Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0452281
Funder
Australian Research Council
Funding Amount
$102,900.00
Summary
Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessmen ....Muscle Vascular Research and Gene Therapy Using Ultrasound. We seek funds to set up a national facility for ultrasound in muscle vascular research and gene therapy. Ultrasound with microbubbles will be used for the imaging of muscle microvascular blood flow and as a delivery modality for gene constructs to endothelial cells that control blood flow. The technology has application to (i) the assessment and therapeutic treatment of impaired microvascular function as in diabetics; (ii) the assessment of adaptation to physical training and (iii) the development of therapeutic agents used to treat diabetes. We anticipate improved technology that is fully characterized and novel therapeutics that improve microvascular blood flow.Read moreRead less
Aboriginal patch burning and the quest for sustainable fire management. This project aims to document historical changes in the spatial grain of the patch burning mosaic in an Arnhem Land savannah with an unbroken history of management by Aboriginal people, and in adjacent areas where traditional management has ceased. The mosaic's spatial grain will be inferred by mapping the individual ages of the long-lived conifer Callitris intratropica. Prior research has shown that Callitris individuals c ....Aboriginal patch burning and the quest for sustainable fire management. This project aims to document historical changes in the spatial grain of the patch burning mosaic in an Arnhem Land savannah with an unbroken history of management by Aboriginal people, and in adjacent areas where traditional management has ceased. The mosaic's spatial grain will be inferred by mapping the individual ages of the long-lived conifer Callitris intratropica. Prior research has shown that Callitris individuals can be reliably aged, and population structures are very sensitive to fire regimes: saplings only establish if unburnt for 10 years. This research is expected to provide the first direct test of the hypothesis that Aboriginal people maintained fine-grained fire mosaics in savannas, and inform bushfire policy debates.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
Devising ecologically sustainable restoration programs for degraded rural landscapes by integrating landscape ecology, genetics and ecophysiology. Concern about tree decline in rural landscape is widespread, and disturbingly climate change is predicted to exacerbate this problem. Past ill-considered tree plantings have proven to be economically wasteful, achieved limited ecological resilience and negligible improvement of biodiversity values. Using Tasmania as a 'model system', we will advance t ....Devising ecologically sustainable restoration programs for degraded rural landscapes by integrating landscape ecology, genetics and ecophysiology. Concern about tree decline in rural landscape is widespread, and disturbingly climate change is predicted to exacerbate this problem. Past ill-considered tree plantings have proven to be economically wasteful, achieved limited ecological resilience and negligible improvement of biodiversity values. Using Tasmania as a 'model system', we will advance this problem by undertaking research to determine how seedling establishment, tree growth, carbon storage and water use are influenced by landscape setting, management history, climate change, species type and local varieties. This research will provide a much needed evidence to devise ecologically sustainable tree-plantings in southern Australia.Read moreRead less
Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE170100219
Funder
Australian Research Council
Funding Amount
$170,000.00
Summary
A multi-institutional environmental radioactivity research centre. This project aims to establish an environmental radioactivity research centre, equipped with ultra-low background and high-resolution alpha and gamma spectrometry systems, radon detectors and radium delayed coincidence counters. The centre will address a critical demand in Australia for precise analysis of a large suite of natural and artificial radionuclides, which will be used as tracers and chronological tools to investigate k ....A multi-institutional environmental radioactivity research centre. This project aims to establish an environmental radioactivity research centre, equipped with ultra-low background and high-resolution alpha and gamma spectrometry systems, radon detectors and radium delayed coincidence counters. The centre will address a critical demand in Australia for precise analysis of a large suite of natural and artificial radionuclides, which will be used as tracers and chronological tools to investigate key questions in oceanography and the mining and energy, archaeological, agricultural, and forestry sectors. The facility is expected to substantially increase expertise and training in radionuclides in Australia, and promote high-level research collaborations and outputs of both national and international significance. Major outcomes of the proposed facility include better understanding of how oceans regulate climate and improved capacity to assess effects of radiation on natural ecosystems.Read moreRead less
Defining winning strategies in a changing Southern Ocean . The ecosystem of the Southern Ocean is extremely complex, and understanding its response to rapid climate change is challenging. The aim of the project is to use changes in the behaviour of marine predators to provide new measures of integrated changes in eastern Antarctic ecosystems throughout the winter. With novel combinations of electronic tagging, natural biogeochemical markers, and simulation modelling, the project expects to recon ....Defining winning strategies in a changing Southern Ocean . The ecosystem of the Southern Ocean is extremely complex, and understanding its response to rapid climate change is challenging. The aim of the project is to use changes in the behaviour of marine predators to provide new measures of integrated changes in eastern Antarctic ecosystems throughout the winter. With novel combinations of electronic tagging, natural biogeochemical markers, and simulation modelling, the project expects to reconstruct changes in animal behaviour in response to changes in the environment. The data is anticipated to explain ongoing large-scale shifts in Southern Ocean ecosystems, providing information needed to underpin future management and adaptation strategies.Read moreRead less