Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental condition ....Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental conditions (especially exposure to steroid-like pollutants) is crucial to support breeding programs of endangered species and may improve veterinary and medicinal treatment of premature animals and humans. This multi-disciplinary, international collaboration provides an international training ground and two-way exchange of students and postdocs.Read moreRead less
Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
Breaking bandwidth barriers: Non-volatile tuneable terahertz metamaterials. This project aims to investigate non-volatile tuneable terahertz (THz) metamaterials, based on the exploitation of phase change materials. Tuneable metamaterial-based THz devices, such as filters and modulators, could generate significant downstream intellectual property for wireless applications. This fills a critical need to meet the increasing demand for greater bandwidth between desktop devices. Expected outcomes inc ....Breaking bandwidth barriers: Non-volatile tuneable terahertz metamaterials. This project aims to investigate non-volatile tuneable terahertz (THz) metamaterials, based on the exploitation of phase change materials. Tuneable metamaterial-based THz devices, such as filters and modulators, could generate significant downstream intellectual property for wireless applications. This fills a critical need to meet the increasing demand for greater bandwidth between desktop devices. Expected outcomes include understanding the interaction between THz signals and phase change materials, tuneable metamaterials, and devices that can steer and modulate THz signals with unprecedented agility and compactness, enabling future high-bandwidth Bluetooth-like data transfer.Read moreRead less
A new paradigm for surfactant composition and function - how do lungs cope with stress? Our research will increase the understanding of the scope of change and precise molecular interactions occurring in the surfactant lipids and proteins of animals under physiological stress. The novel insights will improve the treatment of lung diseases (such as chronic obstructive pulmonary disease and acute lung injury). We have formed a team of international surfactant researchers all experts in state-of-th ....A new paradigm for surfactant composition and function - how do lungs cope with stress? Our research will increase the understanding of the scope of change and precise molecular interactions occurring in the surfactant lipids and proteins of animals under physiological stress. The novel insights will improve the treatment of lung diseases (such as chronic obstructive pulmonary disease and acute lung injury). We have formed a team of international surfactant researchers all experts in state-of-the-art chemical and biophysical technologies relating to surfactant. These collaborations will bring new technological applications to Australia and provide outstanding cross-disciplinary training for postgraduate students and research staff at the interface between animal physiology, biophysical chemistry and respiratory medicine.Read moreRead less
Epigenetic Regulation of Fetal and Placental Development. Perturbations of the environment of the early embryo can alter fetal and placental growth. The mechanisms by which the early environment alters development of the fetal adrenal-placental axis are unknown. This axis coordinates fetal growth and development to ensure a successful transition from intra- to extrauterine life. We propose a novel role for the epigenetic regulation of imprinted genes in the activation of the fetal adrenal and in ....Epigenetic Regulation of Fetal and Placental Development. Perturbations of the environment of the early embryo can alter fetal and placental growth. The mechanisms by which the early environment alters development of the fetal adrenal-placental axis are unknown. This axis coordinates fetal growth and development to ensure a successful transition from intra- to extrauterine life. We propose a novel role for the epigenetic regulation of imprinted genes in the activation of the fetal adrenal and in placental growth and differentiation. This proposal extends the 'genetic conflict' hypothesis of the role of imprinted genes beyond its current focus on the regulation of fetal nutrient supply and demand.Read moreRead less
Defining how serotonin regulates gut motility. This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important ....Defining how serotonin regulates gut motility. This project aims to deepen knowledge of gastrointestinal physiology, and reveal the mechanisms by which the major gastrointestinal signalling molecule, serotonin, regulates gut peristalsis. Almost all of the serotonin in our body is made in the gastrointestinal tract where it controls many functions, including how our gut wall contracts during peristalsis. Proper control of gut peristalsis and the transit of material through our bowel is important for our health. This project expects to define how serotonin controls peristalsis, where in the bowel this serotonin comes from, how serotonin communicates with the nervous system in our gastrointestinal tract, and how the cells that synthesise gut serotonin respond to contraction to trigger the secretion of serotonin.Read moreRead less
Examining the links between obesity and insulin resistance. Obesity prevalence is rapidly increasing in Australia and contributes to the onset of many chronic diseases, such as diabetes, heart disease and cancer. This project will examine how obesity contributes to disease risk and how modifying nutrient delivery and other interventions that protect from cellular stress reduces these risks.
Discovery Early Career Researcher Award - Grant ID: DE210101904
Funder
Australian Research Council
Funding Amount
$385,322.00
Summary
Next-Generation LIDAR with Novel Microresonator Frequency Combs. This project aims to develop the science that would enable a new low-cost laser radar (LIDAR) for imaging the world around us. LIDAR has applications in facial recognition, forestry and autonomous vehicles – our new device will uniquely offer the ability to work underwater thereby opening up new possibilities for maritime environmental and vehicle monitoring. Our approach exploits a new form of optical pulse propagation in precise ....Next-Generation LIDAR with Novel Microresonator Frequency Combs. This project aims to develop the science that would enable a new low-cost laser radar (LIDAR) for imaging the world around us. LIDAR has applications in facial recognition, forestry and autonomous vehicles – our new device will uniquely offer the ability to work underwater thereby opening up new possibilities for maritime environmental and vehicle monitoring. Our approach exploits a new form of optical pulse propagation in precisely shaped crystals to generate bespoke laser pulses that enable high-speed and precise ranging to targets of interest. The science behind these new types of optical pulses offers the ability for Australia to lead a new scientifically and industrially important field.Read moreRead less
Dynamic phased array antennas for terahertz detection and ranging. The project aims to create reciprocal electrically-tuneable phased array antennas for terahertz waves. The antennas will comprise varactor diodes, analogue phase shifters, and dielectric resonator arrays to rapidly transmit and receive beams with high directivity and performance. The intended outcome is an integrated platform for short-range terahertz detection and ranging. This platform could be used in personal radar and drone- ....Dynamic phased array antennas for terahertz detection and ranging. The project aims to create reciprocal electrically-tuneable phased array antennas for terahertz waves. The antennas will comprise varactor diodes, analogue phase shifters, and dielectric resonator arrays to rapidly transmit and receive beams with high directivity and performance. The intended outcome is an integrated platform for short-range terahertz detection and ranging. This platform could be used in personal radar and drone-based radar, and high-contrast standoff detection. The project could benefit public security and welfare.Read moreRead less
Next Generation Terahertz Materials. We will investigate novel tuneable terahertz (THz) metamaterials, based on the exploitation of phase change materials. Tunable metamaterial-based terahertz devices, such as modulators and filters, will potentially generate significant downstream IP for short-path wireless applications. This fills a critical need to meet the increasing demand for greater bandwidth. Elucidation of the fundamental science underlying the interaction between terahertz signals and ....Next Generation Terahertz Materials. We will investigate novel tuneable terahertz (THz) metamaterials, based on the exploitation of phase change materials. Tunable metamaterial-based terahertz devices, such as modulators and filters, will potentially generate significant downstream IP for short-path wireless applications. This fills a critical need to meet the increasing demand for greater bandwidth. Elucidation of the fundamental science underlying the interaction between terahertz signals and phase-change materials will enable tuneable metamaterials. A major leap will be devices that can steer and modulate terahertz signals with unprecedented agility and compactness; enabling future high-bandwidth desktop data transfer.Read moreRead less