Driving Change: Using Emergency Department Data To Reduce Alcohol-related Harm
Funder
National Health and Medical Research Council
Funding Amount
$1,468,026.00
Summary
The proposed project is a system change within partner emergency departments, providing them the information and tools to act on both risky alcohol consumption in individual patients and the sources of alcohol in the community which cause the harm they experience. Most importantly, the proposed public health interventions act as a tool for emergency departments to regularly raise awareness with the public and policymakers regarding the impact of alcohol on patients, clinicians and hospitals.
Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and w ....Investigating memory reliability in intoxicated witnesses of crime. Eyewitness testimony is a crucial piece of evidence for solving a crime. Inaccurate testimony leads to miscarriages of justice such as failed prosecutions or false convictions. Many witnesses and victims are affected by alcohol or other drugs during the crime. This project brings together a multidisciplinary team aiming to improve understanding of how intoxication with different substances affects the reliability of victim and witness memory accuracy. Crucially, crimes are frequently distressing; therefore the interaction between intoxication and stress urgently requires exploration. This project will significantly advance our understanding of key mechanisms behind drug effects on memory, and support fairer judicial outcomes for all. Read moreRead less
Understanding the role of trauma in alcohol and other drug-related problems. This project aims to investigate the relationship between trauma and alcohol and other drug (AOD)-related problems. Using a robust set of qualitative and ethnographic methods, the project expects to advance international knowledge on how experiences of trauma influence AOD consumption, and the diverse factors that shape variation in experience and outcomes for individuals. Expected outcomes include targeted recommendati ....Understanding the role of trauma in alcohol and other drug-related problems. This project aims to investigate the relationship between trauma and alcohol and other drug (AOD)-related problems. Using a robust set of qualitative and ethnographic methods, the project expects to advance international knowledge on how experiences of trauma influence AOD consumption, and the diverse factors that shape variation in experience and outcomes for individuals. Expected outcomes include targeted recommendations to improve AOD responses, policy and trauma-informed AOD care, and increased capacity of the Australian health workforce to respond to trauma and AOD-related problems. This should provide significant benefit by reducing the harms, and economic and social costs associated with AOD consumption.Read moreRead less
Melanotransferrin: A “Missing Link” And A Novel Pharmacological Target For Treatment
Funder
National Health and Medical Research Council
Funding Amount
$613,848.00
Summary
Despite >30 years of research, the precise function of the protein, melanotransferrin (MTf), is unknown. However, we have breakthrough evidence that MTf stimulates WNT signalling as a major driver in cancer progression. We will investigate this hypothesis, which will underpin new cancer therapies. Indeed, we designed a new class of drugs that target the WNT pathway via up-regulating the WNT inhibitor, NDRG1. This drug (DpC) inhibits MTf expression to block tumour cell growth and metastasis.
Developing the capacity to model the impact of interventions that target high-risk drinking among young Australians. Alcohol use is a major contributing factor to social and health problems among young Australians. The project will inform the development of effective policy by providing multidisciplinary research evidence and the capacity to model how various interventions impact on the prevalence of alcohol-related problems.
Heparin-induced Thrombocytopenia And Thrombosis: Better Understanding Of Pathogenesis And Improving Diagnosis And Treatment
Funder
National Health and Medical Research Council
Funding Amount
$653,137.00
Summary
Heparin, a widely used drug, can cause an adverse effect which results in a fall of the platelet count and the development of serious thrombosis. This drug complication is mediated by an immune mechanism. This proposal aims to provide a better understanding of the disease mechanism. It also aims to develop a new test that will improve the diagnosis, and to produce a novel drug that will effectively suppress the immune reaction and improve the treatment.
Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, ....Alcohol’s harm to others: patterns, costs, disparities and precipitants. This project aims to generate understanding of the magnitude, character, economic burden, disparities and precipitants of occurrence of alcohol’s harm to others across Australia, using a national survey, crime, community services and health data and qualitative interviews. The project outcome will be a robust current evidence base for our partners, government and Australian society to underpin advocacy, policy and planning, aimed at reducing alcohol-related harm and suffering.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
An assessment of late night alcohol restrictions in Queensland. An assessment of late night alcohol restrictions in Queensland. This project aims to assess the effect of 2.00am cease of alcohol service for licensed venues across Queensland, identify modifiable elements and develop policy advice. Alcohol-related harm is a major social order issue which requires evidence-based policy. Using the most sophisticated models to date—including outlet density, enforcement, demographic variables and other ....An assessment of late night alcohol restrictions in Queensland. An assessment of late night alcohol restrictions in Queensland. This project aims to assess the effect of 2.00am cease of alcohol service for licensed venues across Queensland, identify modifiable elements and develop policy advice. Alcohol-related harm is a major social order issue which requires evidence-based policy. Using the most sophisticated models to date—including outlet density, enforcement, demographic variables and other variables—this project will build unique datasets, including archival data, foot-traffic counting, key stakeholder and patron interviews, to evaluate the effect of alcohol restrictions and identify policy lessons for other jurisdictions in Australia and internationally.Read moreRead less