Centre Of Research Excellence In Medicines Intelligence
Funder
National Health and Medical Research Council
Funding Amount
$2,500,000.00
Summary
The NHMRC Centre of Research Excellence in Medicines Intelligence is a co-ordinated research program that will accelerate the development and translation of evidence on prescribed medicines use and outcomes for regulators and payers. The CRE is perfectly placed to embrace the national ‘call to action’ from the Health Minister's recent announcement to establish Quality Use of Medicine Safety as a National Health Priority.
Activation Of BMP4 Signalling To Inhibit Breast Cancer Metastasis
Funder
National Health and Medical Research Council
Funding Amount
$748,742.00
Summary
The spread of cancer cells to other organs is a common cause of breast cancer-related death in women. Current therapies for advanced breast cancer are often palliative since the secondary tumours become resistant to the chemotherapy. Here, we are using preclinical models of advanced breast cancer to develop a treatment that should be effective in patients with secondary tumours and should reduce the risk of dying of this disease.
Developing culturally relevant social marketing interventions to increase blood donation amongst migrant communities: the case of African migrants. To increase blood donation amongst migrant communities, a culturally relevant intervention will be developed and tested. This will ensure migrants are integrated into Australian society and that blood supplies are sustainable, by overcoming migrants’ potential lack of understanding of local blood donation processes and perceptions that they may be ex ....Developing culturally relevant social marketing interventions to increase blood donation amongst migrant communities: the case of African migrants. To increase blood donation amongst migrant communities, a culturally relevant intervention will be developed and tested. This will ensure migrants are integrated into Australian society and that blood supplies are sustainable, by overcoming migrants’ potential lack of understanding of local blood donation processes and perceptions that they may be excluded.Read moreRead less
Multidrug Resistance Protein 1 Inhibitors To Sensitise Cancers To Chemotherapy
Funder
National Health and Medical Research Council
Funding Amount
$840,166.00
Summary
Multidrug resistance protein 1 (MRP1) is often present at high levels in cancer cells, where it pumps chemotherapy drugs back out, causing drug resistance. Inhibitors that block MRP1 would increase the effectiveness of chemotherapy. We have developed MRP1 inhibitors with promising activity in cancer cells and mouse tumours and will now develop these inhibitors for clinical application and commercialisation.
Industrial Transformation Training Centres - Grant ID: IC210100040
Funder
Australian Research Council
Funding Amount
$4,997,903.00
Summary
ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence- ....ARC Training Centre for Facilitated Advancement of Australia's Bioactives (FAAB). The Centre for Facilitated Advancement of Australia's Bioactives (FAAB) will transform the rapidly growing bioactive ingredients sector. It will apply advanced analytical methods to molecular characterisation of bioactive products derived from foods, food-waste, and cell-based biotechnologies. FAAB will determine modes of action for bioactives with potential lifestyle and nutritional benefits allowing for evidence-informed decision-making, and regulatory framework development. FAAB graduates will lead and deliver future national self-reliance to the Australian bioactives sector, increasing diversification and international competitiveness and development of regulation in a growing market. Read moreRead less
Australian cultural and creative activity: A population and hotspot analysis. This project aims to grasp the contemporary dynamics of cultural and creative activity in Australia. It represents a major innovation, bringing together population-level and comparative studies of local cultural and creative activity. The comprehensive project will advance the integration of quantitative and qualitative research strategies, painting a complete national picture, while also exploring the factors that are ....Australian cultural and creative activity: A population and hotspot analysis. This project aims to grasp the contemporary dynamics of cultural and creative activity in Australia. It represents a major innovation, bringing together population-level and comparative studies of local cultural and creative activity. The comprehensive project will advance the integration of quantitative and qualitative research strategies, painting a complete national picture, while also exploring the factors that are producing local and regional creative hotspots. The project will deliver outputs such as reports and forums that are framed in close collaboration with partners in order to deliver outcomes such as better-targeted policy and program initiatives. This will provide national cultural and policy benefits from placing the creative sector in front of policy makers as a vital contributor to high growth, labour-intensive economic activity in the context of the Australian economy in transition.Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH120100021
Funder
Australian Research Council
Funding Amount
$2,500,000.00
Summary
Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainabil ....Pathways to market: transforming food industry futures through improved sensing, provenance and choice. Pathways to market: transforming food industry futures through improved sensing, provenance and choice. This Research Hub aims to transform the Australian food industry by demonstrating how new knowledge on food production and consumption generated through novel sensing technologies and advanced modelling techniques can be implemented in smart applications to power competitiveness, sustainability and innovation in food value chains.Read moreRead less
Making policy reform work: a comparative analysis of social procurement . This project aims to clarify the institutional and cross-sectoral conditions needed for successful implementation of emerging social procurement policy reforms; these seek through public spending to increase employment and business opportunities for people experiencing social exclusion. Via a mixed-methods comparative study in the leading jurisdictions of Victoria and Scotland, the project will extend scholarly knowledge o ....Making policy reform work: a comparative analysis of social procurement . This project aims to clarify the institutional and cross-sectoral conditions needed for successful implementation of emerging social procurement policy reforms; these seek through public spending to increase employment and business opportunities for people experiencing social exclusion. Via a mixed-methods comparative study in the leading jurisdictions of Victoria and Scotland, the project will extend scholarly knowledge of implementing policy reforms that rely on government and non-government actors working together in new ways, and practical understanding of what is needed to realise social procurement policy goals. This will contribute to effective public expenditure and ultimately help redress the societal consequences of exclusion.Read moreRead less
ADAM Metalloprotease Inhibition For Treatment Of Colorectal Cancer
Funder
National Health and Medical Research Council
Funding Amount
$770,925.00
Summary
Colorectal cancer (CRC) causes over 4000 deaths/year, typically from developing drug resistance and spreading to other organs (metastasis). These processes involve tumour cells called cancer stem cells (CSCs), which rely on specific cell surface proteins for survival and function. We are developing antibodies against one of these type of proteins, to test in mouse models of CRC. These already show promise in targeting CSCs and inhibiting drug-resistance and metastasis in mice.
Physical musicality: Optimising lived experience among older adults . The aim of this project is to investigate how music-supported exercise, called physical musicality (PM), can promote wellbeing, quality of life, and cognitive-motor function in older adults, beyond the benefits of exercise or music listening alone. To achieve this aim, we will (a) conduct randomised control trials on PM programs; (b) isolate the ingredients and mechanisms underlying the benefits of PM; and (c) design culturall ....Physical musicality: Optimising lived experience among older adults . The aim of this project is to investigate how music-supported exercise, called physical musicality (PM), can promote wellbeing, quality of life, and cognitive-motor function in older adults, beyond the benefits of exercise or music listening alone. To achieve this aim, we will (a) conduct randomised control trials on PM programs; (b) isolate the ingredients and mechanisms underlying the benefits of PM; and (c) design culturally appropriate programs that optimise wellbeing and cognitive-motor function for older adults. Our research will reveal simple, non-medical steps that all adults of advancing age can take to maintain their wellbeing and cognitive functions so they can lead productive and successful lives into older age. Read moreRead less