Rapid, Point Of Care Diagnostic Tests To Differentiate HA Subtypes In Patients Samples
Funder
National Health and Medical Research Council
Funding Amount
$168,293.00
Summary
A number of rapid, point-of-care tests are available for the detection of human and avian influenza types, but they vary greatly in sensitivity. In particular, these tests are based on current strains of H5 (avian) influenza, and may be unable to detect variant or pandemic strains, and negative results can give the false impression that patients do not have H5 influenza. We will develop rapid, point-of-care tests based on highly conserved parts of the virus, so that all H5 strains (current and f ....A number of rapid, point-of-care tests are available for the detection of human and avian influenza types, but they vary greatly in sensitivity. In particular, these tests are based on current strains of H5 (avian) influenza, and may be unable to detect variant or pandemic strains, and negative results can give the false impression that patients do not have H5 influenza. We will develop rapid, point-of-care tests based on highly conserved parts of the virus, so that all H5 strains (current and future) can be detected with equal sensitivity, along with the H1 and H3 strains that are currently found in man to provide a definitive diagnosis. These tests will be valuable in the identification and differentiation of pandemic influenza cases, allowing better use of public health resources, especially against a background of continuing standard (H1 and H3) influenza infections.Read moreRead less
In Vitro Diagnostic For First Trimester Risk Assignment Of Gestational Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$580,983.00
Summary
Pregnancy associated diabetes is a significant complication of pregnancy that has adverse health effects for both mother and baby. We have developed a multivariate algorithm to identify women during their first trimester of pregnancy who will subsequently develop gestational diabetes. The test requires further clinical validation to develop a commercial product and to implement it into clinical practice.
Repeat Expansions In Neurological Disease: Discovery, Interpretation And Enhanced Diagnostics
Funder
National Health and Medical Research Council
Funding Amount
$889,937.00
Summary
Identifying the mutation or genetic cause of disease in an individual is the first step in the provision of appropriate clinical care and treatment. This diagnostic process is being revolutionised through the ability to sequence the entire human genome in a time and cost effective manner. This project will enable identification of novel and known repeat expansion using whole genome sequencing, providing rapid diagnoses and better clinical care for individuals with neurogenetic disorders.
Evaluation Of Blood-based Screening Tests For Colorectal Neoplasia; From Biomarker Candidates To Accurate And Acceptable Tests
Funder
National Health and Medical Research Council
Funding Amount
$767,382.00
Summary
Current bowel cancer screening tests require people to collect a stool sample. While able to be done at home, this creates certain inconveniences and has other barriers to its use including being distasteful to some. Also, even though stool tests are useful they are not as accurate as we would like. We have discovered a molecule in the blood of patients with bowel cancer that could, if configured as a screening test, serve to be of even greater accuracy and also be more acceptable to people.
Development Of A Glucose-6-phosphate Dehydrogenase/ Haemoglobin Point-of-care Test For Malaria Elimination
Funder
National Health and Medical Research Council
Funding Amount
$560,608.00
Summary
Malaria elimination requires the use of specific anti-malarial drugs that treat the dormant malaria parasites in the liver. The use of these drugs in people with a deficiency of the glucose-6-phosphate dehydrogenase (G6PD) enzyme can lead to the catastrophic destruction of red blood cells and severe anaemia. There is a need for new G6PD diagnostic tests that can be delivered in remote, resource poor settings. This project will develop a G6PD point-of-care test to fast-track malaria elimination.
Comprehensive Clinical Tests Of Vestibular Function To Track Vestibular Compensation And Meniere’s Disease
Funder
National Health and Medical Research Council
Funding Amount
$390,625.00
Summary
This Project will apply new, fast, safe, comprehensive, balance tests we have developed to measure the function of the balance receptors of the inner ear. We will track changes in balance function during disease and recovery in the many, and increasing, number of Australian patients with balance disorders. These tests will give us insight into changes in the inner ear associated with severe attacks of vertigo and why some patients recover so poorly after damage to inner ear balance receptors.
Delivering Precision Diagnosis To Patients With Mitochondrial Disease: Using Digital Technologies To Enhance The Delivery Pathway To Provide An Accurate Genetic Diagnosis For Patients With Mitochondrial Disease
Funder
National Health and Medical Research Council
Funding Amount
$1,273,553.00
Summary
Mitochondrial disease (MD) is the most common inherited metabolic condition. MD can be diagnosed by using whole genome sequencing (WGS) and enables treatment and accurate family planning. We will create a web-base platform to support the diagnosis and treatment of patients with or suspected to have MD. Using a custom-built web-based platform, telemedicine and automated software we will integrate care by primary care givers and MD experts to deliver a precise genetic diagnosis to our MD patients.
The proposal builds on innovative technologies patented and published by my group. The project has two specific objectives: 1) to deliver the new generation of intelligent biomedical devices that have the capacity to control infections, inflammation and foreign body response; and 2) to develop a novel, non-invasive and affordable point of care diagnostic technology for early detection of chronic kidney diseases, and kidney and bladder cancers that is much needed in this space of healthcare.
Skin Patch Technology For Fast And Simple Monitoring Of Disease
Funder
National Health and Medical Research Council
Funding Amount
$826,064.00
Summary
Micropatch kits will be developed to capture and detect disease-related biomarkers from the skin for diagnostic monitoring, without the need for needles, trained practitioners or expensive laboratory infrastructure
Prediction Of Response To Neoadjuvant Breast Cancer Therapy By Magnetic Resonance Imaging (MRI)
Funder
National Health and Medical Research Council
Funding Amount
$67,321.00
Summary
Neoadjuvant chemotherapy (NAC) has a well-established role in the management of breast cancer. Various roles have been proposed for magnetic resonance imaging (MRI) in the NAC setting, including its application in prediction of final pathologic response when undertaken early during a planned NAC course; the detection of residual disease after completion of NAC; and the measurement of residual tumour extent. The present study aims to determine the accuracy of MRI (relative to other imaging and cl ....Neoadjuvant chemotherapy (NAC) has a well-established role in the management of breast cancer. Various roles have been proposed for magnetic resonance imaging (MRI) in the NAC setting, including its application in prediction of final pathologic response when undertaken early during a planned NAC course; the detection of residual disease after completion of NAC; and the measurement of residual tumour extent. The present study aims to determine the accuracy of MRI (relative to other imaging and clinical tests) in these clinical scenarios.Read moreRead less