Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable ....Quantification of the Remineralisation of Enamel. This project has three specific aims:
1. To quantify the ultrastructure and mechanisms of remineralisation of enamel using scanning and transmission electron microscopy.
2. To determine the mechanical properties of remineralised tissue and compare with those of sound enamel.
3. To develop an in-vivo optical fibre probe for monitoring and quantifying the changes of mineralised carious tissue during remineralisation.
This project will enable patients prone to orthodontic induced root resorption to be identified and also to assist with validating repair of enamel tooth structure in a non-surgical manner. It is anticipated to result in the development of a novel fibre optic instrument with applications beyond dentistry.
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Efficient and tailored supercontinuum generation using dispersion management. Imagine a laser beam, but not with just one colour, but containing all colours. The light beam thus looks white, somewhat like a search light, except that it is much brighter. We now know how to generate such bright white beams of light, but it is expensive, requiring a small specialized laboratory full of equipment. Through a better understanding, we will make it easier and cheaper to generate these light beams. All k ....Efficient and tailored supercontinuum generation using dispersion management. Imagine a laser beam, but not with just one colour, but containing all colours. The light beam thus looks white, somewhat like a search light, except that it is much brighter. We now know how to generate such bright white beams of light, but it is expensive, requiring a small specialized laboratory full of equipment. Through a better understanding, we will make it easier and cheaper to generate these light beams. All kinds of applications that have been known for years, such as medical imaging and chemical analysis, then suddenly become practical. We anticipate that in the future these bright white light beams will be used on a routine basis in Australian hospitals and industry. Read moreRead less
The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the com ....The photonic immunochip: retrieving individual Enzyme-linked Immuno Sorbent Assay (ELISA) array-units using optical waveguide multicolour fluorescence. Improving the sensitivity and availability of in-vitro immuno-diagnostic tests is a critical goal towards developing real time efficient tools for the detection of infectious diseases, cancers, allergies and auto-immune diseases. The goal is to increase the sensitivity of these tests by reducing background noise that has been a feature of the commonly used ELISA technology. This will be achieved by developing a novel optical integrated waveguide array supporting a large range of distributed tests, including several based on a novel multi-colour detection scheme. This massively parallel approach will underpin a new generation of low-cost, efficient diagnostic tests.Read moreRead less
A Three-Dimensional Ultra-Wideband Microwave Method Based On Multiple Antennas For Early Detection Of Breast Cancer. Breast cancer is the most common cause of cancer-related death among women in Australia. In 2003, it killed 2,713 women in Australia and approximately 400,000 worldwide. Despite significant advances, current breast screening methods still suffer from several limitations. They may miss as many as 15% of cancers. Inconclusive results are common, leading to invasive, expensive and pa ....A Three-Dimensional Ultra-Wideband Microwave Method Based On Multiple Antennas For Early Detection Of Breast Cancer. Breast cancer is the most common cause of cancer-related death among women in Australia. In 2003, it killed 2,713 women in Australia and approximately 400,000 worldwide. Despite significant advances, current breast screening methods still suffer from several limitations. They may miss as many as 15% of cancers. Inconclusive results are common, leading to invasive, expensive and painful follow-up tests such as biopsies. About 75% of such biopsies are found to be negative, and this is a major deterrent for women in undertaking breast screening. The proposed project contributes to the cause of finding a more reliable breast cancer detection method, and hence, saving thousands of lives each year.Read moreRead less