Variation in the arginine vasopressin 1a receptor (AVPR1a) gene, the social environment, general health and wellbeing. The project aims to investigate how the arginine vasopressin 1a gene affects gene expression and influences social behaviour and ultimately health and wellbeing. This research will contribute to understanding the importance of individual differences in social policy and interventions aimed at improving health and wellbeing.
Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to ....Digging deeper to improve yield stability. This project aims to provide innovative breeding solutions that harness the ‘hidden’ part of the plant, roots, to support the development of more productive crops in the face of climate variability. The project expects to generate new insights into the biology and genetics of root development in barley, a model cereal crop, by applying cutting-edge genome editing, phenotyping and genomics technologies. Anticipated outcomes include novel methodologies to accelerate breeding for diverse production environments, with direct applications in barley, and other major cereals including wheat and oats. This should provide significant economic and social benefits to the Australian grains industry through yield stability amidst climate variability.Read moreRead less
Enabling Molecular Plant Breeding for Drought Adaptation Using Genome-to-Phenome Modelling Technologies. Effective molecular plant breeding for improved water productivity of sorghum would generate significant economic and social benefits for rural communities in NE Australia. There is a significant opportunity to expand the sorghum industry in the region. Despite the global financial crisis, global demand for meat continues to increase, generating strong demand from intensive livestock industri ....Enabling Molecular Plant Breeding for Drought Adaptation Using Genome-to-Phenome Modelling Technologies. Effective molecular plant breeding for improved water productivity of sorghum would generate significant economic and social benefits for rural communities in NE Australia. There is a significant opportunity to expand the sorghum industry in the region. Despite the global financial crisis, global demand for meat continues to increase, generating strong demand from intensive livestock industries for feed grain. Price is projected to return to high levels given continuing use of major feed grains for biofuel. A 10% increase in sorghum production would add net value of $48M annually, much via employment. The scientific content of this project positions Australia at the leading edge globally in this emerging research field. Read moreRead less
TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. ....TraitCapture: Genomic modelling for plant phenomics under environmental stress. This project aims to develop software to integrate new hyper-spectral and 3D growth models of plant phenomics with population genomics to identify heritable developmental traits across varied environments. Genome wide association studies aim to then be used to identify causal genes. Functional structural plant models incorporating genetic variation will be used to predict growth under simulated stress environments. The research team unites international industry, the Australian Plant Phenomics Facility, and university statistical geneticists. TraitCapture software will use open standards applicable to both controlled and field environments enabling plant breeders to pre-select adaptive traits to increase crop productivity under environmental stress.Read moreRead less
Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
AusDiab 3: Emerging Risk Factors For And Long-term Incidence Of Cardio-metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,616,397.00
Summary
This study will track 11,000 Australian adults over 12 years to determine how many develop diabetes, obesity, kidney and heart disease. The study will develop ways to best predict those who are going to develop these conditions before they have arisen, and will explore a range of novel risk factors to better understand these conditions.
ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit ne ....ARC Centre in Bioinformatics. The Australian Centre for Genome-Phenome Bioinformatics will examine how the genome comes to life in the mammalian cell during differentiation and development. We will model, visualise and experimentally validate the complex cellular systems and regulatory networks that control the transformation of genomic information into biological structure and function. We will develop novel approaches and tools to improve health, optimise agricultural production and exploit new cell technologies. The Centre will build critical mass and national focus in bioinformatics to generate the human capital and intellectual property that Australia needs to compete in advanced bioscience and biotechnology.Read moreRead less
Novel Insights Into The Pathobiology Of Alphavirus Infections
Funder
National Health and Medical Research Council
Funding Amount
$827,660.00
Summary
Infections with mosquito-borne viruses are increasing at an alarming rate worldwide. Ross River virus is endemic in parts of Australia, PNG and Pacific islands, while chikungunya virus is distributed globally and causes recurrent pandemics that involve millions of people. These viruses cause severe musculoskeletal disease for several months after infection. This project aims to establish how these viruses interact with the human host to cause disease and may provide a basis for new treatments.
Special Research Initiatives - Grant ID: SR0354500
Funder
Australian Research Council
Funding Amount
$10,000.00
Summary
ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
- ....ARC Research Network in Microarray Technology. The primary aim of this proposal is to transform the premier genomic technology into a standard research tool; microarrays are now a priority for anyone studying the genetics underlying key biological processes. A principal challenge for the Australian research community is to capture all aspects of microarray technology and make them readily available. We will address these needs by developing a network to:
-establish regular research meetings,
-facilitate training in array methodologies and bioinformatics,
-co-ordinate innovation of technologies,-provide centralised data warehousing,
-provide access to automated high-level gene annotation,
-provide data mining tools,
-set standards for data management and exchangeRead moreRead less
A National Population-based Study Of Rheumatic Heart Disease In Pregnancy
Funder
National Health and Medical Research Council
Funding Amount
$877,826.00
Summary
Whilst overall a rare disease, Indigenous peoples have disproportionately high rates of rheumatic heart disease (RHD). This study explores the prevalence and distribution of RHD in pregnancy in Australia and New Zealand. It details current management, diagnostic and referral process and risk factors. Key attributes of culturally safe models of care for RHD in pregnancy are explored, particularly as they relate to Indigenous women. Findings will inform policy, guidelines and education resources.