Distribution Kinetics Of Opioids Used In Substitution Programs
Funder
National Health and Medical Research Council
Funding Amount
$196,527.00
Summary
Heroin addiction is a major national and international problem costing hundreds of millons of dollars to Australia alone. The major form of treatment is methadone taken as maintenance treatment once a day. While methadone is effective in most addicts, about one third of them complain that it does not last long enough and they either tolerate this inadequate form of treatment or are prescribed a newer drug as part of a clinical trial or drop out and revert to heroin. We have previously shown that ....Heroin addiction is a major national and international problem costing hundreds of millons of dollars to Australia alone. The major form of treatment is methadone taken as maintenance treatment once a day. While methadone is effective in most addicts, about one third of them complain that it does not last long enough and they either tolerate this inadequate form of treatment or are prescribed a newer drug as part of a clinical trial or drop out and revert to heroin. We have previously shown that the blood levels of methadone are important in determining its best use and specifically, that those addicts for whom methadone does not hold have a greater drop in their blood levels after methadone has been absorbed into the body. This drop in blood levels is mainly due to methadone's redistribution throughout the body. Very little is known about how methadone distributes and redistributes throughout the body but it appears that the lung is the most important organ. A number of questions need to be answered to improve methadone's use: 1. How quickly is methadone taken up into the lung compared to the brain; 2. Why is the lung able to take up and release a large amount of methadone; 3. How does decreased respiration influence the lung and brain uptake of methadone; 4. What happens when another drug is prescribed (such as an antidepressant) which reduces the lung uptake of methadone; 5. Do some of the newer drugs for heroin addiction have better lung distribution and binding properties. We will perform studies of the concentrations of methadone and newer drugs in sheep that will provide the scientific basis for answering these questions and permit better use of drug treatment for heroin addiction.Read moreRead less
Maximising The Effectiveness Of Interactive Automated Programs For Smoking Cessation
Funder
National Health and Medical Research Council
Funding Amount
$922,582.00
Summary
This project is to design, implement and trial automated programs to help smokers quit. It makes use of the powers of modern computing and telecommunications. It uses information the person provides to personally tailor advice and assistance to smokers as they progress from beginning to think about quitting through to being a stable, happy non-smoker. In particular, we are interested in the relative value of detailed advice as compared with the capacity of modern messaging technology (SMS, voice ....This project is to design, implement and trial automated programs to help smokers quit. It makes use of the powers of modern computing and telecommunications. It uses information the person provides to personally tailor advice and assistance to smokers as they progress from beginning to think about quitting through to being a stable, happy non-smoker. In particular, we are interested in the relative value of detailed advice as compared with the capacity of modern messaging technology (SMS, voice, images) to provide a set of prompts and reminders that help smokers manage a quit attempt and help prevent them relapsing back to smoking. Once we have developed the interventions, we will subject them to a rigorous scientific trial to see how effective they are and also how cost-effective they prove. Our hope is that these programs will provide a cheap, accessible and effective way of helping smokers to quit and thus help reduce the huge toll of smoking-related disease.Read moreRead less
Can Self-management Education Programs Improve Outcomes Of People With Osteoarthritis?
Funder
National Health and Medical Research Council
Funding Amount
$343,874.00
Summary
Arthritis is a very common disease associated with pain, disability and poor quality of life. An important way that people with arthritis can deal with the disease is through using a variety of self-management behaviours and coping strategies as well as becoming well informed about the best available treatments. A specific course was developed in he US to help people self-manage. It has been available in Australia for 20 years through Arthritis Foundations and has become their core business. Tre ....Arthritis is a very common disease associated with pain, disability and poor quality of life. An important way that people with arthritis can deal with the disease is through using a variety of self-management behaviours and coping strategies as well as becoming well informed about the best available treatments. A specific course was developed in he US to help people self-manage. It has been available in Australia for 20 years through Arthritis Foundations and has become their core business. Treatment guidelines used by doctors to treat people with arthritis regularly recommend that patients should be referred to such courses. Although the course is widely distributed, the evidence scientific evidence regarding its effectiveness is patchy, and some overviews suggest it is not useful at all. Confusion exists regarding the value of the course. While treatment guidelines advise doctors to refer patients to the program by very few GPs, Rheumatologist or Orthopaedic surgeons do refer. The proposed study is a large controlled trial which will provide essential evidence to inform patients, doctors and policy makers on the benefits of the course. It will involve people with well defined moderate to severe arthritis who have consulted a surgeon or rheumatologist. People will be randomised to receive the intervention (two hours per week, six session course including an 'arthritis self-help' book) will be compared with people in a control group (who only receive the book without instruction). People will be followed for 1 year to see if the course improves quality of life, health behaviours, and whether less health care resources (ie attendance at doctors or less medication use) are used. The results of this study will be influential in determining government policy as the number of people with chronic diseases like arthritis is rapidly growing and the acute healthcare system, including hospitals, are poorly equipped to deal with this growing problem.Read moreRead less