The Future of Australian Mineral Exports. Australia is among the world's largest exporters of steelmaking raw materials, specifically iron ore, coking coal and manganese. This project will develop an integrated econometric model of the global steel industry to forecast future trends in global steel production and the associated demand for raw materials. The results of this research will not only assist Australian mineral exporters in achieving better outcomes in annual pricing negotiations by im ....The Future of Australian Mineral Exports. Australia is among the world's largest exporters of steelmaking raw materials, specifically iron ore, coking coal and manganese. This project will develop an integrated econometric model of the global steel industry to forecast future trends in global steel production and the associated demand for raw materials. The results of this research will not only assist Australian mineral exporters in achieving better outcomes in annual pricing negotiations by improving market knowledge, but also help focus their longer term marketing strategies. The extensive global mine database to be assembled as part of the network flow component of this model will also allow Australian mineral exporters to assess their competitive position relative to foreign producers.Read moreRead less
Reforming the procurement of construction and financing of Australian infrastructure: Advancing capacity, competition and investment. The project will significantly assist Federal and State governments in delivering value for money in the provision of a substantial infrastructure pipeline. The project will promote the transformation of the domestic construction industry in Australia, in terms of saving unnecessary transaction costs, promoting productivity, advancing training and accessing the wo ....Reforming the procurement of construction and financing of Australian infrastructure: Advancing capacity, competition and investment. The project will significantly assist Federal and State governments in delivering value for money in the provision of a substantial infrastructure pipeline. The project will promote the transformation of the domestic construction industry in Australia, in terms of saving unnecessary transaction costs, promoting productivity, advancing training and accessing the world's best knowledge and skills. In total, the project will help ensure that new infrastructure contributes to Australia's economic growth and counters inflationary pressures. Finally, the transferable knowledge outcomes of this project have potential to capture global attention and promote Australia as a leading nation in the provision of infrastructure.Read moreRead less
Conceptualizing and Measuring Regional Endogenous Growth: A Collaborative International Comparative Investigation. Policy for regional economic development in Australia is placing more emphasis on facilitating regional self-help. For the first time this project will provide an actual measure of regional endogenous performance. It identifies those features of regional economies and local populations are most important in explaining differences in the performance of regions, and it shows how inst ....Conceptualizing and Measuring Regional Endogenous Growth: A Collaborative International Comparative Investigation. Policy for regional economic development in Australia is placing more emphasis on facilitating regional self-help. For the first time this project will provide an actual measure of regional endogenous performance. It identifies those features of regional economies and local populations are most important in explaining differences in the performance of regions, and it shows how institutional arrangements and leadership can enhance or detract from regional development performance. This will help public agencies formulate better policies and mechanisms to help regions maximise their capacities to achieve enhanced endogenous growth. International comparative studies provide wider significance for policy formulation in regional development.Read moreRead less
New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R& ....New Techniques for Structural Biology and Directed Molecular Evolution. This PhD program will equip an Australian graduate with advanced training in techniques in molecular genetics and protein chemistry that are currently in high demand by the biotechnology industry, and also provide him/her with direct experience of an industrial R&D laboratory environment. Moreover, it will establish a basis for further collaboration between a leading University-based research laboratory and an established R&D company that will lead to development of new techniques for use in biotechnology in Australia and overseas.Read moreRead less
Market Model of Implied Volatility. The outcomes of the project will constitute a new methodology with a wide range of tools to handle the market uncertainties with practical applications in the finance industry. Consequently, the benefits of this project to the nation include enhancing its scientific standing in the international community, the training of Australian researchers in forefront methods of modelling of complex stochastic systems and the benefits resulting from its commercially rele ....Market Model of Implied Volatility. The outcomes of the project will constitute a new methodology with a wide range of tools to handle the market uncertainties with practical applications in the finance industry. Consequently, the benefits of this project to the nation include enhancing its scientific standing in the international community, the training of Australian researchers in forefront methods of modelling of complex stochastic systems and the benefits resulting from its commercially relevant elements. Read moreRead less
