Activation And Inhibition Of The Plasminogen/Plasmin System
Funder
National Health and Medical Research Council
Funding Amount
$800,663.00
Summary
Plasmin is crucial enzyme present in blood plasma that functions in clot dissolution, inflammation, tissue remodeling, and wound healing. We aim to study how this enzyme system is controlled, by studying its interaction with receptors, co-factors and inhibitors. The information we gain will help drive the development of new generation therapeutics for the fine control of plasmin function in clotting disease, bleeding and inflammation.
Epilepsy is one of the most common chronic neurological disorders; it affects 1% of the world’s population, yet about 1 in 3 patients fail to achieve seizure control with current drugs. We will improve the properties of small molecules (drugs) that specifically target the GTPase activity of the enzyme dynamin, to reduce seizure effect in the brain by a novel mechanism. We will optimize and pre-clinically test these future chemical entities as potential anti-epileptic drugs.
Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It w ....Policy Modelling for Ageing in Emerging Economies: The Case of Indonesia. This project, in collaboration with the World Bank and the Indonesian Planning Authority, will support major social and economic policy development in a rapidly ageing region. It will break new ground by developing a cutting-edge economic policy model reflecting salient features of ageing in emerging economies, taking into account the wider implications for education, employment, formalisation, growth, and retirement. It will bring the armoury of policy analysis instruments available to these countries up to the standard now enjoyed by the developed world. Indonesia, on the brink of major pension reform, will be used as a test bed. Data sets will be developed to allow the model structure to be applied to other emerging economies in Asia. Read moreRead less
Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hyd ....Embrittlement-tolerant alloys for safe hydrogen transmission and storage. Hydrogen embrittlement in steels is a major impediment to a safe hydrogen economy. This project will determine how hydrogen affects the deformation behaviour of steel, providing the fundamental information that is required to develop alloys that can be safely used in infrastructure for a future Australian hydrogen industry. We will utilise new technologies that allow us, for the first time, to determine the position of hydrogen atoms around micro-scale features and to compare it to local mechanical behaviour, determined by micro-mechanical tests. The systematic investigation of the effect of hydrogen on different micro-components within steel will allow the development of microstructure-guided alloy design principles.Read moreRead less
Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate fa ....Inequality and economic growth. This project aims to identify forces driving inequality. Piketty’s influential book, Capital in the 21st Century, stimulated research on inequality to address the increased public concern about inequality and its side-effects such as reduced growth. Piketty proposes three laws that explain and predict inequality paths over time, but there is no empirical evidence or theoretical foundations for these laws. This project will examine Piketty’s laws and investigate factors that shape inequality and its relation to growth. This knowledge should enable Australian governments to reduce inequality and benefit economic growth, thereby reducing disadvantage and building stronger, more resilient communities.Read moreRead less
A model of fan involvement, participation and loyalty: a mixed method study on fan behaviour and management in Basketball. This study will build a model of sport fan loyalty in the context of the National Basketball League using ethnographic and survey methods. This will develop a more complete understanding of motives and drivers of fan involvement, participation and loyalty. We will use this to examine the impact of marketing activity on fan loyalty, and to generate recommendations for sports ....A model of fan involvement, participation and loyalty: a mixed method study on fan behaviour and management in Basketball. This study will build a model of sport fan loyalty in the context of the National Basketball League using ethnographic and survey methods. This will develop a more complete understanding of motives and drivers of fan involvement, participation and loyalty. We will use this to examine the impact of marketing activity on fan loyalty, and to generate recommendations for sports organisations and government agencies seeking to engender greater interest and interaction in sport, particularly amongst young Australians. A further aim is to develop a more comprehensive understanding of consumer loyalty than the limited view that presently exists in the marketing literature. The study will be carried out via two APAI under the supervision of the CIs.Read moreRead less
Cryogenic pipelines to replace trestle for liquefied gas transfer terminals. This project aims to develop geotechnical design tools, software, and publish design guidelines, for engineers to lay and keep cryogenic pipelines stable on the seabed. Transferring liquefied natural gas between floating tankers and onshore plants conventionally relies on a pipeline on a trestle system. As an alternative, novel subsea cryogenic pipelines are being considered. By ensuring the stability of subsea cryogeni ....Cryogenic pipelines to replace trestle for liquefied gas transfer terminals. This project aims to develop geotechnical design tools, software, and publish design guidelines, for engineers to lay and keep cryogenic pipelines stable on the seabed. Transferring liquefied natural gas between floating tankers and onshore plants conventionally relies on a pipeline on a trestle system. As an alternative, novel subsea cryogenic pipelines are being considered. By ensuring the stability of subsea cryogenic pipelines laid directly on the seabed, this project will provide significant benefits to Australia’s liquefied natural gas trade by unlocking substantial cost savings, and making this key export industry more competitive.Read moreRead less
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Interactions Between RAGE And The Type 1 Angiotensin Receptor Determine The Pro-atherosclerotic Actions Of Angiotensin II
Funder
National Health and Medical Research Council
Funding Amount
$521,956.00
Summary
Heart attacks and strokes are a major cause of death and disability in Australians. Activation of the renin angiotensin system plays a key role in the development and progression of atherosclerosis, the process that leads to narrowing and obstruction of arteries. In preliminary data we have found a way to block these pathways without affecting the control of blood pressure. We believe that interventions based on these data will be important for the prevention and treatment of heart disease.