Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic erro ....Predicting the diagnostic performance of individuals and organisations. Predicting the diagnostic performance of individuals and organisations. This project aims to address diagnostic error in advanced technology systems, by providing a mechanism to assess and improve individual diagnosticians’ performance. Organisations that rely on their employees’ diagnostic skills rarely assess them once the operators become qualified, so there is no basis for interventions that might prevent diagnostic errors affecting thousands. This research tests a new method of assessing diagnostic skills based on how skilled operators respond to cues. This project will test how employees’ diagnostic skills change and whether this change corresponds to measures of organisational performance. This research is expected to provide organisations with a tool to pre-empt diagnostic errors that could minimise costs to the economy.Read moreRead less
In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually as ....In-line SPE-CE for the direct determination of drugs and metabolites in biological fluids based on porous polymer monoliths. A new approach is proposed for the development of novel micro- and nano-scale solid-phase adsorbent materials. These materials are based on porous polymer monoliths formed in situ within a capillary acting as a mould. The allows the material to be readily placed in a defined position, in a process similar to photo-patterning, and alleviates many of the problems usually associated with fabrication and miniaturisation. A simple photo-grafting process, initiated by UV light can be used for the selective chemical modification of these materials. These tailored monoliths can then be used for the in-line coupling of biological sample handling and capillary electrophoresis (CE) for the determination of drugs and related metabolites in biological fluids, thus avoiding time-consuming and costly off-line sample pre-treatment. This will lead to the development of new methods for the rapid determination of drugs, metabolites and other small molecules in clinical samples.Read moreRead less
Ensuring The Utility And Sustainability Of Tissue Banks: Supporting Translational Research In Australia Through Informed Regulation And Community Engagement.
Funder
National Health and Medical Research Council
Funding Amount
$481,885.00
Summary
Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulati ....Tissue banks provide a critical resource for translational research into the causes and treatment of many diseases affecting children and adults, such as cancer.Their success and contribution to medical research depends on addressing the many unresolved and emerging challenges that impact their work. This is the first national empirical study engaging the Australian research community, legal experts tissue donors and the public about the challenges to tissue banks to inform ethico legal regulation and deliver better health care systems.Read moreRead less
Uncovering the genetic basis for saxitoxin production in Australian marine and freshwater systems: novel molecular tools for management. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will use an innovative method to design a molecular genetic tool to monitor, research and potentially mitigate the effects of saxitoxin production on water supplies and aquaculture industries. In working ....Uncovering the genetic basis for saxitoxin production in Australian marine and freshwater systems: novel molecular tools for management. In Australia, toxic algal blooms have had a devastating impact on marine and freshwater resources. In collaboration with a biotechnology company, this project will use an innovative method to design a molecular genetic tool to monitor, research and potentially mitigate the effects of saxitoxin production on water supplies and aquaculture industries. In working with monitoring authorities throughout Australia, we will produce a specific, sensitive and cost-effective technology that will ultimately be applicable worldwide. Read moreRead less
Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug develo ....Bioanalytical Microchips Based on Integrated, Application Tailored Monolithic Modules. Microfluidic devices offer substantial advantages over current technology, in terms of speed, cost of analysis, portability, operator simplicity and safety. Integrating multiple analytical processes within a simple and reliable portable device will lead to application in a range of areas, from pharmacology to therapeutic drug monitoring, proteomic and metabolomic screening for disease diagnosis and drug development, and also for performing clinical diagnostics in a rural area. This will significantly impact on the quality of life of the Nation as a whole, not only due to expedient diagnosis and treatment which has obvious health benefits, but also in the considerable financial benefits that result from early and efficient treatment. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH150100028
Funder
Australian Research Council
Funding Amount
$3,708,510.00
Summary
ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecu ....ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. ARC Research Hub for Integrated Device for End-user Analysis at Low-levels. This hub aims to improve detection of biological materials by building a portable device for rapid, time-critical detection of low-abundance molecular and cellular analytes. It is expected that the resulting technologies would be used at medical points of care, ordinary workplaces and centres of activity to test for tiny levels of targeted molecules. The initial focus would be early diagnosis of disease and point-of-care drug testing for humans and animals, but the technology platform could be used to sample food and environmental toxins. The hub expects these disruptive technologies will make Australian biotechnology, diagnostics, veterinary, agribusiness and manufacturing firms globally competitive.Read moreRead less
The Salmon Ponds and the Development of an Acclimatisation Culture and Landscape in the Derwent Valley, Tasmania. The Derwent Valley, Tasmania, is both an economically depressed rural area and one of the most special and richly endowed colonial landscapes. This project will assist in developing and restoring its status as a touring and angling landscape for tourists by researching and reconstructing its making through the acclimatisation network centred on its cultural and technical hub at Salm ....The Salmon Ponds and the Development of an Acclimatisation Culture and Landscape in the Derwent Valley, Tasmania. The Derwent Valley, Tasmania, is both an economically depressed rural area and one of the most special and richly endowed colonial landscapes. This project will assist in developing and restoring its status as a touring and angling landscape for tourists by researching and reconstructing its making through the acclimatisation network centred on its cultural and technical hub at Salmon Ponds, New Norfolk. The research will trace the social and technical networks that linked newly formed angling associations,landowners, technical and scientific expertise with commercial and political patronage. It will elaborate how these in turn produced both a unique landscape and a culturally embedded association with it.Read moreRead less
Museum of New and Old Art (MONA) and the social and cultural coordinates of urban regeneration through arts tourism. This project will analyse the extraordinary success of MONA (Museum of New and Old Art) as an art gallery and use this information to identify, stimulate and sustain innovative collaborations between MONA, the cities of Hobart and Glenorchy, and the state of Tasmania, aimed at maximising visitor numbers to the state from art related tourism.
Transforming Tourists' Antarctic Experience. With the Antarctic tourist industry currently growing and diversifying, the project aims to discover how cruise operators can foster positive and culturally informed relationships with the region among visitors of different national backgrounds. Through extensive in-situ fieldwork with partner Intrepid Travel, the project expects to generate new understandings of how operators' active mediating role combines with multisensory experience of Antarctica ....Transforming Tourists' Antarctic Experience. With the Antarctic tourist industry currently growing and diversifying, the project aims to discover how cruise operators can foster positive and culturally informed relationships with the region among visitors of different national backgrounds. Through extensive in-situ fieldwork with partner Intrepid Travel, the project expects to generate new understandings of how operators' active mediating role combines with multisensory experience of Antarctica to forge human connections with this extreme but fragile place. Anticipated outcomes include protocols for best practice in designing and implementing tourist experiences. By encouraging diverse visitors to value Antarctica, the project should benefit both operators and the polar environment.Read moreRead less
The Silent Buildings of Willow Court: testing a new and innovative model for cultural heritage assessment. This pilot project is fuelled by an urgent need to assess the resources of the historic Willow Court Precinct, Australia's longest serving mental health facility (1827-2000). The 18-hectare Precinct, with its now abandoned buildings, is located in one of Australia's most economically deprived regions, Tasmania's Derwent River Valley. In June 2002 the Precinct was acquired by the local Counc ....The Silent Buildings of Willow Court: testing a new and innovative model for cultural heritage assessment. This pilot project is fuelled by an urgent need to assess the resources of the historic Willow Court Precinct, Australia's longest serving mental health facility (1827-2000). The 18-hectare Precinct, with its now abandoned buildings, is located in one of Australia's most economically deprived regions, Tasmania's Derwent River Valley. In June 2002 the Precinct was acquired by the local Council. At the same time, a theoretical model for measuring the condition and pressures on historic sites was being developed by the state government's Cultural Heritage Advisory Group. This project will use the Willow Court Precinct to test the model.Read moreRead less