Microscale microRNA Detection and Delivery for Effective Point-of-Care Cancer Screening and Therapeutics. MicroRNAs are short RNA molecules that play a critical regulatory role in gene expression. Recently discovered in 1993, microRNA research has since received considerable attention and is regarded as an emerging revolutionary frontier in medicine given its therapeutic ability to ‘turn off’ certain genes that lead to various diseases. Additionally, microRNA expression signatures are a strong b ....Microscale microRNA Detection and Delivery for Effective Point-of-Care Cancer Screening and Therapeutics. MicroRNAs are short RNA molecules that play a critical regulatory role in gene expression. Recently discovered in 1993, microRNA research has since received considerable attention and is regarded as an emerging revolutionary frontier in medicine given its therapeutic ability to ‘turn off’ certain genes that lead to various diseases. Additionally, microRNA expression signatures are a strong biomarker for many diseases such as cancer. This project will advance the chip-scale acoustic microcentrifugation and nebulisation technology we recently pioneered to overcome the significant hurdles currently faced in microRNA detection and delivery with the aim of developing prototype portable microdevices for early stage cancer screening and therapy.Read moreRead less
Developing mathematical models and statistical methods to understand the dynamics of infectious diseases: stochasticity, structure and inference. Infectious diseases remain a major contributor to mortality and illness worldwide. The potential for future severe pandemics also continues to present a substantial threat to our health and well-being. Mathematics and statistics are increasingly becoming part of the arsenal used by governments to combat the invasion and spread of infectious diseases. I ....Developing mathematical models and statistical methods to understand the dynamics of infectious diseases: stochasticity, structure and inference. Infectious diseases remain a major contributor to mortality and illness worldwide. The potential for future severe pandemics also continues to present a substantial threat to our health and well-being. Mathematics and statistics are increasingly becoming part of the arsenal used by governments to combat the invasion and spread of infectious diseases. In such work, three themes have emerged as having the potential to revolutionise the modelling of infectious diseases: stochasticity, structure (both age and spatial), and inference. This project will develop state-of-the-art techniques, at the interface of these themes, of critical importance to understanding the dynamics of infectious diseases.Read moreRead less
Investigating Bushfire Evacuation Travel Behaviour in High-risk Communities. This project aims to investigate how and why people in popular bushfire-prone communities make travel-related decisions during bushfire evacuation. Rapid bushfire spread and limited transport capacity in densely populated areas at the rural interface create the ‘perfect storm’ for deaths and injuries. Missing from our knowledge is the role of human behaviour in such outcomes. Applying insights from social and computer s ....Investigating Bushfire Evacuation Travel Behaviour in High-risk Communities. This project aims to investigate how and why people in popular bushfire-prone communities make travel-related decisions during bushfire evacuation. Rapid bushfire spread and limited transport capacity in densely populated areas at the rural interface create the ‘perfect storm’ for deaths and injuries. Missing from our knowledge is the role of human behaviour in such outcomes. Applying insights from social and computer sciences to engineering models, this project expects to generate new theory on resident and visitor evacuation travel behaviour in vulnerable areas during bushfires. Expected outcomes of this project include improvements to the tools used for community preparedness and response to increase Australia’s resilience to bushfires. Read moreRead less
How emotion shapes perception: delineating structural, temporal, and representational properties of emotion-induced blindness. Emotion helps shape conscious perception, with implications for public safety and mental health. This project will reveal mechanisms underlying emotion’s impact on perception. In doing so, it will advance theoretical understanding of basic processes and of how perceptual mechanisms might operate within and inform treatment of emotional disorders.