Identification Of Glaucoma Susceptibility Variants By Exome Sequencing In Extended Pedigrees Showing Prior Evidence Of Gene Segregation.
Funder
National Health and Medical Research Council
Funding Amount
$694,002.00
Summary
Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for tr ....Primary open angle glaucoma is a chronic eye disease and one of the leading causes of visual impairment and blindness worldwide. This study will use cutting-edge genetic methods to look at the entire coding component of the human genome (exome) in 271 individuals from large glaucoma families. Our previous studies have shown that these families carry genetic variants that increase disease risk. In this investigation we aim to identify these genes, with the hope they may offer novel targets for treatment or diagnosis.Read moreRead less
From The Synchrotron To The Clinic: Translation Of A Novel Functional Lung Imaging Technology
Funder
National Health and Medical Research Council
Funding Amount
$891,834.00
Summary
Our team has recently developed a synchrotron technology with a startling capacity for dynamic functional imaging that can act as a sensitive regional indicator of lung disease. We will demonstrate that this technology can be translated from the synchrotron to the lab and eventually the clinic. We will provide proof of this concept by the application of this technology to emphysema, asthma, lung cancer, cystic fibrosis lung disease and neonatal resuscitation.
ARC Centre of Excellence for Electromaterials Science. The ARC Centre of Excellence for Electromaterials Science (ACES) will create next generation electrochemical devices via the precision assembly of nano/micro dimensional components into macroscopic structures. Through the discovery of new materials and structures, and understanding how spatial arrangement in 3D influences chemical, physical and biological properties, ACES will define the cutting edge of Electromaterials Science. The resultin ....ARC Centre of Excellence for Electromaterials Science. The ARC Centre of Excellence for Electromaterials Science (ACES) will create next generation electrochemical devices via the precision assembly of nano/micro dimensional components into macroscopic structures. Through the discovery of new materials and structures, and understanding how spatial arrangement in 3D influences chemical, physical and biological properties, ACES will define the cutting edge of Electromaterials Science. The resulting technology breakthroughs will have a direct impact on some of today's most challenging global problems in clean energy, synthetic biosystems, diagnostics and soft robotics. National benefit to Australia will be realised through the creation of new manufacturing industries.Read moreRead less
The endangered swift parrot as a model for managing small migratory birds. Endangered swift parrots use variable locations while breeding in eastern Tasmania and over winter on the Australian mainland. This project aims to develop effective conservation strategies for swift parrots and other migrants using new and long term data and innovative technological solutions to tracking small birds across vast landscapes.
Restoring resilience in wildlife populations. This project will be the first to develop landscape models of habitat quality for wildlife that are based on a mechanistic, animal-centric approach to quantifying habitat. This will be an important step in understanding the habitat elements that wildlife need to live in altered landscapes, with implications central to restoration and revegetation.
Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professiona ....Predicting health, well-being, and educational success in emerging adults: An 8 year longitudinal study. This project will inform the community about factors that affect the psychological, physical, academic, and employment outcomes of emerging adults. It will improve our knowledge of why some young people do not reach their full potential. The project will provide a comprehensive assessment of factors associated with well-being across several domains. It will better equip and assist professionals to identify early those youth at risk of having poor psychological, health, and employment prospects post-school. The project will inform the development of intervention programs for young people and maximise their overall adjustment and well-being several years later.Read moreRead less
Student retention beyond the compulsory schooling years in rural, regional and disadvantaged communities. This project will incorporate longitudinal mixed-methods study to investigate the factors that influence student retention in schooling beyond the compulsory years in rural, regional and disadvantaged communities. Research outcomes will identify best-practice educational strategies to enhance retention in such communities across Australia.
Managing urban trees. Managing urban trees. This project aims to explore the effects of different urban tree types and plantings on people and wildlife in Melbourne, Moreland and Ballarat so they can better plan their future urban forests. Local governments spend millions of dollars planting and maintaining urban trees every year. Research provides little guidance to these land managers when making critical decisions in a rapidly changing social and physical environment. This project will combin ....Managing urban trees. Managing urban trees. This project aims to explore the effects of different urban tree types and plantings on people and wildlife in Melbourne, Moreland and Ballarat so they can better plan their future urban forests. Local governments spend millions of dollars planting and maintaining urban trees every year. Research provides little guidance to these land managers when making critical decisions in a rapidly changing social and physical environment. This project will combine tree inventory data with new information on the social and ecological effects of trees (e.g. human well-being, bird diversity). This research is expected to guide future tree management decisions that have better social and environmental outcomes for Australia’s cities.Read moreRead less
Aboriginal patch burning and the quest for sustainable fire management. This project aims to document historical changes in the spatial grain of the patch burning mosaic in an Arnhem Land savannah with an unbroken history of management by Aboriginal people, and in adjacent areas where traditional management has ceased. The mosaic's spatial grain will be inferred by mapping the individual ages of the long-lived conifer Callitris intratropica. Prior research has shown that Callitris individuals c ....Aboriginal patch burning and the quest for sustainable fire management. This project aims to document historical changes in the spatial grain of the patch burning mosaic in an Arnhem Land savannah with an unbroken history of management by Aboriginal people, and in adjacent areas where traditional management has ceased. The mosaic's spatial grain will be inferred by mapping the individual ages of the long-lived conifer Callitris intratropica. Prior research has shown that Callitris individuals can be reliably aged, and population structures are very sensitive to fire regimes: saplings only establish if unburnt for 10 years. This research is expected to provide the first direct test of the hypothesis that Aboriginal people maintained fine-grained fire mosaics in savannas, and inform bushfire policy debates.Read moreRead less