Computed microscopy: solving the inverse problem of optical microscopy to image deeper into biological tissue. This project aims to enable 3D optical microscopy to image deeper within tissue, ultimately aiding research fields such as neurobiology. This will be achieved by a foundational approach called computed cicroscopy that combines novel numerical methods, high performance computing and optical microscopy. This project aims to develop a 3D quantitative imaging method that will provide unprec ....Computed microscopy: solving the inverse problem of optical microscopy to image deeper into biological tissue. This project aims to enable 3D optical microscopy to image deeper within tissue, ultimately aiding research fields such as neurobiology. This will be achieved by a foundational approach called computed cicroscopy that combines novel numerical methods, high performance computing and optical microscopy. This project aims to develop a 3D quantitative imaging method that will provide unprecedented insight into the structure of tissue with sub-cellular detail. This information can then be used to computationally reverse light scattering within the sample, allowing fluorescence microscopy at unprecedented depths within tissue.Read moreRead less
Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental condition ....Environmental Control of Developmental Plasticity of Vertebrate Cardio-Pulmonary Systems. Our research will generate the first comprehensive picture of how environmental conditions are transduced to control the development of the vertebrate respiratory and cardiovascular systems over the perinatal period. The research will demonstrate how physiological systems are modified and hence evolve. Moreover, understanding the developmental pathology in embryos induced by changing environmental conditions (especially exposure to steroid-like pollutants) is crucial to support breeding programs of endangered species and may improve veterinary and medicinal treatment of premature animals and humans. This multi-disciplinary, international collaboration provides an international training ground and two-way exchange of students and postdocs.Read moreRead less
Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine m ....Coping With Pressure: Respiratory Biology of Marine Mammals. Many marine mammals undergo severe, protracted lung collapse during deep dives. They also exhibit prolonged periods of apnea during sleep. In humans, lung collapse and sleep apnea both represent severe respiratory dysfunction. Pulmonary surfactant, a complex mixture that lines the lung, stabilises the lungs in terrestrial mammals, preventing lung collapse. Here, we propose a comprehensive examination of respiratory function in marine mammals. This study will significantly advance our knowledge of the diving physiology of Australian marine mammals. A detailed examination of the respiratory and surfactant systems of marine mammals may also reveal adaptations that enable these animals to endure sleep apnea and lung collapse.Read moreRead less
Modulating the molecular and cellular physiology of ageing skeletal muscle. Understanding the underlying mechanisms of how ageing affects muscle is of increasing importance to the community as the number of older persons in the population continues to escalate and the age of retirement increases. Old muscles are slower and weaker than young muscles, and are more easily injured. This proposal is focussed on developing safe therapies to prevent or reverse these age-related effects. Making old musc ....Modulating the molecular and cellular physiology of ageing skeletal muscle. Understanding the underlying mechanisms of how ageing affects muscle is of increasing importance to the community as the number of older persons in the population continues to escalate and the age of retirement increases. Old muscles are slower and weaker than young muscles, and are more easily injured. This proposal is focussed on developing safe therapies to prevent or reverse these age-related effects. Making old muscles young again, is a research strategy that will promote healthy ageing and enable older Australians to enjoy a better quality of life.Read moreRead less
Relaxin: molecular mechanisms of action in the reversal of fibrosis. Defects in relaxin and relaxin receptors are increasingly implicated as a cause of fibrosis which is associated with many disease processes. This study will examine the molecular mechanisms linking relaxin and fibrosis and will determine whether relaxin can be used to reverse the condition.
Australian Laureate Fellowships - Grant ID: FL100100099
Funder
Australian Research Council
Funding Amount
$2,340,409.00
Summary
An accelerating journey to the new era of Petabyte optical memory systems. Optical data storage is one of the core aspects of optical information technology which has been globally recognised as one of the next generation high-technology areas that can boost our economy for sustainable development. However, the emergence of blue ray or high-definition DVDs has identified that current optical data storage technology will soon approach the limit of the data storage capacity of approximately 100 Gi ....An accelerating journey to the new era of Petabyte optical memory systems. Optical data storage is one of the core aspects of optical information technology which has been globally recognised as one of the next generation high-technology areas that can boost our economy for sustainable development. However, the emergence of blue ray or high-definition DVDs has identified that current optical data storage technology will soon approach the limit of the data storage capacity of approximately 100 Gigabytes. The ground-breaking Petabyte data storage technology we will research will result in the storage capacity of 10,000 DVDs in one disc and thus underpin every sector of our modern life such as remote education, portable banking, global e-security and telemedicine as well as lead to enormous economic benefits in Australia.Read moreRead less
Breaking bandwidth barriers: Non-volatile tuneable terahertz metamaterials. This project aims to investigate non-volatile tuneable terahertz (THz) metamaterials, based on the exploitation of phase change materials. Tuneable metamaterial-based THz devices, such as filters and modulators, could generate significant downstream intellectual property for wireless applications. This fills a critical need to meet the increasing demand for greater bandwidth between desktop devices. Expected outcomes inc ....Breaking bandwidth barriers: Non-volatile tuneable terahertz metamaterials. This project aims to investigate non-volatile tuneable terahertz (THz) metamaterials, based on the exploitation of phase change materials. Tuneable metamaterial-based THz devices, such as filters and modulators, could generate significant downstream intellectual property for wireless applications. This fills a critical need to meet the increasing demand for greater bandwidth between desktop devices. Expected outcomes include understanding the interaction between THz signals and phase change materials, tuneable metamaterials, and devices that can steer and modulate THz signals with unprecedented agility and compactness, enabling future high-bandwidth Bluetooth-like data transfer.Read moreRead less
Nonlinear optical effects with low-power non-laser light. This project aims to allow the use of low-cost, low-intensity light sources, such as light-emitting diodes and discharge lamps, to generate nonlinear optical signals in photonic devices. Nonlinear optical effects are vital for telecommunication and signal processing technologies and are presently possible only when the light is produced by a high-power laser. The expected outcome of this project is a theoretical and experimental framework ....Nonlinear optical effects with low-power non-laser light. This project aims to allow the use of low-cost, low-intensity light sources, such as light-emitting diodes and discharge lamps, to generate nonlinear optical signals in photonic devices. Nonlinear optical effects are vital for telecommunication and signal processing technologies and are presently possible only when the light is produced by a high-power laser. The expected outcome of this project is a theoretical and experimental framework that would underpin the development of a new nonlinear photonic technology that does not require lasers, representing a paradigm shift in how photonic devices are designed. This should benefit sensing, telecommunications and defence by cheaper and more efficient transmission of information via media such as the National Broadband Network.Read moreRead less
Brain temperature regulation in mammals: mechanisms and consequences. Mammals detect increases in body temperature predominantly in the brain. Counterintuitively many mammals selectively cool the brain during heat stress, which appears to defeat the mechanism for inducing cooling responses. We intend to investigate this apparent anomaly which we believe is concerned with optimizing water use in hot conditions. We will further investigate the source of water for evaporative cooling by panting and ....Brain temperature regulation in mammals: mechanisms and consequences. Mammals detect increases in body temperature predominantly in the brain. Counterintuitively many mammals selectively cool the brain during heat stress, which appears to defeat the mechanism for inducing cooling responses. We intend to investigate this apparent anomaly which we believe is concerned with optimizing water use in hot conditions. We will further investigate the source of water for evaporative cooling by panting and discover if there has been convergent evolution in thermoregulatory strategies in the eutherian and marsupial lineages. The data we collect will be used to support a new model for thermoregulation in mammals.
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