Single spin molecular microscope. This project aims to create a new tool for imaging and analysing material at the atomic level. The tool is based on individual quantum coherent spins in diamond which can be manipulated and optically read. The project expects to generate knowledge in quantum metrology and an understanding of molecular dynamics at the nanoscale. The expected outcome is a new type of device capable of imaging complex physical systems at the level of their individual constituent co ....Single spin molecular microscope. This project aims to create a new tool for imaging and analysing material at the atomic level. The tool is based on individual quantum coherent spins in diamond which can be manipulated and optically read. The project expects to generate knowledge in quantum metrology and an understanding of molecular dynamics at the nanoscale. The expected outcome is a new type of device capable of imaging complex physical systems at the level of their individual constituent components. This has significant benefits in improving designer materials, energy production, information storage, and drug design.Read moreRead less
Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary ....Nanoelectromechanical Mass Spectrometry with Molecular Imaging. This project aims to develop new technology to enable simultaneous measurement of the mass and conformation of single molecules. Mass spectrometry and high-resolution microscopy are independent analytical tools used widely to characterise the chemical and physical properties of molecules. This project aims to develop new technology based on advanced nanoelectromechanical systems that combines the capabilities of these complementary instruments. This would enable synchronous measurement of molecular mass and conformation with nanometre resolution. In contrast to current mass spectrometry, this technology could be operated in fluid and detect neutral species. This significant change in capability could be applied to advance biological and medical research.Read moreRead less
Inverse problems with partial data. This project aims to use mathematics, in particular the theory of micro-local analysis, to determine the amount of measurements one needs in order to reconstruct an image by some of the tomography methods commonly used in medical imaging. Expected outcomes of this project include showing that an arbitrarily small set of boundary measurements is sufficient to reconstruct the coefficients of various important partial differential equations such as Schrodinger eq ....Inverse problems with partial data. This project aims to use mathematics, in particular the theory of micro-local analysis, to determine the amount of measurements one needs in order to reconstruct an image by some of the tomography methods commonly used in medical imaging. Expected outcomes of this project include showing that an arbitrarily small set of boundary measurements is sufficient to reconstruct the coefficients of various important partial differential equations such as Schrodinger equation, Dirac operators, and Maxwell equations. In addition to providing a theoretical foundation upon which one can build numerical algorithms, this project will also provide the missing link between inverse problems and unique continuation theory. The downstream impact of this research will lead to more efficient and accurate tomography methods which can be implemented in a range of imaging applications.Read moreRead less
3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabiliti ....3D integrated crystalline UV optical lens-fiber couplers for astronomy. This project aims to create micro-optics for astronomical and bio medical applications by 3D sculpturing them out of crystals by ultra-short pulse lasers. This project will introduce a new 3D fabrication approach of optical probes which have self-aligned micro-optical elements and optical fibres for a wide spectral range and with high quality optical surfaces. Expected outcomes of this project include building new capabilities in micro-optical probes for industrial environments, establishing new solutions for international astronomy partners, and developing new techniques to image through optical fibres. This should provide significant benefits by improving astronomical instrumentation and also lead to less invasive endoscopy.Read moreRead less
Bioinks that Advance 3D bioprinting of cells to the 4th dimension. The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vi ....Bioinks that Advance 3D bioprinting of cells to the 4th dimension. The aim of this research is to provide a simple method for creating complex 3D cell cultures for in vitro cell based assays using 3D printing. A versatile polymer system as a bioink made from entirely commercially available components, will be advanced that gives a full range of soft tissue mimics and which can be dynamically change on-demand after printing of the 3D cell cultures. The latter will provide in vitro mimics of in vivo events never previously possible with more realistic models of what is found in vivo. Applications are in fundamental cell biology, studying diseases and developing new drugs. The outcomes from this research will be new knowledge on designing cheap extracellular matrix mimics and high throughout 3D cell assays.Read moreRead less