Engineering biomaterials that actively promote blood vessel growth. This project aims to improve understanding of the effect of biomaterials on vascular growth & to develop new biomimetic materials using natural polymers silk & gelatin. It expects to generate new knowledge in biomaterials, matrix biology & advanced material processing. Expected outcomes include new knowledge & technological advances in biomaterial-driven vascular growth, porous material manufacture, & proteoglycan-mediated grow ....Engineering biomaterials that actively promote blood vessel growth. This project aims to improve understanding of the effect of biomaterials on vascular growth & to develop new biomimetic materials using natural polymers silk & gelatin. It expects to generate new knowledge in biomaterials, matrix biology & advanced material processing. Expected outcomes include new knowledge & technological advances in biomaterial-driven vascular growth, porous material manufacture, & proteoglycan-mediated growth factor signalling, as well as cross-disciplinary, international collaboration & research training. This should provide significant benefit to Australia’s scholarly output & reputation & long term benefits to biomedical, veterinary, cosmetic, & food industries through new materials & processing technologies. Read moreRead less
Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advan ....Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advances in materials and surface engineering and the Partner Organisation’s (Codex Research) new bioreactor platform. It will offer a solution for modelling of native vessel processes in vitro that would be more appropriate for pre-clinical drug and device development, and in the long-term, tissue replacement.Read moreRead less