Impact Of Co-morbidities On Screening, Diagnosis, Treatment And Survival Of Cervical Cancer Amongst Australian Indigenous And Non-Indigenous Women: 1997-2009
Funder
National Health and Medical Research Council
Funding Amount
$98,236.00
Summary
Indigenous women are more likely than non-Indigenous Australian women to be diagnosed with cervical cancer and are less likely to survive it. This study will investigate the impact of co-exisiting chronic diseases (co-morbidities) on cervical cancer screening, diagnosis, treatment and survival outcomes for Indigenous compared to non-Indigenous women. Results from this study will assist in directing future public health initiatives that aim to improve outcomes for women with cervical cancer.
Estimating The Burden Of Group A Streptococcal Diseases In Victoria
Funder
National Health and Medical Research Council
Funding Amount
$386,760.00
Summary
Despite the considerable advances in the diagnosis and treatment of group A streptococcal (GAS) diseases made during the last century, the impressive spectrum of infections caused by this organism continues to have a significant impact in developed countries. This spectrum includes diseases that are mild but common (e.g. sore throat, skin sores), rare but very severe (e.g. bloodstream infections, flesh-eating bacteria) and those that are more common in developing countries and the Aboriginal pop ....Despite the considerable advances in the diagnosis and treatment of group A streptococcal (GAS) diseases made during the last century, the impressive spectrum of infections caused by this organism continues to have a significant impact in developed countries. This spectrum includes diseases that are mild but common (e.g. sore throat, skin sores), rare but very severe (e.g. bloodstream infections, flesh-eating bacteria) and those that are more common in developing countries and the Aboriginal population (e.g. rheumatic fever, kidney disease). Streptococcal sore throat remains one of the most common childhood infections, and severe group A streptococcal diseases are thought to be increasing in incidence in Australia. Yet, there are no accurate data on the incidence and costs of these or other GAS diseases in non-Aboriginal Australians, or in most other populations around the world. It is becoming more urgent to collect this data as numerous vaccine candidates are entering human trials, new approaches to the treatment of sore throat are emerging, and new strategies to treat and control the spread of severe disease are being developed. We propose a comprehensive strategy to measure the incidence, prevalence and costs of each group of GAS diseases. We will follow a group of families for 12 months to detect cases of GAS sore throat and skin sores and measure the impact on the family. We will survey children in schools to estimate the prevalence of skin sores. We will check hospital records to calculate the number of cases of rheumatic fever and kidney disease. And we will maintain surveillance for severe diseases by checking hospital and laboratory records. We will also check to see if family members of people with severe disease have the GAS bacterium in their throats. We will then compile these data into a comprehensive estimate of the burden of disease in Victoria, and estimate the cost-effectiveness of different treatment and prevention strategies.Read moreRead less
Strategies to reduce risk of heat induced illness during intermittent, high intensity activity in a tropical environment. Regular intermittent, high intensity physical activity (IHIA) affords protection against modern life-style diseases (type II diabetes, coronary heart disease and some cancers) but when conducted in the tropics, exposes persons to the risk of dehydration, heat cramps, hypotension, heat syncope, heat exhaustion and heat stroke. Australia has rapid population growth in the tropi ....Strategies to reduce risk of heat induced illness during intermittent, high intensity activity in a tropical environment. Regular intermittent, high intensity physical activity (IHIA) affords protection against modern life-style diseases (type II diabetes, coronary heart disease and some cancers) but when conducted in the tropics, exposes persons to the risk of dehydration, heat cramps, hypotension, heat syncope, heat exhaustion and heat stroke. Australia has rapid population growth in the tropics and key sporting fixtures have moved to the region. We have set up the research capability and must now move on a range of IHIA in sport, workplaces, armed and emergency services to provide strategies to reduce the risk of heat induced illness in a tropical environment.Read moreRead less
CENTRE OF RESEARCH EXCELLENCE TO REDUCE INEQUALITY IN HEART DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$2,607,253.00
Summary
There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health ....There is increasing recognition of a societal responsibility to provide effective and sustainable health care to the entire population and not just to selected parts. Indigenous and regional Australians are most affected by Australia's biggest killer - heart disease. In response, the CRE to Reduce Inequality in Heart Disease, is a national collaboration of researchers from a range of health disciplines. Together they aim to address this problem by developing sustainable and cost-effective health care services.Read moreRead less
Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable ....Gambling-related harm in Northern Australia: A Geographic Information Systems (GIS)-based spatiotemporal analysis of venue catchments. There is growing national concern about the impact of electronic gaming (poker) machines yet little is known about the effects of this gambling in rural and remote areas of Australia. We will develop a database to define the geographic distribution of gambling impacts, the nature of high-risk venues, and the characteristics, both spatial and social, of vulnerable communities. This will enable the design of much needed harm minimisation strategies and will provide regulatory bodies with insights into the capacity of local communities to absorb the impact of electronic gaming machine venues.Read moreRead less
