Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's intern ....Measurement and imaging of pathogenic and diagnostic iron oxide nanoparticles using proton magnetic resonance. This project is likely to result in new and improved technologies to aid in the management and diagnosis of a range of diseases including iron metabolism disorders such as thalassaemia and neurodegenerative diseases such as Alzheimer's disease. Other aspects of the research may lead to technologies for the early detection of some cancers. The technologies will enhance Australia's international standing in the field of advanced medical imaging and have the potential to be commercialised within the Australian biotechnology sector. During the project, research students will receive high quality multidisciplinary training ensuring the supply of personnel with high-level technical expertise into the future.Read moreRead less
Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to dete ....Coproantigen detection tests for diagnosis of intestinal parasitic nematode infection. The aim of this project is to develop new tests for detection of hookworm and Strongyloides, two common intestinal worm infections of humans. These tests offer the potential to replace current tests, namely stool microscopy and serodiagnosis, both of whose performance is unsatisfactory due to deficiencies in sensitivity, specificity and operator convenience. The tests will rely on monoclonal antibodies to detect parasite products in stool. Such testing technology is amenable to configuration in a robust format, suitable for large-scale manufacture. Given the worldwide prevalence of these parasites, the tests will have a market potential of international significance.Read moreRead less
Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will signific ....Vibration Isolation Technology and Instrumentaion for Geophysical Surveys. Many geophysical exploration instruments are limited in sensitivity by vibration induced noise. New techniques of vibration isolation have been shown to eliminate vibration induced noise in a vibrating wire magnetic gradiometer. This project will create fully integrated sensor ?isolation packages for airborne and underwater applications, both for gradiometers and for ground penetrating radars. The project will significantly benefit the mineral exploration industry as well as underwater detection of cables and ship wrecks.Read moreRead less
Optimisation of cell culture and molecular typing for the characterisation of Cryptosporidium in water. Cryptosporidium is an important waterborne agent of diarrhoeal disease in people and animals. Improved methods for accurately detecting viable parasite stages recovered from water are a priority research need for the water industry. They are dependent upon improved in vitro cultivation procedures that can be combined with DNA-based assays for identifying species and strains of Cryptosporidi ....Optimisation of cell culture and molecular typing for the characterisation of Cryptosporidium in water. Cryptosporidium is an important waterborne agent of diarrhoeal disease in people and animals. Improved methods for accurately detecting viable parasite stages recovered from water are a priority research need for the water industry. They are dependent upon improved in vitro cultivation procedures that can be combined with DNA-based assays for identifying species and strains of Cryptosporidium and closely related protozoa recovered from freshwater. This project addresses these needs in a collaborative study between scientists at Murdoch University with expertise in both in vitro cultivation and genetic characterisation of Cryptosporidium, and scientists from two of the major water utilities in Australia.Read moreRead less
Advanced Electromagnetic Sensors and Magnetic Gradiometers for Natural Resources Exploration and Future Space Missions. Australia will benefit from the long-standing world-class mining exploration industry. The new magnetic gradiometer system would greatly enhance their arsenal of geophysical exploration tools, especially for the detection of both magnetically and/or conductive minerals like nickel sulphide. Due to the inherent skin depth issues of conductive cover, a unique condition in Austral ....Advanced Electromagnetic Sensors and Magnetic Gradiometers for Natural Resources Exploration and Future Space Missions. Australia will benefit from the long-standing world-class mining exploration industry. The new magnetic gradiometer system would greatly enhance their arsenal of geophysical exploration tools, especially for the detection of both magnetically and/or conductive minerals like nickel sulphide. Due to the inherent skin depth issues of conductive cover, a unique condition in Australia, a low frequency electromagnetic survey system is one of the best methods to penetrate the cover and investigate deeper geological structures. The low frequency isolation system developed in this project will improve the survey instrument performance down to 4Hz, providing capability to explore resources about 50-100% deeper than existing instrumentation allows.Read moreRead less
Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected ....Experiments with Advanced Isolation Systems, Suspension and Test Masses Using ACIGA's High Optical Power Test Facility. This proposal will allow experimental verification of the performcane of of sapphire test masses and their associated isolation and suspension system in ACIGA's high optical power test facility at Gingin. The work will contribute to the worldwide effort to increase the sensitivity of laser interferometers to the level where known sources of gravitational waves can be detected at a reasonable rate.Read moreRead less
Novel High-Q Resonant Structures for Space and Telecommunications. High-Q microwave resonators with low spurious mode density have important applications in telecommunications, radar, navigation, precision metrology and time standards. We will develop high-Q resonators by constructing a dielectric Bragg resonators using monocrystalline sapphire loaded in a copper cavity with new cylindrical and spherical geometries. Based on these devices, compact and economical state-of-the-art ultra-low noise ....Novel High-Q Resonant Structures for Space and Telecommunications. High-Q microwave resonators with low spurious mode density have important applications in telecommunications, radar, navigation, precision metrology and time standards. We will develop high-Q resonators by constructing a dielectric Bragg resonators using monocrystalline sapphire loaded in a copper cavity with new cylindrical and spherical geometries. Based on these devices, compact and economical state-of-the-art ultra-low noise microwave oscillators and hydrogen masers will be built for the telecommunications market and space applications.Read moreRead less
Molecular tools for controlling pathogenic viruses in the seed potato industry. In this project, molecular diagnostic tools will be generated that will improve the ability of testing laboratories to deliver cost-effective virus diagnostic services to seed potato certification authorities in Australia. There will be economic benefits from increased yields of fresh and processing potatoes, higher prices in domestic and export markets, expansion of current and development of new markets, and licen ....Molecular tools for controlling pathogenic viruses in the seed potato industry. In this project, molecular diagnostic tools will be generated that will improve the ability of testing laboratories to deliver cost-effective virus diagnostic services to seed potato certification authorities in Australia. There will be economic benefits from increased yields of fresh and processing potatoes, higher prices in domestic and export markets, expansion of current and development of new markets, and licensing of tests. There will also be economic and social returns to the broader rural community by better management and control of virus pathogens, and less reliance on environmentally undesirable chemical control measures. The project will provide expert training of two PhD students in practical and molecular plant virology. Read moreRead less
High Performance Microwave Oscillators for Radars, Comminication Systems and Precision Noise Measurements. The aim of the project is to develop a new class of microwave oscillators with unique combination of properties including low-noise, high frequency stability and reduced sensitivity to vibration. Such oscillators are essential for expanding fields of radar, fiber optics, optical frequency synthesis and metrology.
The industrial partner's focus will be on demands for reduced cost and impro ....High Performance Microwave Oscillators for Radars, Comminication Systems and Precision Noise Measurements. The aim of the project is to develop a new class of microwave oscillators with unique combination of properties including low-noise, high frequency stability and reduced sensitivity to vibration. Such oscillators are essential for expanding fields of radar, fiber optics, optical frequency synthesis and metrology.
The industrial partner's focus will be on demands for reduced cost and improved environmental performance, the university team will focus on improved frequency stability, optimal tuning and novel vibration immunity techniques.
Achieving the project goals will broaden the international markets for the industry partner's products and lead to increased export income for Australia.
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Development of Optical Clocks and Their Applications to Precision Frequency Measurements and Time Keeping. The goal of the proposed international researcher exchange program is to enhance the ongoing collaboration between the Frequency Standards and Metrology (FSM) Group at the University of Western Australia and leading US research institutions, including National Institute of Standards and Technology (NIST) in the field of (i) laser cooled atomic frequency standards, (ii) methods of optical ....Development of Optical Clocks and Their Applications to Precision Frequency Measurements and Time Keeping. The goal of the proposed international researcher exchange program is to enhance the ongoing collaboration between the Frequency Standards and Metrology (FSM) Group at the University of Western Australia and leading US research institutions, including National Institute of Standards and Technology (NIST) in the field of (i) laser cooled atomic frequency standards, (ii) methods of optical frequency synthesis and coherent time transfer between widely separated parts of electromagnetic spectrum and (iii) generation of low noise microwave signals directly from frequency stabilised ultra-fast pulsed lasers.Read moreRead less