the majority of patients want to participate in clinical decisions about medical treatments they might receive. As a result, information materials are being developed to help consumers and doctors work together to reach satisfying treatment decisions which are based on the best available evidence and also reflect the individual patient's needs and preferences about the treatment options. Very little is known, however, about whether consumers also want to particip ....Many studies have now shown that the majority of patients want to participate in clinical decisions about medical treatments they might receive. As a result, information materials are being developed to help consumers and doctors work together to reach satisfying treatment decisions which are based on the best available evidence and also reflect the individual patient's needs and preferences about the treatment options. Very little is known, however, about whether consumers also want to participate in decisions about whether to have a medical test. Tests can be trivial, such as a blood or urine test, or quite major and invasive, such as a biopsy or a colonoscopy. People considering a medical test might want to know the answers to the following questions: What is my chance of having the disease being tested for? If the test result is positive what is the chance I have the disease? If the test result is negative what is the chance I have the disease anyway? How will the test result influence treatment of my condition? What are possible side-effects of the test? Generally information materials about medical tests only describe the test itself, and do not contain the information people need to answer these questions. Even doctors may not have to hand the data needed to answer these questions. Yet without this information, consumers cannot make truly informed and rational choices about whether to have the test. This project aims to find out whether consumers want to participate in decisions about medical tests, what information they would want to do this, and to develop and trial information materials and a communication aid for a small number of breast cancer tests. We will use tests for diagnosing breast cancer as our model but we anticipate the work will be applicable across a wide range of medical tests.Read moreRead less
Loop-mediated Isothermal Amplification(LAMP): A Novel Tool For The Diagnosis Of Mixed Malaria Infections In Elimination Settings
Funder
National Health and Medical Research Council
Funding Amount
$101,877.00
Summary
The malaria elimination agenda will require the development of novel, field applicable diagnostic tools to detect asymptomatic carriers of P.falciparum and non-falciparum malaria infections. Loop-mediated isothermal amplification (LAMP) has been demonstrated to be a novel, sensitive, specific nucleic acid amplification technique. My project aims to optimise LAMP into a high-throughput field applicable molecular diagnostic tool capable of diagnosing malaria in elimination settings
Development of a Compartment Fire Behaviour Training (CFBT) Database. In recent years, incidents of fire flashover have caused considerable destruction to property and the loss of life. Fire prediction and understanding is an area of significance to both the Australian public and the firefighting profession. The NSW Fire Brigade has recently introduced Compartment Fire Behaviour Training (CFBT). To extend this scheme, a database of configurations will be developed using computational modelling, ....Development of a Compartment Fire Behaviour Training (CFBT) Database. In recent years, incidents of fire flashover have caused considerable destruction to property and the loss of life. Fire prediction and understanding is an area of significance to both the Australian public and the firefighting profession. The NSW Fire Brigade has recently introduced Compartment Fire Behaviour Training (CFBT). To extend this scheme, a database of configurations will be developed using computational modelling, allowing firefighters the ability to experience virtually different situations. Detailed experimental studies will be conducted to validate the numerical model. This database will have use and significance beyond Australia and successful implementation promises reductions in the loss of life and property.Read moreRead less
Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will signific ....Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will significantly benefit the mineral exploration industry as well as underwater detection of cables and ship wrecks.Read moreRead less
Experimental and numerical study of sprinklers for improved fire safety. Fire sprinklers are a common method for extinguishing fires. Current lack of detailed knowledge about sprinklers can lead to conservative design and excessive cost, often limiting the installation of these proven life-saving devices. This project sees the involvement of Arup Pty Ltd and the NSW Fire Brigade in examining the behaviour of sprinklers using a custom-designed test-rig, laser based measurement and a numerical mod ....Experimental and numerical study of sprinklers for improved fire safety. Fire sprinklers are a common method for extinguishing fires. Current lack of detailed knowledge about sprinklers can lead to conservative design and excessive cost, often limiting the installation of these proven life-saving devices. This project sees the involvement of Arup Pty Ltd and the NSW Fire Brigade in examining the behaviour of sprinklers using a custom-designed test-rig, laser based measurement and a numerical model. This will result in improved confidence in sprinkler specification and installation and the project will have use and significance beyond Australia. Successful implementation promises reductions in the loss of life and property as well as financial savings.Read moreRead less
Promotion Of Self-help Strategies For Sub-threshold Depression Via The Internet: Randomised Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$91,573.00
Summary
Depressive symptoms are common, impair individual functioning, and may develop into a full depressive disorder. Self-help for depressive symptoms is well-liked and often used, but some strategies are not as effective as others. This project will test the feasibility of promoting helpful self-help strategies to those with a high level of depressive symptoms, using the internet. The aim is to reduce the overall level of depressive symptoms and the number developing a full depressive disorder.