Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100174
Funder
Australian Research Council
Funding Amount
$805,000.00
Summary
Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smar ....Urban Analytics Data Infrastructure. Urban analytics data infrastructure:
This project aims to develop an urban analytics data infrastructure that builds on the Australian Urban Research Infrastructure Network. This digital data infrastructure intends to enable the integration, harmonisation, connectivity and scalability of multi-source urban datasets. This infrastructure is required to underpin the next generation of data-driven modelling and decision-support tools to enable the design of smart, productive and resilient cities. These capabilities are predicated on the adoption of ISO standards, development of new ontological frameworks and an urban data dictionary to enable semantic inferencing of datasets and the development of data structures and services. This framework would then be applied to data relevant to people, land and urban infrastructure to support comparative and multi-dimensional analytics. Read moreRead less
Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this fram ....Innovative procurement theories to optimise education per cost of school. Innovative procurement theories to optimise education per cost of school. This project aims to develop a whole-of-life procurement decision-making framework so schools can make delivering better education more cost effective. This framework—which draws on state-of-the-art and Nobel prize-winning theories and a new theory the project will develop—will be used in government and private schools. The effectiveness of this framework in improving schools will be shown using a new approach to make school facilities deliver educational outcomes and account for their total production and transaction costs. This research is expected to deliver more efficient ways to future-proof schools to create a well performing school system and more resilient infrastructure vital to Australia’s future prosperity.Read moreRead less
Innovative learning environments and teacher change. This project aims to bridge a gap between the educational potential of innovative learning environment designs, and their actual performance. Currently, multi-modal technology-enabled spaces are not producing demonstrable benefits for students. Many teachers resist altering their mindset about how students learn effectively in these spaces and thus how teachers should teach differently. The project aims to work with schools, government and ind ....Innovative learning environments and teacher change. This project aims to bridge a gap between the educational potential of innovative learning environment designs, and their actual performance. Currently, multi-modal technology-enabled spaces are not producing demonstrable benefits for students. Many teachers resist altering their mindset about how students learn effectively in these spaces and thus how teachers should teach differently. The project aims to work with schools, government and industry to analyse the relationships between quality teaching and effective use of innovative learning environments. The new understanding gained through the project is expected to guide developments in pedagogy, policy and design and to produce strategies to improve learning in schools across Australia and New Zealand.Read moreRead less
Pharmacology Of Potential Anti-Tumour Agents: Iron Chelators Of The BpT Class
Funder
National Health and Medical Research Council
Funding Amount
$585,455.00
Summary
Pharmacology of Potential Anti-Tumour Agents: Iron Chelators of the BpT Class Cancer cells have a high iron requirement for DNA synthesis and many clinical trials showed Fe chelators are effective anti-cancer drugs. Their potential to act as anti-tumour agents has been confirmed by the entrance of Triapine into widespread NCI clinical trials. In this NHMRC Renewal, we will perform pharmacological and preclinical studies to promote the development of BpT chelators as novel anti-tumour agents.
Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliance ....Confronting everyday harms: preventing abuse of people with disability. The findings of the Disability Royal Commission necessitate new approaches to prevent violence, abuse, neglect and exploitation. Framed by recognition theory, this project proposes empirical research with young people with cognitive disability, using a new concept of ‘everyday harms’ in their paid relationships. The results will inform early responses to poor quality interactions in disability support. The strategic alliances with the government, industry and community partners will develop a practice framework to prevent everyday harms and the escalation to abuse, and to promote safety and wellbeing. The research has policy benefits for capacity-building in the sector to act on the rights and voices of people with disability. Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100133
Funder
Australian Research Council
Funding Amount
$400,000.00
Summary
National Facility for Physical Blast Simulation (NFPBS). Recent terrorist attacks employing large quantities of high explosives have prompted the international demand for experimental investigation of civil infrastructure response to shock wave loadings. The National Facility for Physical Blast Simulation (NFPBS) is one of only a few in the world that are suitable for conducting experimental research via a physically generated blast approach.
Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring tha ....Child health and developmental inequities: Evidence for precision policy. The project aims to use cutting edge analytic approaches applied to existing data to identify how policy interventions related to parents’ mental health, preschool programs, and the built environment can be optimised to reduce inequities in children’s mental, academic, and physical health outcomes. The project will be informed by our partners and advisers from across government portfolios and service delivery, ensuring that the evidence generated has contemporary policy relevance. The project expects to identify clear and actionable policy pathways to reduce child inequities in Australia, which can benefit decision makers by helping them to direct limited public funds towards intervention opportunities that will have the greatest impact.Read moreRead less
Seismic analysis of cracking and deformations in concrete gravity dams. This project aims to establish a rational predictive capability for the responses of concrete gravity dams subject to extreme design earthquakes. This will include the development of innovative numerical methods for effective modelling of crack propagation and closure, large slips on crack faces and weak interfaces, dam-reservoir interaction, dam-foundation interaction and automatic mesh generation. The expected outcomes of ....Seismic analysis of cracking and deformations in concrete gravity dams. This project aims to establish a rational predictive capability for the responses of concrete gravity dams subject to extreme design earthquakes. This will include the development of innovative numerical methods for effective modelling of crack propagation and closure, large slips on crack faces and weak interfaces, dam-reservoir interaction, dam-foundation interaction and automatic mesh generation. The expected outcomes of the project will be a significantly improved prediction tool. It is also anticipated that the project will result in improvements in dam and public safety, and more efficient use of funds for dam safety upgrades and management.Read moreRead less
Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk ....Mental health, job quality and workforce participation: evidence from population health research to address complex problems and conflicting policies. Mental disorders such as depression are a major cause of disability. Improving mental health can increase productivity and workforce participation. However, the psychosocial quality of work is a factor that overlays the relationship between work and health. Poor quality work (for example, unreasonable time pressure, insecurity) increases the risk of poor mental health, absenteeism, and exit from the workforce. This project will analyse data following people over time to investigate the long-term health and employment consequences of poor psychosocial job quality, and consider the special case of mature age workers. It will identify those individuals at greatest risk, and factors that can buffer against the adverse effects of poor quality work.Read moreRead less