One coordinate carbon and boron: Universal progenitor ligands. Compounds with bonds between metals and carbon (organometallic chemistry) underpin innumerable important industrial processes from fine chemicals to bulk agrochemical and polymer synthesis. Yet the simplest example, a single atom of carbon bound to a metal has only recently been discovered and is poorly understood. Australia's fledgling boron fine chemicals industry similarly benefits from metal-based processes. However, compounds wi ....One coordinate carbon and boron: Universal progenitor ligands. Compounds with bonds between metals and carbon (organometallic chemistry) underpin innumerable important industrial processes from fine chemicals to bulk agrochemical and polymer synthesis. Yet the simplest example, a single atom of carbon bound to a metal has only recently been discovered and is poorly understood. Australia's fledgling boron fine chemicals industry similarly benefits from metal-based processes. However, compounds with a single boron atom bound to a metal remain unknown. This proposal addresses metal-carbon and metal-boron chemistry from the most basic perspective, that of a single atom of boron or carbon, including the development of novel synthetic approaches and skills for the characterisation of such curious species.Read moreRead less
Bimolecular chemistry at very low temperatures. Many chemical reactions involve short-lived and highly reactive intermediates that cannot be observed under ordinary reaction conditions. Hence, much of this chemistry is shrouded in mystery. This project aims to develop the ability to observe and monitor such reactions directly using a combination of spectroscopies at very low temperatures, where the molecules are more stable and reactions slower. These studies will give quantitative information ....Bimolecular chemistry at very low temperatures. Many chemical reactions involve short-lived and highly reactive intermediates that cannot be observed under ordinary reaction conditions. Hence, much of this chemistry is shrouded in mystery. This project aims to develop the ability to observe and monitor such reactions directly using a combination of spectroscopies at very low temperatures, where the molecules are more stable and reactions slower. These studies will give quantitative information on the nature of the reactive intermediates themselves, the nature of the products formed, and the reaction dynamics, and they are of fundamental importance for an understanding of chemical reactivity generally. The methodology developed will be applicable to the investigation of a wide range of processes.Read moreRead less
New mechanisms and methods in carbene and nitrene chemistry. Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will ....New mechanisms and methods in carbene and nitrene chemistry. Carbenes and nitrenes are highly reactive intermediates of theoretical and mechanistic significance and synthetic versatility in organic chemistry. In spite of high reactivity, selective and high-yielding reactions can be performed, leading to products that may be difficult or impossible to synthesise by other methods. They have practical applications in photo-affinity labelling of biomolecules, and photolithography. This project will contribute fundamental knowledge of the nature and reactions of these species by using direct spectroscopic observation. We are proposing the occurrence of novel types of reactions and the formation of several new reactive intermediates as well as a technique for the stabilization of reactive intermediates by incorporation into macrocyclic frameworks.Read moreRead less
The Baylis-Hillman Reaction: Asymmetric Organocatalysis and Applications. Many drugs come in two chiral mirror images (enantiomers) where the therapeutic effect is usually associated with only one while the other has no effect or can be harmful as was the case with thalidomide. Chemical reactions that yield just the desired mirror image, or enantiomer, and not the other are therefore in great demand and heavily pursued by the pharmaceutical, fine chemical and materials industries as a frontier ....The Baylis-Hillman Reaction: Asymmetric Organocatalysis and Applications. Many drugs come in two chiral mirror images (enantiomers) where the therapeutic effect is usually associated with only one while the other has no effect or can be harmful as was the case with thalidomide. Chemical reactions that yield just the desired mirror image, or enantiomer, and not the other are therefore in great demand and heavily pursued by the pharmaceutical, fine chemical and materials industries as a frontier technology. This project will result in the development of novel catalytic reactions that allow the synthesis of chiral chemicals in a cost-efficient and green manner needed by many industries, and also training of students with highly desirable synthetic skills to lead the next wave in pharmaceuticals and biotechnology.Read moreRead less
Reactive intermediates and microwave-assisted organic reactions. The use of our chemistry to help develop new, safer, better drugs against schizophrenia is a strong driving force for this research. This relates to the National Research Priority of promoting and maintaining good health, ageing well and productively, and preventative healthcare. Microwave-assisted chemical synthesis will undoubtedly become a very important methodology in the pharmaceutical industry, and our work will help develop ....Reactive intermediates and microwave-assisted organic reactions. The use of our chemistry to help develop new, safer, better drugs against schizophrenia is a strong driving force for this research. This relates to the National Research Priority of promoting and maintaining good health, ageing well and productively, and preventative healthcare. Microwave-assisted chemical synthesis will undoubtedly become a very important methodology in the pharmaceutical industry, and our work will help developing such know-how in Australia and thereby contribute to the Australian economic fabric. Read moreRead less
