New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these ....New models for the role of chromatin in controlling inducible gene expression. This proposal aims to test novel models of how packaging of DNA in the nucleus plays a fundamental role in gene expression. Understanding these concepts is important in the context of successful gene therapy where major hurdles need to be overcome. This work also has implications for somatic cell therapy since it is important to understand how genes are expressed in order to successfully reprogram cells. Both of these areas are important to the Biotechnology industry. Answering questions about higher order chromatin structure in gene transcription will provide cutting edge, innovative knowledge that will have international significance. Read moreRead less
Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. Inte ....Epigenetic silencing in vertebrates: evolution and function from the bottom-up. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional genomics in Australia, with the research priority of Frontier Technologies for Building and Transforming Australian Industries and priority goals in Breakthrough Science and Frontier Technologies. This project focuses on important biological questions surrounding gene regulation and sex chromosome evolution. International attention has already resulted in genome characterization of Australian icons (wallaby, Tasmanian devil and platypus), more research on these, and other Australian animals, will further highlight the importance of Australian fauna and impact positively on our scientific profile.Read moreRead less
Origin and evolution of genes on the human X chromosome. Two groups of functionally related genes are found on the human X chromosome in disproportionately high numbers. I will test whether an uneven distribution of genes is common in mammalian genomes, or whether the human X is special. I will test hypotheses of how the gene groups arose on the human X by comparing their location and expression patterns in other mammals, and other vertebrates. It will then be clear whether the ancestral autosom ....Origin and evolution of genes on the human X chromosome. Two groups of functionally related genes are found on the human X chromosome in disproportionately high numbers. I will test whether an uneven distribution of genes is common in mammalian genomes, or whether the human X is special. I will test hypotheses of how the gene groups arose on the human X by comparing their location and expression patterns in other mammals, and other vertebrates. It will then be clear whether the ancestral autosome was ?chosen?, whether it ?selfishly? accumulated these genes, or whether the function of genes changed in response to selective pressures.Read moreRead less
Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing seque ....Small is beautiful: Did gene-rich regions of mammal chromosomes evolve from microchromosomes? Most birds and reptile genomes feature many tiny microchromosomes. These are not junk, as previously thought, but contain most of the genes. Mammals lack microchromosomes, but contain gene-rich regions with similar attributes. We suggest that microchromosomes originated by genome duplication, and evolved into the gene-rich regions of mammalian chromosomes. We will test this hypothesis by comparing sequences and genes in microchromosomes of birds, reptiles and monotremes. This will clarify the origin and evolution of the ?microgenome?, establish its suitability as a model for vertebrate genome organisation, and demonstrate whether microchromosomes are the ancestors of the gene-rich regions of mammalian chromosomes.Read moreRead less
Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a mo ....Origin and Evolution of Mammalian Dosage Compensation. The primary benefits are contribution to Australia's knowledge base and raising the profile of functional comparative genomics in Australia, with the research priority of 'Frontier Technologies for Building and Transforming Australian Industries' and priority goals in 'Breakthrough Science and Frontier Technologies'. This project addresses fundamental questions about the evolution of mammalian X-chromosome inactivation, of importance as a model for epigenetic change, and sex chromosomes, which has engaged some of the greatest genetic minds over nearly a century. Therefore my results will attract wide international interest and impact positively on Australia's scientific profile, and further highlight the importance of Australian mammals.Read moreRead less
Epigenesis and sociality: Unraveling the link between nutrition and the genome - how do genes and environment interact to produce phenotypes? This project has the capacity to transform our understanding of how genes and environment interact to produce whole-organism phenotypes. It will provide novel data on how an entire genome responds to nutrition and how external factors can enforce a differential expression of a common heritable genetic program. The national and community benefits of the pro ....Epigenesis and sociality: Unraveling the link between nutrition and the genome - how do genes and environment interact to produce phenotypes? This project has the capacity to transform our understanding of how genes and environment interact to produce whole-organism phenotypes. It will provide novel data on how an entire genome responds to nutrition and how external factors can enforce a differential expression of a common heritable genetic program. The national and community benefits of the project will be to maintain Australian leadership in epigenetics and advanced genetics of complex self-organizing systems. The findings of this project have the potential to be applicable to explaining regulatory networks underlying diet induced changes in human gene expression.Read moreRead less
Molecular characterization of marsupial genome organization, function and evolution. I will initiate a coherent investigation of the genome of an Australian marsupial (the tammar wallaby), exploiting new resources, new techniques and the hugely increased capacity for large-scale investigations of genomes at the molecular level. I will isolate and characterize large-insert (BAC) clones of the gene-rich region of the Y chromosome, ancient, added and controlling regions of the X chromosome, and aut ....Molecular characterization of marsupial genome organization, function and evolution. I will initiate a coherent investigation of the genome of an Australian marsupial (the tammar wallaby), exploiting new resources, new techniques and the hugely increased capacity for large-scale investigations of genomes at the molecular level. I will isolate and characterize large-insert (BAC) clones of the gene-rich region of the Y chromosome, ancient, added and controlling regions of the X chromosome, and autosomal imprinted regions. Comparisons with the homologous regions of the human and mouse genomes will identify and characterize new mammalian genes and control signals, untangle complex regulatory systems, and discover how mammalian genes, and the mammalian genome, evolved.Read moreRead less
Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersectio ....Authenticity: Globalisation and Indigenous Culture. Who speaks for the Fourth World? Why is there an obsession with 'authenticity' whenever Indigenous people are being discussed? This study explores those questions by examining a combination of sources, ranging from international museum collections to the advertising campaigns of multinational companies; from literature to the cultural festivals of the Olympic Games. The research is original, comparative, empirical. It explores the intersections between postcolonial and cultural studies to speak -- not for Indigenous peoples -- but to the non-Indigenous representation of First Nations. Why? Because this provides key insights into the future of race relations in western democracies.Read moreRead less
Wild Man from Borneo: species, race, representation. This project addresses the representation of species boundaries in Western accounts of the orangutan in the 19th and 20th centuries. Darwinian theory raised the possibility that animals could ?evolve?. Orangutans seemed ?closest? to humans and therefore raised key questions about the border between humans and animals. These questions were addressed in a vast range of scientific, popular, imaginative and juvenile literature. Even when ecolo ....Wild Man from Borneo: species, race, representation. This project addresses the representation of species boundaries in Western accounts of the orangutan in the 19th and 20th centuries. Darwinian theory raised the possibility that animals could ?evolve?. Orangutans seemed ?closest? to humans and therefore raised key questions about the border between humans and animals. These questions were addressed in a vast range of scientific, popular, imaginative and juvenile literature. Even when ecological models of the environment shifted attention from evolutionary potential to ecological role, orangutans retained a special status as ?sentinel? species. This project will produce a monograph examining the construction, maintenance and erosion of ideas of species boundaries.Read moreRead less
Mobile Indonesians: social differentiation and digital literacies in the twenty first century. This is the first dedicated study of the social implications of mobile telephony's recent and rapid popularisation throughout the country. This project will study metropolitan, urban and rural users to understand how mobile phones create the new and unexpected social networks which will shape tomorrow's Indonesians.