Erythroid Molecular Cascades Involving The Tyrosine Kinase Lyn
Funder
National Health and Medical Research Council
Funding Amount
$496,500.00
Summary
Mature red and white cells develope from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (Epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for Epo to stimulate them to become mature functio ....Mature red and white cells develope from hemopoietic stem cells in the adult bone marrow. The production of red blood cells is primarily controlled by the hormone erythropoietin (Epo). The availability of this hormone in a recombinant form has aided in the treatment of numerous forms of anaemia resulting from kidney failure, malignancies, and AIDS. Previously we had identified that the protein Lyn must be present inside primitive red blood cells for Epo to stimulate them to become mature functional cells. Recently, we have demonstrated that mice lacking the Lyn gene develope major problems with their red blood cells. We have identified several molecules which interact with Lyn in red blood cells. We have shown that a molecule called Cbp is important for Epo function in individual red blood cells and now we plan to investigate its function in whole animals. We have shown that a new molecule called Arp is important for red blood cell development. This protein moves in and out of the nucleus (where DNA is stored) and may be important in the regulation of genes needed for red blood cells. The third gene (AFAPbeta) is also novel and is closely related to another called AFAP-110, which can exert effects on the structure of a cell. Since red blood cells have to shrink considerably during their development, the role of AFAPbeta on red blood cell structure will also be investigated. From these experiments we should develop a much better understanding of how the production of red blood cells is controlled and how diseases of red blood cells (such as anaemia) occur.Read moreRead less
Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the p ....Toward a Female Stoic Tradition: Women's Writings in England, 1600-1800. This project aims to investigate the neglected history of women’s engagement with Stoic ideas in early modern England. It expects to generate new knowledge of a distinctive strand of women’s Stoic thought by taking a novel interdisciplinary approach to different genres of early modern writing. The intended outcomes include a new understanding of women’s valuable contributions to philosophy, literature, and politics in the period, as well as a greater appreciation of the gender-inclusivity of Stoic philosophy. This should provide significant benefits, such as the development of Stoic therapeutic techniques informed by women’s experiences, and the promotion of gender equality through the recognition of women’s intellectual history.Read moreRead less
Understanding selfie-editing apps in youth visual digital cultures. This project aims to investigate how young people navigate identity and body image concerns online through new digital editing tools provided by selfie-editing apps. The project expects to generate new knowledge about the literacies young people use in reading, evaluating and editing images of themselves, and the role of digital technologies in forming young people’s embodied identities, using an innovative participatory methodo ....Understanding selfie-editing apps in youth visual digital cultures. This project aims to investigate how young people navigate identity and body image concerns online through new digital editing tools provided by selfie-editing apps. The project expects to generate new knowledge about the literacies young people use in reading, evaluating and editing images of themselves, and the role of digital technologies in forming young people’s embodied identities, using an innovative participatory methodology. Expected outcomes include a new evidence base and youth-centred conceptual framework on the connections between youth selfie-editing, body image, and wellbeing. This should provide significant benefits in helping young people to better navigate body image and wellbeing in online cultures.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101382
Funder
Australian Research Council
Funding Amount
$410,154.00
Summary
Nature-culture continuities in medieval philosophy and theology. While nature and culture tend to be opposed to one another in modern philosophy, in medieval thought there are many continuities between the two domains. This project will provide the first sustained historical study of nature-culture continuities in medieval Latin philosophy and theology, examining the areas of: cognition; language; semiotics; ethics and politics; animality; ecology; metaphysics; and God. The project will fill a s ....Nature-culture continuities in medieval philosophy and theology. While nature and culture tend to be opposed to one another in modern philosophy, in medieval thought there are many continuities between the two domains. This project will provide the first sustained historical study of nature-culture continuities in medieval Latin philosophy and theology, examining the areas of: cognition; language; semiotics; ethics and politics; animality; ecology; metaphysics; and God. The project will fill a significant gap in medieval intellectual history, enhance Australia’s research capacity in the history of philosophy and history of theology, and demonstrate how medieval ideas can inform contemporary debates about humanity’s relationship to the natural world. Read moreRead less