Integration of Electrochemistry and Green Chemistry: A Roadmap for Scientific Innovation. Electrochemistry represents an enabling science in physical, chemical and life sciences. It plays a key role in fundamental studies and in Australia's industrial capacity to exploit emerging technologies. Research conducted synergistically within the ARC Centre for Green Chemistry would enable the Monash Electrochemistry Group to develop and exploit new concepts. In the national interest, the Fellowship ....Integration of Electrochemistry and Green Chemistry: A Roadmap for Scientific Innovation. Electrochemistry represents an enabling science in physical, chemical and life sciences. It plays a key role in fundamental studies and in Australia's industrial capacity to exploit emerging technologies. Research conducted synergistically within the ARC Centre for Green Chemistry would enable the Monash Electrochemistry Group to develop and exploit new concepts. In the national interest, the Fellowship would: facilitate global participation in cutting-edge science derived from electrochemical and green chemical concepts; provide commercial opportunities for new and mature chemical industries; expand postgraduate training; and promote technology exchange with Australian and international leading-edge research organisations.Read moreRead less
Large amplitude Fourier transformed voltammetry: paths towards more efficient data evaluation strategies, enhanced insights and innovation in dynamic electrochemistry. Electrochemistry represents an enabling discipline in many branches of science. The aim of this research is to integrate the collective skills of an international consortium of experts in electrochemistry, electrical engineering, computing and mathematics in order to implement a blueprint proposed for innovation in electrochemic ....Large amplitude Fourier transformed voltammetry: paths towards more efficient data evaluation strategies, enhanced insights and innovation in dynamic electrochemistry. Electrochemistry represents an enabling discipline in many branches of science. The aim of this research is to integrate the collective skills of an international consortium of experts in electrochemistry, electrical engineering, computing and mathematics in order to implement a blueprint proposed for innovation in electrochemical science. In the national interest, the project will facilitate global participation in cutting-edge science derived from electrochemical concepts, provide commercial opportunities in the area of scientific instrumentation and promote technology exchange with Australian and international leading-edge research organizations.Read moreRead less
A blueprint for an intelligent instrumental, theoretical and experimental unification of a myriad of voltammetric and related electrochemical techniques. Electrochemistry is a prominent discipline in many areas of fundamental and applied science (for example, electron transfer reactions, corrosion, sensors, photovoltaics). The aim of the research proposal is to utilise skills available at Monash University and those of a national and international consortium of experts in electrochemistry, elec ....A blueprint for an intelligent instrumental, theoretical and experimental unification of a myriad of voltammetric and related electrochemical techniques. Electrochemistry is a prominent discipline in many areas of fundamental and applied science (for example, electron transfer reactions, corrosion, sensors, photovoltaics). The aim of the research proposal is to utilise skills available at Monash University and those of a national and international consortium of experts in electrochemistry, electrical engineering, computing and mathematics to introduce a new integrated instrumental, theoretical and experimental concept that will provide a blueprint for innovation in electrochemical science. An expected outcome is that important advances relevant to Australian Industry will be achieved in the area of scientific instrumentation and in modern applications of electrochemistry.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0775725
Funder
Australian Research Council
Funding Amount
$465,000.00
Summary
Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measureme ....Molecular separation and characterisation - A facility for advanced mass spectroscopy and chromatography. Characterising molecular composition is a basic need for the progress of many sciences. It is used to examine traditional and modern medicinal chemistry, bio-active peptides, molecular modulation of chemical properties, markers of disease and system status, and can also be used to elucidate molecular mechanisms and interactions in a system. This can only be achieved through precise measurement using the frontier technologies described in this grant. This proposal ensures international competitiveness on a broad front, and supports highest level research training and bio/chemical/medical research in several priority research areas. Read moreRead less
Bio-inspired Catalysts for Water Oxidation. Successful completion of the project will result in the development of devices that utilise redox active manganese clusters to catalyse the oxidation of water. This achievement would place us at the forefront of international efforts to develop devices that can split water into hydrogen and oxygen, an endeavour which has the potential to solve pressing energy demands. As an added benefit, these devices can be adapted for the purposes of carrying out th ....Bio-inspired Catalysts for Water Oxidation. Successful completion of the project will result in the development of devices that utilise redox active manganese clusters to catalyse the oxidation of water. This achievement would place us at the forefront of international efforts to develop devices that can split water into hydrogen and oxygen, an endeavour which has the potential to solve pressing energy demands. As an added benefit, these devices can be adapted for the purposes of carrying out the catalytic oxidation of organic substrates, for which a variety of industrial and environmental applications can be envisaged.
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