Understanding Changes In The Mammalian Prenylome Induced By Statins And Prenyltransferase Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$566,308.00
Summary
Prenylation, the covalent attachment of isoprenoid lipids to proteins, is widespread in mammalian cells. Essential for a protein's normal function, it contributes to the progression of cancer and inflammation. We have developed a novel technology to identify all prenylated proteins in the cell. Aided by this method, we will analyse the effect of statins and anti-cancer drugs on protein prenylation. This will provide guidance in identifying a more effective clinical use for them.
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Understanding the mechanism of Wolbachia-mediated antiviral protection. Insects are involved in the transmission of many viral diseases of both plants and animals. A considerable number of these diseases have adverse effects for public health or cause large economic losses in agriculture. We were the first to discover that a common bacteria protects insects from virus infection. Knowledge of the mechanisms used by the bacteria to interfere with virus accumulation will facilitate novel strategies ....Understanding the mechanism of Wolbachia-mediated antiviral protection. Insects are involved in the transmission of many viral diseases of both plants and animals. A considerable number of these diseases have adverse effects for public health or cause large economic losses in agriculture. We were the first to discover that a common bacteria protects insects from virus infection. Knowledge of the mechanisms used by the bacteria to interfere with virus accumulation will facilitate novel strategies for control of virus disease. The findings of this project will enable Australian researchers and industry to design innovative approaches to control diseases that are transmitted by insects.Read moreRead less
An Investigation Of The Involvement Of Clotting Factors In Abdominal Aortic Aneurysm (AAA) Progression Within A Mouse Model
Funder
National Health and Medical Research Council
Funding Amount
$189,401.00
Summary
Early stage weakening of the main abdominal artery is present in ~100,000 Australians and currently has no accepted therapy. Development of drug therapies which limit progression of the weakening process is urgently needed. In this study involvement of the clotting cascade in artery weakening will be investigated. The study have been planned in order to identify new strategies which can be developed as treatments for artery weakening in patients.
Sustainable operation of transformers with better understanding of technical and economic constraints. Transformer failure can be devastating to consumers and network service providers, costing from thousands to millions of dollars in transformer replacement and lost productivity. To avoid such catastrophic failures, the goal of this project will be to develop new methods that can maximise transformer usage and minimise cost before failure occurs.
Income insecurity in Australia: who is feeling the pinch and why? This project aims to measure and investigate the drivers of income insecurity in Australia. It will provide an evaluation of whether income growth is sufficient to compensate for any welfare loss due to higher income risk and the effectiveness of government taxes and transfers in alleviating income risks for different population sub-groups.
Investigation of key factors affecting the polarisation based diagnostics of power transformers. To avoid system wide power interruptions, major assets in the electricity network must be always operating satisfactorily. One of the key assets in the electricity network is the power transformer. Currently many transformers are over 50 years old and failure of a transformer may result in long interruptions in supply and the loss of millions of dollars in revenue. The ageing of transformers needs to ....Investigation of key factors affecting the polarisation based diagnostics of power transformers. To avoid system wide power interruptions, major assets in the electricity network must be always operating satisfactorily. One of the key assets in the electricity network is the power transformer. Currently many transformers are over 50 years old and failure of a transformer may result in long interruptions in supply and the loss of millions of dollars in revenue. The ageing of transformers needs to be properly monitored to avoid catastrophic failures. This project will provide an innovative solution for the better understanding of the ageing processes of transformers and help
managers make correct decisions for maintenance and replacement strategies.
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Rapidly Locating Items in Distribution Networks with Process-Driven Nodes. Safety-critical product recalls are a major public health issue in Australia. Recent extortion attempts involving poisoning of chocolate bars, paracetamol tablets and biscuits have demonstrated the urgent need for improved ways of locating commercial products that have been released into the community. Existing product recall tools are effective only within regulated manufacturing and warehousing facilities. This project ....Rapidly Locating Items in Distribution Networks with Process-Driven Nodes. Safety-critical product recalls are a major public health issue in Australia. Recent extortion attempts involving poisoning of chocolate bars, paracetamol tablets and biscuits have demonstrated the urgent need for improved ways of locating commercial products that have been released into the community. Existing product recall tools are effective only within regulated manufacturing and warehousing facilities. This project will develop novel techniques for locating items in large-scale distribution networks driven by complex logistic processes. The outcomes of the project will make it easier to rapidly and accurately pinpoint product locations outside controlled facilities, thus contributing to both cost savings and public safety.Read moreRead less
Condition Assessment of Medium-Voltage XLPE-Insulated Cables Degraded by Water Treeing. In Australia degraded underground XLPE cables are causing disruption of electricity supplies and high community costs. There is no reliable non-invasive technique for prediction of cable condition to optimise cable replacement and refurbishment. In this project a large-scale experiment will be undertaken on 22 kV cables to ascertain the effectiveness of a new cable refurbishment technology. New techniques for ....Condition Assessment of Medium-Voltage XLPE-Insulated Cables Degraded by Water Treeing. In Australia degraded underground XLPE cables are causing disruption of electricity supplies and high community costs. There is no reliable non-invasive technique for prediction of cable condition to optimise cable replacement and refurbishment. In this project a large-scale experiment will be undertaken on 22 kV cables to ascertain the effectiveness of a new cable refurbishment technology. New techniques for assessment of cable condition will be developed using unique data from the ageing experiment and computer models of fundamental phenomena. Successful conclusions from this project will save the industry partner and other electricity distribution companies tens of millions of dollars.Read moreRead less
Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water acro ....Innovative approaches to understanding and limiting the public health risks of Cryptosporidium and Giardia in animals in Australian catchments. Sophisticated molecular typing and modelling will be used to determine if chlorine-resistant parasites in animals in catchments are responsible for infection in humans. Improved catchment management and risk mitigation strategies will be developed during this project, which will make a substantial contribution to the provision of safe drinking water across Australia.Read moreRead less