Structural And Functional Analysis Of A Cancer-linked Co-regulator Complex
Funder
National Health and Medical Research Council
Funding Amount
$729,571.00
Summary
We seek to understand the mechanisms by which genes are switched on and off throughout our lifetime. A number of multi-component protein machines are involved in this process but their make-up and mechanism of action is not understood. We will investigate the structure and function of one of these machines that has been strongly linked to cancer.
Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for healt ....Designing offices well. This project aims to describe, quantify and analyse the impact of workspace design on workers’ satisfaction, productivity and health. The Australian market is the fastest adopter of Activity-Based Working (ABW) in the world and impacts arising from this workspace typology on workers will be significant now and in the next decade. This project will develop benchmarking for ABW offices, techniques for monitoring cognitive performance in situ, and design guidelines for health promotion. By shifting attention to design features that actually perform well, this project will provide the empirical basis needed to transform the way workspaces are designed now and in the future. It will therefore lead to greater productivity in and among workplaces.Read moreRead less
Offsite manufacture reimagined for high-performance adaptable housing. The project aims to address housing performance and affordability in Australia by deploying adaptable design for spatial reconfiguration and component reuse, to advance offsite timber manufacture towards energy efficient and healthy homes as mainstream practice. The intended outcome is the development, prototyping and monitoring of an offsite manufactured panelised lightweight timber system for high-performance homes, that is ....Offsite manufacture reimagined for high-performance adaptable housing. The project aims to address housing performance and affordability in Australia by deploying adaptable design for spatial reconfiguration and component reuse, to advance offsite timber manufacture towards energy efficient and healthy homes as mainstream practice. The intended outcome is the development, prototyping and monitoring of an offsite manufactured panelised lightweight timber system for high-performance homes, that is adaptable to all Australian climates and long-term household changes. This will contribute to the sustainable growth of the Australian housing market with significant benefits on housing affordability, adaptable design and long-lasting performance, while boosting the offsite manufactured timber construction sector.Read moreRead less
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100130
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure ....An earthquake shaking table to investigate soil-structure interactions. An earthquake shaking table to investigate soil-structure interactions: This project aims to develop Australia's most advanced earthquake shaking table. Earthquakes are a problem of great significance to Australia. Infrastructure in civil, transport, mining and energy sectors may be at an unacceptable risk of damage under earthquake loading as current design practices do not account for the interaction between infrastructure and the ground under such loading. The shaking table will simulate earthquakes and enable controlled testing of three-tonne models of foundation and soil-structure interaction systems typical of Australia's infrastructure. The discoveries made are expected to be integral to the modernisation of Australia's seismic design standards so that earthquake-induced damage and risk exposure can be minimised.Read moreRead less
Optimization of internal pressure for designing industrial buildings. The project seeks to understand the internal pressure in a building during windstorms, to improve safety and performance. The internal pressure in a building is dependent on its volume and flexibility and the sizes of openings in the building envelope, and is a critical loading parameter in building design. Windstorm damage investigations have shown that incorrect internal pressures are frequently used in building design, lead ....Optimization of internal pressure for designing industrial buildings. The project seeks to understand the internal pressure in a building during windstorms, to improve safety and performance. The internal pressure in a building is dependent on its volume and flexibility and the sizes of openings in the building envelope, and is a critical loading parameter in building design. Windstorm damage investigations have shown that incorrect internal pressures are frequently used in building design, leading to damage. This project aims to study the internal pressures generated in buildings with a range of volumes and openings in the envelope. A combination of model-scale and full-scale tests and theoretical analysis are planned to determine critical parameters for highly turbulent air-flow though openings. Results will inform the revision of design data in codes and of guidelines for consistent, optimal design of buildings.Read moreRead less
The design and construction of quality, sustainable and affordable pre-made housing in Australia - optimisation and integration. Historically, industrialised construction has resulted in an industrialisation of the parts, rather than an industrialisation of the ensemble. In contrast, this project will integrate architecture and engineering, as well as construction and development to optimise the ensemble, and deliver architectural quality in industrially produced affordable housing.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE160100138
Funder
Australian Research Council
Funding Amount
$235,000.00
Summary
National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems ....National Drop Weight Impact Testing Facility. National drop weight impact testing facility:
The national drop weight impact testing facility aims to enable dynamic tests on geo- and construction materials and systems. This facility aims to provide state-of-the-art technology to observe the real-time behaviour of elements and sub-assemblies under combined quasi-static and impact loading. Understanding material behaviour under dynamic loading is essential in dealing with many engineering problems. The facility may advance understanding of the fundamental behaviour of critical infrastructure exposed to impact loading and will foster innovations in design and construction. Applications may include improvement of the structural safety of infrastructure including railway networks, tunnels and bridges, and also the development of cost-effective and environmentally friendly building and construction materials. Read moreRead less
Design guidelines for safety-critical controllers in high-risk environments. This project aims to generate novel product design guidelines for developing safer controllers for use by potentially stressed individuals in high-risk situations. It will do this by generating specific insights and verifying generalisable solutions from the context of total artificial heart recipients –who must engage with critical controllers constantly. This project expects to generate new knowledge in design by esta ....Design guidelines for safety-critical controllers in high-risk environments. This project aims to generate novel product design guidelines for developing safer controllers for use by potentially stressed individuals in high-risk situations. It will do this by generating specific insights and verifying generalisable solutions from the context of total artificial heart recipients –who must engage with critical controllers constantly. This project expects to generate new knowledge in design by establishing a new research topic around an under-examined user cohort. Expected outcomes of this project include interaction design theory developments and improved controller design techniques. This should provide significant benefits and competitive advantages by lowering stress and improving safety across a range of contexts.Read moreRead less
Understanding the performance of cold-formed steel frame wall systems in fires to design for superior fire resistance. This project will develop new light gauge steel frame (LSF) wall systems with superior fire resistance rating and associated design rules to enable innovative and safe applications of these wall systems in various building applications. This will enable expansion of the worldwide market for LSF wall systems by the industry partner.