Derivation Of Pancreatic Beta Cells From Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$2,968,050.00
Summary
People with type 1 diabetes require regular insulin injections because the organ that normally makes insulin, the pancreas, no longer functions. The goal of this program is to derive human fetal pancreas tissues from embryonic stem cells. Such tissue could be used to replace the missing insulin producing cells in people with type 1 diabetes. The program brings together expertise in ES cell biology at Monash University and the leading diabetes research at the Walter and Eliza Hall Institute.
Generation Of Renal Cells From Human Embryonic Stem Cells
Funder
National Health and Medical Research Council
Funding Amount
$281,805.00
Summary
This proposal will gather evidence to show that human embryonic stem cells are capable of forming specific cell types of the embryonic human kidney. Once this is established, methods for the maintenance and directed differentiation of these cells to cell types of the mature kidney will be identified and improved. The results obtained will provide a base for future exploration of the possibility that human embryonic stem cell derived cells can be used to treat damaged kidneys.
NHMRC Research Fellowship. Genetic Modification And Differentiation Of Human Pluripotent Stem Cells: Creating Tools For Regenerative Medicine And Models For Disease
Funder
National Health and Medical Research Council
Funding Amount
$757,297.00
Summary
Human embryonic stem cells (hESCs) can form all the cell types in the body. Cells made from hESCs could be used to test new drugs prior to trials in patients and eventually to replace tissues damaged through accident or disease. My laboratory is turning hESCs into blood, heart and insulin producing cells. We can genetically modify such that the cells fluoresce whenever they develop into these cell types. These 'glowing' hESC lines help us to make different cell types more efficiently.