Evaluating The Genetic Contribution To Rheumatic Heart Disease Pathogenesis In Australian Aboriginal And Torres Strait Islander Communities
Funder
National Health and Medical Research Council
Funding Amount
$1,782,074.00
Summary
Rheumatic heart disease is highly prevalent in Aboriginal people in Australia and leads to early cardiac disease. Despite decades of research, the underlying genetic mechanisms for why it occurs are not well understood. We are conducting a genetic study to better understand why some people are susceptible to RHD and others are not. The study will involve substantial Aboriginal leadership and consultation and will be a model for the conduct of genetic studies in Aboriginal populations.
Estimating the potential supply of environmental services by landholders. Wilderness, natural habitats, biodiversity and other aspects of natural capital and their associated ecosystem services are in decline. Increasing scarcity is driving a surge in interest in these services and their value. It potentially provides opportunities for landholders to be generating income from environmental services provision, and lessens dependency on livestock, crop and fibre production. But how realistic are t ....Estimating the potential supply of environmental services by landholders. Wilderness, natural habitats, biodiversity and other aspects of natural capital and their associated ecosystem services are in decline. Increasing scarcity is driving a surge in interest in these services and their value. It potentially provides opportunities for landholders to be generating income from environmental services provision, and lessens dependency on livestock, crop and fibre production. But how realistic are these prospects? A critical aspect of potential markets for environmental services is their supply. This project examines the supply side of environmental services by exploring determinants of ability and willingness of landholders to provide these services.Read moreRead less
Evaluating the impact of Indigenous preferential procurement programs. This project aims to conduct a multi-disciplinary, multi-method evaluation of the implementation and impacts of Indigenous preferential procurement programs (IPPPs) on Indigenous businesses, Indigenous communities, procurers’ operations and outcomes. Bringing together researchers in partnership with corporate and government procurers, Indigenous data custodians and the Australian Bureau of Statistics we aim to produce a signi ....Evaluating the impact of Indigenous preferential procurement programs. This project aims to conduct a multi-disciplinary, multi-method evaluation of the implementation and impacts of Indigenous preferential procurement programs (IPPPs) on Indigenous businesses, Indigenous communities, procurers’ operations and outcomes. Bringing together researchers in partnership with corporate and government procurers, Indigenous data custodians and the Australian Bureau of Statistics we aim to produce a significant national program evaluation of IPPPs and the impact at the community level. The project aims to highlight ways in which IPPPs can be [re]designed to reduce implementation friction, facilitate access and participation among Indigenous businesses and help guarantee positive effects on Indigenous communities.Read moreRead less
Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of ....Heat stress in the workplace: health burden and labour productivity loss. This project aims to estimate the economic loss of workplace heat exposure in Australia. The project will investigate the health services costs of occupational heat-related illnesses/injuries, explore the labour productivity loss and its costs resulting from heat stress at work, and estimate the benefits from a generic heat warning intervention for workplace heat prevention. Outcomes are expected to provide an overview of national economic implications at present and in the future from effective heat stress control, assist the development of work place heat policies, and inform resource allocation to make Australian workplaces well prepared for likely increasing extremely hot weather.Read moreRead less
Modelling Payments for Environmental Services on Indigenous held lands. Payments for environmental services (PES) such as fire management have potential to provide employment to indigenous people managing land that has previously been thought to hold no commercial value. In so doing it could transform the economies of the very remote parts of Australia where indigenous people live. For these schemes to work, however, greater understanding is required not only of the willingness of society to pay ....Modelling Payments for Environmental Services on Indigenous held lands. Payments for environmental services (PES) such as fire management have potential to provide employment to indigenous people managing land that has previously been thought to hold no commercial value. In so doing it could transform the economies of the very remote parts of Australia where indigenous people live. For these schemes to work, however, greater understanding is required not only of the willingness of society to pay for environmental services in northern Australia but also of the perceptions of the indigenous people who are providing these services. Choice modelling can (1) quantify values of different environmental services in different sectors of society and (2) help allocate the payments for environmental services efficiently.Read moreRead less
