Molecular Probes for Bio-Metals. The nutrient trace metals are essential to life. Problems with the metabolism of iron, copper and zinc are associated with neuro-degenerative diseases such as Alzheimer's, Parkinson's and CJD (Creutzfeldt-Jakob disease). This proposal will develop molecular probes for detection of iron, zinc, copper, manganese and nickel within biological cells. The work will allow examination of the molecular roles of these bio-metals in unprecedented detail and lead to a bette ....Molecular Probes for Bio-Metals. The nutrient trace metals are essential to life. Problems with the metabolism of iron, copper and zinc are associated with neuro-degenerative diseases such as Alzheimer's, Parkinson's and CJD (Creutzfeldt-Jakob disease). This proposal will develop molecular probes for detection of iron, zinc, copper, manganese and nickel within biological cells. The work will allow examination of the molecular roles of these bio-metals in unprecedented detail and lead to a better understanding of their roles in normal metabolism and in disease.Read moreRead less
Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. Th ....Investigation and Prediction of the Novel Properties of Dendrimers. Dendrimers are a new class of highly branched polymers, which have, until now, been difficult to characterise by conventional means. This project will develop and apply molecular simulation techniques to reveal the chemical and physical properties of dendrimers and their interactions with other molecules. These novel molecules potentially have beneficial applications to areas such as drug delivery and electronic materials. The outcome of this work will assist in the exploitation of this beneficial application and will provide the basis for efficient processing.Read moreRead less
Redox processes in Bayer liquors. Alumina, and the aluminium produced from it, are amongst Australia's most important mineral commodities, earning about $8 billion p.a. in exports. However, ongoing technological improvements are needed for Australian producers to remain globally competitive. This project addresses a key problem in alumina production - the behaviour of organic impurities - which will help to increase industrial productivity and reduce energy consumption. Insights gained from this ....Redox processes in Bayer liquors. Alumina, and the aluminium produced from it, are amongst Australia's most important mineral commodities, earning about $8 billion p.a. in exports. However, ongoing technological improvements are needed for Australian producers to remain globally competitive. This project addresses a key problem in alumina production - the behaviour of organic impurities - which will help to increase industrial productivity and reduce energy consumption. Insights gained from this research will also minimize the environmental and occupational health impacts of various process emissions, making the industry more sustainable.Read moreRead less
Operating Mechanisms and Dynamics of Molecular Motors. This project will enhance the nation's expertise in nanotechnology which is emerging as an important enabling technology for the creation of sophisticated novel materials. It is in the national interest to be at the forefront of this field because of its great potential for economic advantage such as the creation of new valued-added export industries based on "bottom-up" fabrication.
Heat capacities of Bayer liquors to 300C. Alumina refining is one of Australia's most important industries, earning ~$6 billion per year export income. However, major productivity gains are required for Australian producers to remain globally competitive. More accurate thermodynamic calculations, covering the full plant operating range, are seen by the industry as an important way to increase productivity, minimise energy consumption and cut greenhouse emissions. To achieve these aims, we must e ....Heat capacities of Bayer liquors to 300C. Alumina refining is one of Australia's most important industries, earning ~$6 billion per year export income. However, major productivity gains are required for Australian producers to remain globally competitive. More accurate thermodynamic calculations, covering the full plant operating range, are seen by the industry as an important way to increase productivity, minimise energy consumption and cut greenhouse emissions. To achieve these aims, we must extend current theoretical understanding and establish an experimental capability, hitherto unavailable in Australia, for measuring heat capacities and densities of solutions to temperatures as high as 300 C.Read moreRead less
The Role of Thermodynamics and Kinetics in Self-Assembly of Metallic Nanocrystals. Global interest in metallic nano-crystals has recently increased dramatically as the realized applications of these structures begin to span the fields of nanotechnology and nano-biotechnology. In all these applications, control of the size and morphology of the nano-particles is critically important, as these characteristics determine their electronic, optical and catalytic properties. This requires an understa ....The Role of Thermodynamics and Kinetics in Self-Assembly of Metallic Nanocrystals. Global interest in metallic nano-crystals has recently increased dramatically as the realized applications of these structures begin to span the fields of nanotechnology and nano-biotechnology. In all these applications, control of the size and morphology of the nano-particles is critically important, as these characteristics determine their electronic, optical and catalytic properties. This requires an understanding of the underlying thermodynamic and kinetic driving forces, which govern nano-particle nucleation, growth and stability. This project will investigate the role of surface thermodynamics and growth kinetics in the nucleation, growth and stability of metallic nano-crystals in order to understand how to control their synthesis.Read moreRead less