In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function ....In vitro expression and crystallization of proteins from the thermohalophile, Halothermothrix orenii. The project proposal is to develop enabling state-of-the-art protein technologies for biotechnology. We will for the first time develop a rapid and high throughput technique for the expression, purification and crystallisation of proteins from the extreme thermohalophile, Halothermothrix orenii. This important break through in protein technology will assist in determining structure and function relationships of thermohalophilic proteins. It is expected that such an understanding together with comparative bioinformatics will assist researchers to develop "designer proteins" with improved functions for different uses in biotechnology. It is also expected that this technology will be amenable for use with other thermohalophilic microbes.Read moreRead less
Recovery and characterization of monooxygenases for biocatalysis and bioremediation through development of novel DNA- and protein-based technology. Australia contains hundreds of sites contaminated with toxic waste and judged to pose significant risk of harm to the public. This project will identify enzymes and organisms capable of remediating such contaminated sites by natural processes. It will also result in training of persons and development of techniques that will contribute to making bi ....Recovery and characterization of monooxygenases for biocatalysis and bioremediation through development of novel DNA- and protein-based technology. Australia contains hundreds of sites contaminated with toxic waste and judged to pose significant risk of harm to the public. This project will identify enzymes and organisms capable of remediating such contaminated sites by natural processes. It will also result in training of persons and development of techniques that will contribute to making bioremediation an environmentally sustainable and cost-effective technology. The environmental proteomics strategy is a frontier technology, expected to have broad applications in health, food science and the environment. Our development of this technology will create a wide range of opportunities for Australian scientists and companies.Read moreRead less
Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not re ....Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease. Chronic inflammatory diseases, including rheumatoid arthritis and inflammatory bowel disease, affect millions of people leading to considerable suffering, economic loss and premature death. Anti-TNF treatments have recently shown success in the treatment of rheumatoid arthritis, inflammatory bowel disease and other conditions, however, a substantial number of patients (~50%) do not respond to the current TNF treatments. Improved anti-TNF strategies would provide enhanced health outcomes and welcome relief to many Australians. In addition, the economic benefit of the TNF market is very substantial. Therefore the potential impact of this research is very high both for health care and economical potential.Read moreRead less
Analysis of the financial circumstances of local governments, to assess viability, and improve planning, resource allocation and accountability. The project aims to (a) develop a framework for improved reporting by local government, through a critical analysis of AAS 27 and extant legislative guidelines; (b) assess the financial viability of existing local government units; (c) identify units which may be candidates for amalgamation. Outcomes will include (i) proposals to enhance NSW's pioneer ....Analysis of the financial circumstances of local governments, to assess viability, and improve planning, resource allocation and accountability. The project aims to (a) develop a framework for improved reporting by local government, through a critical analysis of AAS 27 and extant legislative guidelines; (b) assess the financial viability of existing local government units; (c) identify units which may be candidates for amalgamation. Outcomes will include (i) proposals to enhance NSW's pioneering provisions for infrastructure reporting, contained in the NSW Local Government Act 1993 and accompanying guidelines; (ii) a pioneering assessment of the financial circumstances of local government units, having regard to the projected costs of upgrading legacy infrastructure; (iii) development of a framework for assessing future funding needs. Read moreRead less
Elucidation of genetic and physiological factors controlling biosynthesis of sesquiterpenoids in sandalwood, Santalum spp. Plantation sandalwood removes pressure from natural populations and is a profitable long term investment. Australia is in a highly competitive position with regards to market supply but this cannot be taken for granted. This research seeks to understand the complex biology of sandalwood using the latest genomic and molecular technologies. This knowledge will be applied thro ....Elucidation of genetic and physiological factors controlling biosynthesis of sesquiterpenoids in sandalwood, Santalum spp. Plantation sandalwood removes pressure from natural populations and is a profitable long term investment. Australia is in a highly competitive position with regards to market supply but this cannot be taken for granted. This research seeks to understand the complex biology of sandalwood using the latest genomic and molecular technologies. This knowledge will be applied through directed, marker-assisted tree selection and improved plantation management. Ultimately we are developing a highly advanced production system with which Australia can lead Sandalwood production. Sandalwood plantations use a variety of native perennial hosts, increase biodiversity, help manage underground water resources and address carbon sequestration demands.Read moreRead less