Demographic change, ageing and the workforce: An integrated model to inform workforce development and planning in Australia. This project will greatly extend our understanding of the impact of demographic change and ageing on the workforce. It will develop a conceptual framework to strategically inform workforce development and a workforce planning model to assist Australian workplaces to respond to the challenge of demographic change and ageing. The need to develop a better understanding of, an ....Demographic change, ageing and the workforce: An integrated model to inform workforce development and planning in Australia. This project will greatly extend our understanding of the impact of demographic change and ageing on the workforce. It will develop a conceptual framework to strategically inform workforce development and a workforce planning model to assist Australian workplaces to respond to the challenge of demographic change and ageing. The need to develop a better understanding of, and respond to, the implications of demographic change and ageing for workforce development in Australia has been recognised nationally through the National Strategy for Ageing and is of direct relevance to the ARC's national research priority Ageing Well, Ageing Productively. Read moreRead less
Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We ....Engineering and expression of recombinant antibodies that interact with plant pathogenic phytoplasma membrane proteins - a model for phytoplasma disease management. . In Australia phytoplasmas are associated with serious diseases including papaya dieback and strawberry lethal yellows. Phytoplasmas cannot be cultured so there is a paucity of knowledge at the genomic level. We have identified the ABC Transporter and FtsH genes and expressed these phytoplasma membrane proteins (MP) in E. coli . We will generate antibody fragments that bind these MP and express them in tomato. We will analyse antibody expression in tomato and study their association with the phytoplasma membrane. Transgenic plants will be inoculated with phytoplasma and monitored for resistance. This work represents a major step towards engineering resistance to phytoplasmas.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0989147
Funder
Australian Research Council
Funding Amount
$950,000.00
Summary
Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to bi ....Advanced high throughput genomics facility for biological, medical, agricultural, environmental and evolutionary research. Infrastructure requested will expand the capacity of researchers in NSW/NT to undertake environmental, medical and evolutionary studies using state-of-the-art technologies based on the recent advances in DNA sequencing analyses. It will ensure the retention of leading researchers in the exciting areas of genomics and Systems Biology and make a significant contribution to biomolecular research in medicine, agriculture and environmental biology, thereby providing major benefits to the wider community. The application will enhance existing genomic technologies by substantially increasing the scope of experiments that can be performed leading to important advances in gene discovery.Read moreRead less
Natural resource management and enterprise development: can they improve Indigenous livelihoods? High on the Australian agenda is the removal of disadvantage faced by Indigenous groups and the sustainable use of biodiversity on Indigenous land. In terms of Eastern Indonesia, the Australian agenda relates to poverty eradication, with fewer threats to Australian borders in terms of illegal fishing and migration. This project provides fundamental knowledge on household resource use patterns, and th ....Natural resource management and enterprise development: can they improve Indigenous livelihoods? High on the Australian agenda is the removal of disadvantage faced by Indigenous groups and the sustainable use of biodiversity on Indigenous land. In terms of Eastern Indonesia, the Australian agenda relates to poverty eradication, with fewer threats to Australian borders in terms of illegal fishing and migration. This project provides fundamental knowledge on household resource use patterns, and the constraints and opportunities for natural resource activities, as a step towards identifying ways in which natural resources can be mobilised to improve livelihoods. Read moreRead less
Increasing the effectiveness of Australian threatened bird conservation. Conservation of threatened species is expensive and success rare or fleeting. Analysis of nearly three decades of threatened species conservation management, and an understanding of the complex of factors that affect success, will help increase the efficiency of conservation planning. Improved understanding of the biological, economic, social and institutional environment within which conservation management occurs will hel ....Increasing the effectiveness of Australian threatened bird conservation. Conservation of threatened species is expensive and success rare or fleeting. Analysis of nearly three decades of threatened species conservation management, and an understanding of the complex of factors that affect success, will help increase the efficiency of conservation planning. Improved understanding of the biological, economic, social and institutional environment within which conservation management occurs will help managers allocate resources appropriately. This type of analysis has never been done for an entire fauna at a continental scale and will have global significance. Furthermore the networks to which the investigators are connected will ensure that the results can be rapidly translated into practice.Read moreRead less