Endocytosis And Asymmetric Cell Division In Leukemia.
Funder
National Health and Medical Research Council
Funding Amount
$548,258.00
Summary
Self-renewal allows normal haematopoeitic stem cells to constantly replenish the blood system. Conversely, leukemia stem cells use self-renewal to propagate the disease, and utilise the quiescence phase to evade treatment eradication. We identified that the endocytic gene, Ap2a2 enhances haematopoeitic stem cell self-renewal. Through Ap2a2, we are now investigating the role of endocytosis and self-renewal in leukemia and ex vivo expansion of human haematopoietic stem cells.
Investigation Of Haematopoietic And Leukemia Stem Cell Self-renewal.
Funder
National Health and Medical Research Council
Funding Amount
$415,218.00
Summary
The blood stem cell properties of self-renewal and multipotency allows for the constant replenishment of all blood components. Blood cancer stem cells use self-renewal to propagate disease, and can enter a quiescent-dormant phase to evade treatment. My research focuses on the identification and mechanisms of new genes that govern these unique blood stem cell properties, and to investigate whether these genes are also important in blood cancers.