Magnetofluidic sample handling for enhanced point-of-care diagnosis. This project aims to decipher the mechanism behind recent discovery on the enhancement of mixing and separation with magnetism and to apply it to the rapid and early detection of malaria and cancer. This mechanism provides novel and unique fluid handling capabilities, which allow the development of revolutionary point-of-care diagnostic approaches that integrate magnetic mixing, separation and detection on a single device. The ....Magnetofluidic sample handling for enhanced point-of-care diagnosis. This project aims to decipher the mechanism behind recent discovery on the enhancement of mixing and separation with magnetism and to apply it to the rapid and early detection of malaria and cancer. This mechanism provides novel and unique fluid handling capabilities, which allow the development of revolutionary point-of-care diagnostic approaches that integrate magnetic mixing, separation and detection on a single device. The outcomes of this project are instrumental for the reduction of healthcare cost, promoting good health for Australian and potentially creating new jobs in the niche biomedical industry.Read moreRead less
Functional state observers for large-scale interconnected systems. This project will produce conceptual advances with new design rules to develop robust and efficient functional state observers for interconnected systems. The outcomes will advance the theory of functional observers and improve the operation, efficiency and performance of critical infrastructure such as power grids, water and traffic networks.
Complex Multiscale Systems: Modeling, Analysis and Scientific Computation. This project aims to develop and implement a systematic approach, both analytic and computational, to extract compact, accurate, system level models of complex physical and engineering systems. The wide ranging methodology is to construct computationally efficient "wrappers" around fine scale, microscopic, detailed descriptions of dynamical systems (particle or molecular simulation, or partial differential equations or la ....Complex Multiscale Systems: Modeling, Analysis and Scientific Computation. This project aims to develop and implement a systematic approach, both analytic and computational, to extract compact, accurate, system level models of complex physical and engineering systems. The wide ranging methodology is to construct computationally efficient "wrappers" around fine scale, microscopic, detailed descriptions of dynamical systems (particle or molecular simulation, or partial differential equations or lattice equations). Comprehensively accounting for multiscale interactions between subgrid processes among macroscale variations ensures stability and accuracy. Based on dynamical systems theory and analysis, this approach is expected to empower systematic analysis and understanding for optimal macroscopic simulation for forthcoming exascale computing.Read moreRead less
Atomic Resolution Sensors for Imaging and Metrological Science. This project aims to create new sensing technologies for detecting motion on the atomic scale with Megahertz (MHz) bandwidth. Advanced signal processing and communication theory will be applied with the aim of developing new classes of capacitive, inductive and optical position sensors. The resolution and bandwidth are predicted to be a one-hundred fold improvement over the current state-of-the-art. Applications are expected to incl ....Atomic Resolution Sensors for Imaging and Metrological Science. This project aims to create new sensing technologies for detecting motion on the atomic scale with Megahertz (MHz) bandwidth. Advanced signal processing and communication theory will be applied with the aim of developing new classes of capacitive, inductive and optical position sensors. The resolution and bandwidth are predicted to be a one-hundred fold improvement over the current state-of-the-art. Applications are expected to include biomedical imaging, high-speed nanofabrication, high-resolution computer numerical control (CNC) machining, high-speed gas and chemical sensors, and ultra-precise seismometers and gyroscopes.Read moreRead less
Accurate modelling of large multiscale dynamical systems for engineering and scientific simulation and analysis. In current modelling the underlying microscopic mechanisms are known, but the closures to translate microscale knowledge to a system level macroscopic description are rarely available. The project's computational methodologies will circumvent this stumbling block to radically change the modelling, exploration and understanding of complex systems.
Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cos ....Nanoarchitectured multifunctional porous superparamagnetic nanoparticles. This project aims to develop a method for the direct detection of biomarkers based on a new class of highly porous superparamagnetic nanoparticles with peroxidase-like activity. The particles will be used as dispersible capture agents for isolating specific targets in biological samples, and electrocatalytic nanozymes for naked-eye evaluation and electrochemical detection. The project is expected to develop simple, low-cost, portable devices for the analysis of exosomes and exosomal miRNA in biological samples. The future development of this technology into diagnostic devices will improve patient outcomes by enabling earlier disease diagnosis and improved monitoring of treatment.Read moreRead less
Individually addressable, active, multipoint electrodes for bio-potential recording and electrical impedance imaging. We will develop non-invasive devices based on biosignal and impedance monitoring. They will be highly portable and based on comfortable electrode patches that can be applied quickly in emergencies. The technology may be used to save lives and reduce disabilities by monitoring strokes and heart attacks and stimulate Australia's biomedical industry.
Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and d ....Microcantilevers for multifrequency atomic force microscopy. This project aims to design a microcantilever with high-performing sensors more sensitive and with better noise performance than the typical optical system used in commercial Atomic Force Microscopes (AFMs). The AFM, a nanotechnology instrument, uses a microcantilever (with an extremely shape probe) to interrogate a sample surface. It has made important discoveries in nanotechnology, life sciences, nanomachining, material science and data storage systems. Despite its success, the technique’s spatial resolution and quantitative measurements are limited. This project could lead to breakthrough technologies such as atomic force spectroscopy to study elastic modulus of nanostructures, and establish Australia's prominence in this emerging field.Read moreRead less
Multiscale modelling of systems with complex microscale detail. In modern science and engineering many complex systems are described by distinctly different microscale physical models within different regions of space. This project is to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling and computation of such systems for application in industrial research and development. Our sparse simulations, justified with mathematical analysis, use ....Multiscale modelling of systems with complex microscale detail. In modern science and engineering many complex systems are described by distinctly different microscale physical models within different regions of space. This project is to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling and computation of such systems for application in industrial research and development. Our sparse simulations, justified with mathematical analysis, use small bursts of particle/agent simulations, PDEs, or difference equations, to efficiently evaluate macroscale system-level behaviour. The objective is to accurately interface between disparate microscale models and establish provable predictions on how the microscale parameter spaces resolve at the macroscale.Read moreRead less
Multiscale modelling of systems with complex microscale detail. This project aims to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling of systems with microscopic irregular details. The methodology, justified with mathematical analysis and computation, uses small bursts of particle/agent simulations, partial differential equation (PDEs), or difference equations, to efficiently predict macroscale behaviour. This project’s mathematical meth ....Multiscale modelling of systems with complex microscale detail. This project aims to develop systematic mathematical and computational methods for the compact and accurate macroscale modelling of systems with microscopic irregular details. The methodology, justified with mathematical analysis and computation, uses small bursts of particle/agent simulations, partial differential equation (PDEs), or difference equations, to efficiently predict macroscale behaviour. This project’s mathematical methodology aims to efficiently and accurately extract and simulate the collective dynamics which emerge on macroscales, leading to improved prediction and understanding of the significant features of these complex systems at the scale relevant to engineers and scientists.Read moreRead less