Virtue with Aristotle: Recovering an Ancient Ethical Theory for Our Time. This project aims to show how Aristotle’s theory of virtue can guide our individual and collective attempts to live good human lives in challenging times. This project expects to produce the first comprehensive study of Aristotle’s concept of virtue in all three areas of human activity in which he applies it (moral action, theoretical cognition, and craft and artistic production) and to show its relevance for contemporary ....Virtue with Aristotle: Recovering an Ancient Ethical Theory for Our Time. This project aims to show how Aristotle’s theory of virtue can guide our individual and collective attempts to live good human lives in challenging times. This project expects to produce the first comprehensive study of Aristotle’s concept of virtue in all three areas of human activity in which he applies it (moral action, theoretical cognition, and craft and artistic production) and to show its relevance for contemporary ethical theory and practice. Expected outcomes of this project include enhanced understanding of the concepts of virtue and flourishing and their historical roots in Aristotle’s ethical writings. This should provide significant benefits, such as building our collective resilience.Read moreRead less
Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent ....Evaluating the feasibility and effect of using a hospital wide coordinated approach to introduce evidence-based changes for pain management. This project will develop a comprehensive educational program and approach to pain management for public and private hospitals that could be used by other hospitals elsewhere. An educational program for hospitals staff, and specifically for Pain Resource Nurses, will be produced. This project has the potential to minimise the experience of pain and prevent widespread complications associated with pain for all hospitalised patients, irrespective of diagnosis or reason for admission. It is also envisaged that this project will establish a model of change that could be used to facilitate evidence-based practice in other aspects of healthcare apart from pain.Read moreRead less
Evolution and the immune system: genetic differences in immune response between human populations due to adaptation to living in different geo-climatic locations. The project, which investigates the genetics of inter-population differences in immune response, will lead to advances in immunology and population genetics research, explain present population specific differences in disease incidence and possibly forecast future population trends of diseases such as asthma and allergy. The study will ....Evolution and the immune system: genetic differences in immune response between human populations due to adaptation to living in different geo-climatic locations. The project, which investigates the genetics of inter-population differences in immune response, will lead to advances in immunology and population genetics research, explain present population specific differences in disease incidence and possibly forecast future population trends of diseases such as asthma and allergy. The study will strengthen ties with collaborators around the world, thus promoting excellence in Australian research and gain Australia prestige in the international community as a country that produces research of global significance. Understanding the immune system's 'recent evolutionary roots' has implications for the health of Australians, especially in light of Australia's increasingly multi-ethnic background.Read moreRead less
Missing workers: retaining mature age women workers to ensure future labour security. This project will generate new data and analyses of the factors affecting the retention of mature age women in paid work. It will produce an evidence base on mature age women's employment for the development of policy frameworks aimed at strengthening labour security in the aged care and other sectors.
The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being dev ....The production of pay (in)equity for women: a study of emerging occupations. The aims of this project are to extend understanding of current impediments to pay equity for women, and to elaborate the ways in which pay inequality is re-created in new contexts. The focus is on emerging occupations likely to provide increasing employment opportunities in the near future. This is highly significant research at a time of structural change and when new procedures for addressing pay equity are being developed in several States following pay equity inquiries. Expected outcomes include enhanced comprehension of the reproduction of pay inequality and evidence to assist the advancement of pay equity through identified mechanisms and strategies.Read moreRead less
Christianity, conflict, and culture: an anthropological investigation of the political role of churches in Solomon Islands. This project contributes to a better understanding of one of Australia's closest neighbours, Solomon Islands. This nation, the site of political turmoil in recent years, is now the focus of an Australian-led Regional Assistance Mission. Many scholars and policy makers have commented on the importance of Christian organizations during the crisis in Solomon Islands and the ne ....Christianity, conflict, and culture: an anthropological investigation of the political role of churches in Solomon Islands. This project contributes to a better understanding of one of Australia's closest neighbours, Solomon Islands. This nation, the site of political turmoil in recent years, is now the focus of an Australian-led Regional Assistance Mission. Many scholars and policy makers have commented on the importance of Christian organizations during the crisis in Solomon Islands and the need to incorporate them in current attempts to restore stability and prosperity. However, most discussions are not informed by an understanding indigenous Christian belief and practice, a lacuna that this project aims to fill by providing an ethnographic investigation of how church-linked groups engage with secular national and international organizations. Read moreRead less