ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the ....ARC Centre for Kangaroo Genome. In this Australian-led Kangaroo Genome Project, we will map and characterize the tammar wallaby genome at the molecular level. Marsupial genomes are uniquely valuable because they provide comparisons that reveal new human genes, regulatory sequences and marsupial-specific genes. These will deliver new products and information useful for medicine, industry, agriculture and conservation. We will construct integrated genetic and physical maps of the genome, clone the whole genome as large inserts in BAC vectors, and build a "golden path" with minimal overlap. We will construct libraries of expressed genes from tammar tissues and array them for use in analysing gene expression.Read moreRead less
DYRK1A As A Novel Target For Glioblastoma Therapies
Funder
National Health and Medical Research Council
Funding Amount
$620,294.00
Summary
Glioblastoma is a form of brain cancer that is currently incurable. We have discovered that switching-off an enzyme called DYRK1A (using ‘DYRK1A inhibitors’) kills glioblastoma cells. This therapeutic advantage is even greater when combined with drugs approved for other cancers. This project will develop new DYRK1A inhibitors and examine a novel combination treatment for glioblastoma patients. This could initiate a novel therapy that could significantly extend patients’ lives.
EPIGENETIC REPROGRAMMING OF MALIGNANT BREAST CANCER
Funder
National Health and Medical Research Council
Funding Amount
$863,268.00
Summary
Poorly differentiated breast cancers are aggressive tumors, frequently resistant to chemotherapy and associated with high morbidity. Herein we propose the engineering of more selective therapeutic agents able to target the genes involved in cancer initiation and resistance to treatment. We aim to correct and reprogram the cancer cell genome in state that is similar to normal, not tumorigenic cells. This work will generate novel forms of treatment for cancers that are presently not curable.
Work-related fatal and non-fatal accidents and injuries and exposure to workplace hazards in migrant workers in Australia. Do migrants have worse workplace conditions and more work-related accidents and injuries than Australian-born workers? This project will analyse national deaths and hospital discharge data, and determine best practice methods to include migrant workers in a future cross-sectional study looking at occupational health and safety.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0667981
Funder
Australian Research Council
Funding Amount
$200,000.00
Summary
Kangaroo Genome Resource Management Facility. Increasingly, large Australian multicentre research programs in biological and medical sciences have a genomics component that involves integration of biological information with sequencing data. The success of these research programs depends on rapid internet access to the research information by all participating scientists. The universal design of the proposed information management system means that it can be easily adapted to support a broad ran ....Kangaroo Genome Resource Management Facility. Increasingly, large Australian multicentre research programs in biological and medical sciences have a genomics component that involves integration of biological information with sequencing data. The success of these research programs depends on rapid internet access to the research information by all participating scientists. The universal design of the proposed information management system means that it can be easily adapted to support a broad range of research programs. The development of this software program therefore has the potential to benefit research scientists, academics and students in many related fields, as well as the broader community, through enhancing research outcomes.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100157
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information th ....Confocal and single molecule microscopes for systems microscopy. This project aims to establish Australia’s first system microscopy facility with dedicated live-cell confocal and single-molecule fluorescence microscopes. In systems microscopy, the imaging workflow is automated so that large and unbiased data sets of the spatiotemporal organisation of molecules and cells can be generated. Combined with statistical and bioinformatics analyses, image-derived data provides system-wide information that is not easily obtainable with other approaches. The project will enable Australian researchers to image and analyse the full complexity of biological systems, potentially transforming cell biology, drug development and understanding the molecular basis of disease. It will also demonstrate how the capacity of microscopy facilities can be enhanced and bias in imaging data reduced by automating data acquisition and mining of image-based data.Read moreRead less
Developmental pathways to health, education and delinquency outcomes in Western Australia children: a holistic approach to inform early intervention strategies. This project will pioneer population-level data linkages between WA's population health databases and information held by the WA Departments of Education (numeracy and literacy), Justice (juvenile delinquency), Disabilities, and Community Development (child protection). The project will describe temporal, regional, socioeconomic and raci ....Developmental pathways to health, education and delinquency outcomes in Western Australia children: a holistic approach to inform early intervention strategies. This project will pioneer population-level data linkages between WA's population health databases and information held by the WA Departments of Education (numeracy and literacy), Justice (juvenile delinquency), Disabilities, and Community Development (child protection). The project will describe temporal, regional, socioeconomic and racial patterns of developmental outcomes, key risk and protective factors and identify pathways to health and wellbeing, education and juvenile delinquency outcomes among WA children and youth, including those who have had contact with the Child Protection System. Outcomes for specific groups identified as ät risk" will also be examined".Read moreRead less
Performance and image enhancing drug injecting in Australia. This project aims to research the use of performance and image-enhancing drugs (PIED), to understand the associated social practices and to assess what health information PIED injectors need. PIEDs use is increasing in Australia and is associated with serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV). Little is known about PIED injecting and the nation's harm reduction framework is u ....Performance and image enhancing drug injecting in Australia. This project aims to research the use of performance and image-enhancing drugs (PIED), to understand the associated social practices and to assess what health information PIED injectors need. PIEDs use is increasing in Australia and is associated with serious health issues, including the transmission of blood-borne viruses, especially hepatitis C (HCV). Little is known about PIED injecting and the nation's harm reduction framework is unprepared to meet the problems it poses. This project expects to directly inform policy and practice, potentially averting an epidemic of HCV in this population, and aims to minimise HCV transmission among people who inject PIEDs.Read moreRead less
Experiences of addiction, treatment and recovery: An online resource for members of the public, health professionals and policymakers. Alcohol and other drug addiction is a major health and social issue in Australia. Treatment success rates are modest and little is known about how people experience and manage addiction and the stigma that accompanies it. This project will generate new knowledge on alcohol and other drug addiction by applying a proven qualitative methodology to these issues for t ....Experiences of addiction, treatment and recovery: An online resource for members of the public, health professionals and policymakers. Alcohol and other drug addiction is a major health and social issue in Australia. Treatment success rates are modest and little is known about how people experience and manage addiction and the stigma that accompanies it. This project will generate new knowledge on alcohol and other drug addiction by applying a proven qualitative methodology to these issues for the first time. It will produce an effective, innovative online resource for affected Australians, their family and friends, and the wider Australian community including health professionals and policymakers.Read moreRead less
Impediments to uptake and diffusion of take-home naloxone. This project aims to investigate impediments to uptake of ‘take-home’ naloxone (THN), which reverses opioid overdose. Opioid overdose is a major health and social problem in Australia. Programmes to provide opioid consumers with THN to reverse overdose exist in some Australian cities, but uptake in Australia remains minimal. The reasons for this are not well understood. This project will interview opioid consumers, prescribers and pharma ....Impediments to uptake and diffusion of take-home naloxone. This project aims to investigate impediments to uptake of ‘take-home’ naloxone (THN), which reverses opioid overdose. Opioid overdose is a major health and social problem in Australia. Programmes to provide opioid consumers with THN to reverse overdose exist in some Australian cities, but uptake in Australia remains minimal. The reasons for this are not well understood. This project will interview opioid consumers, prescribers and pharmacists to better understand THN, and produce an online resource on experiences of overdose and THN. The aim is to inform those affected by overdose, professionals and the wider Australian community about THN, to support THN distribution, save lives and protect communities.Read moreRead less