Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical ....Intravital super-resolution imaging via Stimulated Emission Depletion microscopy (STED)-microendoscopy. We will develop a new technology to enable the imaging of sub-cellular structures within a biological specimen, with super-resolution. This intravital super-resolution imaging technology will build off world leading techniques to image objects with super-resolution and to perform this within a specimen, with minimal invasion. The broad ramifications of this technology apply to biology, medical science, imaging and sensing. Important applications include the early detection of debilitating diseases and the advancement of understanding of cellular biology. This research will raise Australia's profile as a world leader in science and technology, building on our emerging presence in the biophysical sciences.Read moreRead less
Optomechanical metrology: pushing optical sensing to its limit. This project aims to pioneer technologies to observe and control the microscopic world with unprecedented precision, and apply them to realise practical sensors with unrivalled performance. Nano- and micro-scale sensors will be developed that resolve motion smaller than an atomic nucleus, in a classical spin-off from international efforts to study quantum physics at the nanoscale. Record precision will be achieved in thermometry and ....Optomechanical metrology: pushing optical sensing to its limit. This project aims to pioneer technologies to observe and control the microscopic world with unprecedented precision, and apply them to realise practical sensors with unrivalled performance. Nano- and micro-scale sensors will be developed that resolve motion smaller than an atomic nucleus, in a classical spin-off from international efforts to study quantum physics at the nanoscale. Record precision will be achieved in thermometry and magnetometry. New tools will be developed for lab-on-a-chip medical diagnosis and thermal imaging, that in future could allow femtolitre diagnosis of blood diseases such as malaria, on-chip genomic analysis, more efficient airport screening, and more precise satellite maps of global and atmospheric temperature.Read moreRead less
Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanopart ....Early-Stage Medical Diagnostics by Plasmon-Mediated Gas Sensing. This project will investigate the use plasmonic absorption of light in metal nanostructures to activate the selective oxidation/reduction of a gas molecule on a semiconductor nanoparticle. This concept will be used with the aim of developing a sensing technique capable of measuring ultra-low concentrations (ppb) of breath markers for lung cancer detection. It is expected that porous sensing films of semiconductor and metal nanoparticles with well-defined light absorption properties will be fabricated. Superior selectivity will be achieved by matching the wavelength of the absorbed light with the required activation energy for oxidation/reduction. Successful outcomes will enable multi-analyte fingerprint identification by on-chip devices with applications ranging from portable medical diagnostics to national security.Read moreRead less