ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a mo ....Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.Read moreRead less
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347223
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Quantitative PCR facility for New England region of NSW. The project will deliver the first real-time PCR facility in the New England Region of NSW for use by University, CSIRO and Industry scientists. The facility will be based at the University of New England and be used by animal scientists, molecular biologists, parasitologists, immunologists and botanists at these institutions, in many cases in collaborative research projects. It will also support the training of seven PhD students and a po ....Quantitative PCR facility for New England region of NSW. The project will deliver the first real-time PCR facility in the New England Region of NSW for use by University, CSIRO and Industry scientists. The facility will be based at the University of New England and be used by animal scientists, molecular biologists, parasitologists, immunologists and botanists at these institutions, in many cases in collaborative research projects. It will also support the training of seven PhD students and a post-doctoral fellow. The facility will be unique to the region and will remove our current need to use facilities in Brisbane or Sydney.Read moreRead less
Higher order curvature flow of curves and hypersurfaces. This project aims to analyse higher order geometric partial differential equations that have important mathematical applications in differential geometry of submanifolds as well as practical applications in physics and mathematical biology. The project aims to prove new general principles that reveal properties of these higher order elliptic and parabolic partial differential equations, producing a unified framework with applications to va ....Higher order curvature flow of curves and hypersurfaces. This project aims to analyse higher order geometric partial differential equations that have important mathematical applications in differential geometry of submanifolds as well as practical applications in physics and mathematical biology. The project aims to prove new general principles that reveal properties of these higher order elliptic and parabolic partial differential equations, producing a unified framework with applications to various specific problems. This project aims to increase Australia's research capacity in geometric evolution problems, provide training for some of Australia's next generation of mathematicians and build Australia's international reputation for significant research in geometric analysis.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE200101834
Funder
Australian Research Council
Funding Amount
$418,410.00
Summary
The structure of singularities in geometric flows. The proposed research aims to develop our understanding of the structure of singularities in mean curvature and related flows, with certain applications in mind.
Discovery Early Career Researcher Award - Grant ID: DE180100110
Funder
Australian Research Council
Funding Amount
$343,450.00
Summary
Analysis of fully non-linear geometric problems and differential equations. This project aims to investigate non-linear geometric evolution equations that have received considerable attention in the past decades through their use in solving outstanding problems in mathematics, such as the Poincare conjecture. By developing innovative new techniques intertwining geometry and analysis, the project endeavours to make advances in non-linear problems modelling complex phenomena. The project addresses ....Analysis of fully non-linear geometric problems and differential equations. This project aims to investigate non-linear geometric evolution equations that have received considerable attention in the past decades through their use in solving outstanding problems in mathematics, such as the Poincare conjecture. By developing innovative new techniques intertwining geometry and analysis, the project endeavours to make advances in non-linear problems modelling complex phenomena. The project addresses topics as varied as hyperbolic geometry, and a geometric approach to irregularities forming in crystal growth in materials science, focusing on developing cutting-edge mathematical tools and connections to geometry.Read moreRead less
Parabolic methods for elliptic boundary value problems. This project aims to uncover new results for second order nonlinear elliptic partial differential equations via the use of uniqueness properties of solutions for related nonlinear parabolic partial differential equations. This will build on theory for fully nonlinear equations developed over the last 30 years. The project expects to generate new knowledge in the theory that will guide future research and have direct impact to applications ....Parabolic methods for elliptic boundary value problems. This project aims to uncover new results for second order nonlinear elliptic partial differential equations via the use of uniqueness properties of solutions for related nonlinear parabolic partial differential equations. This will build on theory for fully nonlinear equations developed over the last 30 years. The project expects to generate new knowledge in the theory that will guide future research and have direct impact to applications in optimal transport, geometric problems and more applied areas including image analysis and mathematical finance. The project will enhance Australia's international reputation for research in the field and train some of the next generation of mathematical analysts.Read moreRead less