Characterisation of tumour variants of Devil Facial Tumour Disease. This project will take a new approach to cancer research by studying the evolution of Devil Facial Tumour Disease. The results will directly contribute to the conservation management of the Tasmanian devil, as well as generating new information on tumour growth, metastasis and emergence of resistance.
Discovery Early Career Researcher Award - Grant ID: DE190101069
Funder
Australian Research Council
Funding Amount
$390,000.00
Summary
Adaptation and diversification of the first peoples of Sahul. This project aims to further advance work on the genetic history of Indigenous Australians and Papuans that has revealed that Aboriginal Australians have inhabited a variety of diverse and challenging environments for approximately 50,000 years. Using novel techniques for extraction of human DNA from soil and the use of cutting-edge graph-based methods, hundreds of Indigenous Australian and Papuan genomes will be analysed. This projec ....Adaptation and diversification of the first peoples of Sahul. This project aims to further advance work on the genetic history of Indigenous Australians and Papuans that has revealed that Aboriginal Australians have inhabited a variety of diverse and challenging environments for approximately 50,000 years. Using novel techniques for extraction of human DNA from soil and the use of cutting-edge graph-based methods, hundreds of Indigenous Australian and Papuan genomes will be analysed. This project expects to generate new knowledge by filling in the gaps in the Australian genetic record via ancient human DNA from sediments. Expected outcomes from this project are producing a detailed picture of genomic adaptation in Indigenous Australians and Papuans and creating a comprehensive genetic history of the First Peoples of Sahul.Read moreRead less
The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare function ....The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare functional, gene expression and methylation status after such challenges in intact and methylase deleted animals to determine how vital this process really is. This work has major implications for our understanding of epigenetics, and the ways in which genes interact with the environment especially in times of change.Read moreRead less
Transcriptome sequencing and functional characterisation of craniate non-visual sensory systems and their adaptation to diverse light environments. Light detection (photoreception) is critical to species survival. It is not limited to vision, but also serves to set biological rhythms. In mammals, all photoreception is thought to occur solely through the eye, but in non-mammals many other tissues directly monitor light levels. However, the signalling cascades and functional roles of these non-vis ....Transcriptome sequencing and functional characterisation of craniate non-visual sensory systems and their adaptation to diverse light environments. Light detection (photoreception) is critical to species survival. It is not limited to vision, but also serves to set biological rhythms. In mammals, all photoreception is thought to occur solely through the eye, but in non-mammals many other tissues directly monitor light levels. However, the signalling cascades and functional roles of these non-visual pathways are largely unknown. This project will use high-throughput sequencing technologies and functional analyses to trace the origin and function of different irradiance detection systems in each main craniate class. By comparing species from diverse photic habitats, the influence of light as a substrate for adaptation will be investigated.Read moreRead less