Epilepsy is one of the most common chronic neurological disorders; it affects 1% of the world’s population, yet about 1 in 3 patients fail to achieve seizure control with current drugs. We will improve the properties of small molecules (drugs) that specifically target the GTPase activity of the enzyme dynamin, to reduce seizure effect in the brain by a novel mechanism. We will optimize and pre-clinically test these future chemical entities as potential anti-epileptic drugs.
Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Organisational Motivation as a Predictor of Benefits from the Adoption of Information Technology. IOS are becoming increasingly important for organisations to remain competitive in a global marketplace. By using organisational motivations to better understand how to design and structure the processes for IOS implementation and set more realistic expectation, Australian organisations will be able to develop more effective, evidence-based methods for IOS implementation. The theory being tested is ....Organisational Motivation as a Predictor of Benefits from the Adoption of Information Technology. IOS are becoming increasingly important for organisations to remain competitive in a global marketplace. By using organisational motivations to better understand how to design and structure the processes for IOS implementation and set more realistic expectation, Australian organisations will be able to develop more effective, evidence-based methods for IOS implementation. The theory being tested is an original contribution in a growing area of information technology research. The data and rigorously tested research protocols developed will enhance Australia'a research standing, contribute to university teaching and researcher training, and improve the effectiveness and efficiency of the Australian information technology industry. Read moreRead less
In 2013 there were ~200 million clinical cases of malaria, causing ~600,000 deaths. All antimalarial drugs are now associated with malaria parasite resistance. Thus, new therapies are urgently needed, including new drugs to prevent this disease. We have made the exciting discovery that an existing antimalarial drug can kill malaria parasites in a unique, previously unknown, manner. Here, we will investigate how this occurs and develop new drug candidates for malaria prevention.
Structure-based Design Of Novel Therapeutics For Multi-drug Resistant Neisseria Gonorrhoeae
Funder
National Health and Medical Research Council
Funding Amount
$669,148.00
Summary
Multiple drug resistance (MDR) in bacteria represents one of the most intractable problems facing modern medicine. The recent superbug, MDR-Neisseria gonorrhoeae (MDR-Ng), causes the sexually transmitted infection gonorrhoeae. A multi disciplinary team with expertise in structural biology, medicinal chemistry and bacteriology will establish a comprehensive knowledge base aimed at developing new antibiotics to treat MDR-Ng by targeting a bacterial protein virulence factor.
Development Of Small Molecule Modulators Of Apoptosis
Funder
National Health and Medical Research Council
Funding Amount
$621,558.00
Summary
Cancers rely on the deregulation of key cellular pathways. Along with biological and genetic tools, small molecules are powerful probes to understand these mechanisms. During the course of this research program, we will develop new and drug-like molecules that reinstate the cell death process to combat malignancies. This research will bring important advances for potential chemotherapies and create probes to better understand the biology of programmed cell death processes.
Privacy-Preserving Remote Access to Health Information Infrastructure in Ubiquitous Computing Environments. The project's benefits can be summarised as follows. (a) The project will provide new solutions that enable remote access to health-care data in a secure and privacy-preserving manner. (b) This will improve health care services in northern metropolitan Melbourne, and provide shorter medical response time, which is particularly important in emergency scenarios. (c) It will exemplify advance ....Privacy-Preserving Remote Access to Health Information Infrastructure in Ubiquitous Computing Environments. The project's benefits can be summarised as follows. (a) The project will provide new solutions that enable remote access to health-care data in a secure and privacy-preserving manner. (b) This will improve health care services in northern metropolitan Melbourne, and provide shorter medical response time, which is particularly important in emergency scenarios. (c) It will exemplify advanced IT support for health care, which can be utilised by other providers. (d) The project will make a direct link between IT research and its industrial application. (e) The project will also give the opportunity to a postdoctoral researcher and PhD students to perform leading edge research on privacy protection of information in an industrial environment.Read moreRead less
A Model for IT Security Outsourcing of Critical Services. IT security outsourcing is the establishment of a contractual relationship with an outside vendor to assume responsibility for one or more security functions. The decision-making process associated with outsourcing security is complex. To improve the effectiveness of the decision-making process a conceptual model that integrates security benefits, costs and their respective performance measures will be developed. This model will support m ....A Model for IT Security Outsourcing of Critical Services. IT security outsourcing is the establishment of a contractual relationship with an outside vendor to assume responsibility for one or more security functions. The decision-making process associated with outsourcing security is complex. To improve the effectiveness of the decision-making process a conceptual model that integrates security benefits, costs and their respective performance measures will be developed. This model will support management in their aim of overseeing IT security effectively. The research will make a valuable contribution towards determining the impact of IT security outsourcing within Australia.Read moreRead less
Developing Novel Anti-cancer Agens By High Throughput Chemical Screens For Small Molcules That Modulate The Pro-survival
Funder
National Health and Medical Research Council
Funding Amount
$125,000.00
Summary
Cancer is the second commonest cause of deaths in our community. Unfortunately, treatment often fails or causes unwanted side effects. This proposal seeks to discover and develop a novel class of anti-cancer drugs that act by directly activating programmed cell death (apoptosis). The Bcl-2 proteins are key regulators of cell death and by exploiting knowledge about these prime targets for cancer therapy, we aim to discover drugs that are potentially of considerable medical and commercial value.