Predicting Drug-drug Interactions Due To Tyrosine Kinase Inhibitors: Inhibition Of Drug Metabolising Enzymes And Transporters
Funder
National Health and Medical Research Council
Funding Amount
$535,495.00
Summary
Tyrosine kinase inhibitors (TKIs) are a new class of anticancer agents. Cancer patients typically receive multiple drugs, for the treatment of cancer and other diseases, increasing the probability of interactions between coadministered drugs. Despite the widespread use of TKIs, their potential to cause drug interactions is poorly understood. Using novel in vitro approaches, this project will identify drug interactions precipitated by TKIs thereby improving drug efficacy and patient safety.
Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. ....Protecting Critical Transport Infrastructure using Hybrid Approaches for Interference and Spoofer Detection and Localisation. Modern infrastructure increasingly relies on the positioning and timing capabilities provided by the Global Navigation Satellite Systems (GNSS). GNSS signals, however, are vulnerable to interference and spoofing attacks. This vulnerability is aggravated as satellite navigation becomes more central to the operation of airports, ports, railways, and communications systems. Building on from earlier work by University of New South Wales, University of Adelaide and GPSat Systems, this project aims to create a system for locating interference and spoofers to GNSS of any power in real time, providing layered monitoring and reactive mitigation solutions against interference and spoofing attacks.Read moreRead less
Situational Assessment as a Marker of Cognitive Skill Decay. The aim of this study is to test how differences in exposure to complex tasks change the capacity for situational assessment. Amongst drivers, pilots and electricity controllers, the capacity to assess and respond effectively to changes in the operational environment are critical in sustaining performance and ensuring the safety and security of the public. Establishing the nature of this relationship will enable, for the first time, ob ....Situational Assessment as a Marker of Cognitive Skill Decay. The aim of this study is to test how differences in exposure to complex tasks change the capacity for situational assessment. Amongst drivers, pilots and electricity controllers, the capacity to assess and respond effectively to changes in the operational environment are critical in sustaining performance and ensuring the safety and security of the public. Establishing the nature of this relationship will enable, for the first time, objective measures of cognitive skill decay. In evaluating cognitive skill decay more accurately, we will provide a cost-effective, easily administered tool, enabling practitioners to identify and address areas of development and providing data to anticipate when cognitive skill decay is most likely to occur.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100079
Funder
Australian Research Council
Funding Amount
$320,000.00
Summary
A haptic-based immersive motion platform for human performance evaluation. A haptic-based immersive motion platform for human performance evaluation: This project aims to establish a motion platform capable of combining continuous centrifugal rotation and large linear displacement with an additional five degrees of motion. The system will house a human subject at the end of a large serial robot similar to a human arm, which can rotate continuously about its base. The robot arm will be installed ....A haptic-based immersive motion platform for human performance evaluation. A haptic-based immersive motion platform for human performance evaluation: This project aims to establish a motion platform capable of combining continuous centrifugal rotation and large linear displacement with an additional five degrees of motion. The system will house a human subject at the end of a large serial robot similar to a human arm, which can rotate continuously about its base. The robot arm will be installed on a large linear axis enabling the simulation of movements and accelerations along a straight path as well as rotation provided by other axes of the robot. The motion platform will comprise audio and visual devices, and haptic-based control mechanisms, for example a steering wheel and pedals or a helicopter cyclic, to provide a number of human immersed scenarios for driving/flying training and human perception evaluation.Read moreRead less
A Novel Metabolic Role For UDP Glycosyltransferase 8 (UGT8)
Funder
National Health and Medical Research Council
Funding Amount
$419,144.00
Summary
The UDP glycosyltransferases (UGTs) are a family of enzymes that remove drugs and toxins from the human body as well as control levels of naturally produced molecules such as bile acids and hormones. We found that a new member of this family called UGT8 processes bile acids in the kidney and intestine and can affect how bile acids act to regulate metabolism. Our studies uncover new roles for bile acids in liver, kidney and gut health and in metabolic disorders such as diabetes and obesity.
Structure And Function Of Antimicrobial Therapies And Their Interaction With Upper Respiratory Biofilms
Funder
National Health and Medical Research Council
Funding Amount
$320,891.00
Summary
Bacterial infections of the upper respiratory tract are a major public health problem affecting millions of Australians. Commonly prescribed antibiotics are often not able to eradicate all bacteria as the bacteria often reside in a protective, self-produced gel-like matrix known as biofilm. This Fellowship aims to unravel the interaction of modern anti-infective therapeutics with the biofilm for the development of the next generation of safe and efficacious anti-biofilm strategies.
The Australian naturalistic driving study: innovation in road safety research and policy. A revolutionary new approach, the naturalistic driving study, will investigate what people actually do when they drive, in normal and safety-critical situations. It will provide Australia with answers to some intractable, high priority, road safety problems that cannot be answered using current methods, thereby saving hundreds of lives.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100050
Funder
Australian Research Council
Funding Amount
$570,000.00
Summary
Integrated facility for recording driver and road user behaviour. The integrated facility will be used to record and analyse data on driver and road user behaviour, in normal and safety-critical situations, for thousands of Australian drivers. The data yielded will be used to develop new and improved countermeasures for reducing road deaths and serious injuries on Australian roads.