Glycine Transporters regulate the concentration of glycine in the spinal cord and brain. It has been suggested that elevating glycine levels in these regions may be useful in treating pain and schizophrenia. This project will provide the basis for the development of new glycine transport inhibitors that may be used to treat these conditions.
Alpha-2-Macroglobulin And The Transport And Uptake Of The Hormone, Hepcidin
Funder
National Health and Medical Research Council
Funding Amount
$533,541.00
Summary
Hepcidin is a peptide hormone that is a major regulator of iron metabolism. It has been suggested that hepcidin is free in the blood. However, we recently identified that hepcidin binds with alpha-2-macroglobulin (a2-M) in the plasma and this increases the efficacy of this peptide. The demonstration that a2-M plays a role in hepcidin biology will lead to a better understanding of hepcidin physiology, the development of methods for its measurement and improved treatment of iron related diseases.
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hyd ....Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hydrogen atoms around micro-scale features and to compare it to local mechanical behaviour, determined by micro-mechanical tests. The systematic investigation of the effect of hydrogen on different micro-components within steel will allow the development of microstructure-guided alloy design principles.Read moreRead less
Development Of A New High Throughput Screen For Drug Binding To HERG K+ Channels
Funder
National Health and Medical Research Council
Funding Amount
$351,320.00
Summary
Inadvertent drug block of hERG, a potassium channel in the heart, can cause cardiac arrhythmias and sudden cardiac death. Screening for hERG toxicity has become a major hurdle for development of new drugs. We will use a mutant hERG protein that has enhanced drug binding to develop a high throughput test for hERG toxicity. Identification of dangerous drugs early in the drug discovery process will save the pharmaceutical industry millions of dollars in the costs of brining new drugs to market.
Discovery And Mechanisms Of Host Cell Factors In HIV Uncoating
Funder
National Health and Medical Research Council
Funding Amount
$635,098.00
Summary
HIV entry into the host cell involves release of its capsid, a protein shell protecting the viral genome. The capsid hijacks host proteins to cloak itself from cellular defenses while the cell has evolved sensors that can block viral infection. This proposal aims to discover proteins involved in this arms race between host and virus and decipher how they control capsid disassembly. This insight will help design new drugs against HIV infection and new ways to deliver genes for gene therapies.
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Inequality, Prosperity and the Australian Welfare State. This project aims to clarify contested understandings of Australian inequality and the role of economic and social policies in addressing policy challenges going forward. The objective of the project is to generate significantly improved knowledge of inequality in Australia using innovative approaches of data splicing, decomposition, simulation and backcasting to fill research gaps and resolve contested interpretations. We aim to provide a ....Inequality, Prosperity and the Australian Welfare State. This project aims to clarify contested understandings of Australian inequality and the role of economic and social policies in addressing policy challenges going forward. The objective of the project is to generate significantly improved knowledge of inequality in Australia using innovative approaches of data splicing, decomposition, simulation and backcasting to fill research gaps and resolve contested interpretations. We aim to provide a benchmark and robust framework against which policy development after the current crisis can be evaluated. This project aims to provide significant benefits, keeping Australia at the forefront of research on inequality and public policy, strengthening links between researchers and policy makers.
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Integrable Functional and Delay Differential Equations. Major challenges such as predicting epidemics or modelling the dynamics of human movement, rely on our understanding of functional and delay differential equations. This research will provide new methods for prediction and analysis of such models.
Child poverty, labour markets and social transfers. This project aims to discover how earnings and social transfers determine the living standards of disadvantaged families with children, and the constraints that wage rates and employment patterns place on social transfer structures. This project will compare the family incomes of disadvantaged children and how the interaction of wage rates, employment and social policies affect them. It will compare Australian outcomes to those in OECD and midd ....Child poverty, labour markets and social transfers. This project aims to discover how earnings and social transfers determine the living standards of disadvantaged families with children, and the constraints that wage rates and employment patterns place on social transfer structures. This project will compare the family incomes of disadvantaged children and how the interaction of wage rates, employment and social policies affect them. It will compare Australian outcomes to those in OECD and middle income countries. This project expects to understand which labour market and social policies combine to lead to the best economic outcomes for disadvantaged families and children.Read moreRead less