Modelling Payments for Environmental Services on Indigenous held lands. Payments for environmental services (PES) such as fire management have potential to provide employment to indigenous people managing land that has previously been thought to hold no commercial value. In so doing it could transform the economies of the very remote parts of Australia where indigenous people live. For these schemes to work, however, greater understanding is required not only of the willingness of society to pay ....Modelling Payments for Environmental Services on Indigenous held lands. Payments for environmental services (PES) such as fire management have potential to provide employment to indigenous people managing land that has previously been thought to hold no commercial value. In so doing it could transform the economies of the very remote parts of Australia where indigenous people live. For these schemes to work, however, greater understanding is required not only of the willingness of society to pay for environmental services in northern Australia but also of the perceptions of the indigenous people who are providing these services. Choice modelling can (1) quantify values of different environmental services in different sectors of society and (2) help allocate the payments for environmental services efficiently.Read moreRead less
Analysis of legislation and policies affecting the development of Indigenous wildlife-based enterprises. Entrepreneurial enterprise development by Indigenous people in remote regions is being encouraged as part of government policy to move people off welfare and into work. Indigenous knowledge of wildlife makes it a logical source of wealth generation but a range of legal and policy constraints add to substantial existing social and logistical problems. An understanding of the legal processes in ....Analysis of legislation and policies affecting the development of Indigenous wildlife-based enterprises. Entrepreneurial enterprise development by Indigenous people in remote regions is being encouraged as part of government policy to move people off welfare and into work. Indigenous knowledge of wildlife makes it a logical source of wealth generation but a range of legal and policy constraints add to substantial existing social and logistical problems. An understanding of the legal processes involved in establishing and maintaining sustainable and ongoing wildlife-based enterprises will improve their chances of success, and will also offer the opportunity to change regulatory frameworks to ensure consistency, remove contradictions and encourage workforce participation. The research will have national and international implications.Read moreRead less
Developing Ecosystem Services Economies for northern Australia. The project aims to advance economic opportunities for Indigenous communities across Northern Australia by developing culturally appropriate ecosystem services economies. The project will offer new alternatives for collectively addressing chronic Indigenous socio-economic issues and pressing environmental issues. Expected outcomes include a co-developed ecosystem services economies business model with a toolkit, involving Indigenous ....Developing Ecosystem Services Economies for northern Australia. The project aims to advance economic opportunities for Indigenous communities across Northern Australia by developing culturally appropriate ecosystem services economies. The project will offer new alternatives for collectively addressing chronic Indigenous socio-economic issues and pressing environmental issues. Expected outcomes include a co-developed ecosystem services economies business model with a toolkit, involving Indigenous and business stakeholders, for establishing innovative enterprises across northern Australia. Key benefits include new ecosystem services-based enterprises; sustainable land sector development; jobs in remote locations; improved well-being of Indigenous peoples; and better environmental management. Read moreRead less
About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock a ....About time; a new biology for the mineralocorticoid receptor . Temporal control of cell function aligns biological pathways with environmental cues and is critical for optimal heath in mammals. This project will shed light on how a hormone receptor, the MR, modulates time keeping of biological clock time in cells. We will bring together cutting edge genetic modals and bioinformatic approaches with a unique set of research models to define the interaction between the MR and the circadian clock and its role in the normal biology of the heart. New data will significantly enhance our understanding of the biology of MR and cortisol for the circadian time keeping function in peripheral tissues, and gain a clearer understand how our heart cells adapt to environmental circadian disruptors such as shift work. Read moreRead less
Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of th ....Threats to the water quality and ecosystem of Coffin Bay, South Australia. Coffin Bay (South Australia) is experiencing worsening environmental conditions despite its major economic and ecological importance. Research is needed to understand the cause of this decline, particularly in light of a recent bacterial outbreak that impacted the aquaculture industry. This multidisciplinary project aims to deliver world-leading scientific advice based on novel field techniques and innovative models of this complex inverse estuary system and its surrounding catchment. The new understanding of the sources, fluxes and fate of nutrients within the bay and the surrounding catchment, arising from this project, is expected to benefit management decision-making and establish a new standard in estuarine water quality investigation.Read moreRead less